A review of issues of nomenclature and taxonomy of <i>Hypericum perforatum</i> L. and Kew's Medicinal Plant Names Services

Dauncey, Elizabeth A.; Irving, Jason; Allkin, Robert

doi:10.1111/jphp.12831

Cited by 26 publications

(13 citation statements)

References 22 publications

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“…For example, H. perforatum L. is confirmed as the accepted name and attribution with the highest quality rating for confidence in the taxonomy, and three illegitimate scientific synonyms are noted. Issues around the nomenclature of H. perforatum subspecies are discussed in a separate MPNS publication [ 33 ]. There are 142 nonscientific names listed with the corresponding medicinal plant reference sources.…”

Section: Resultsmentioning

confidence: 99%

“…The large number of H. perforatum ITS sequences also allowed consistent sites of intraspecific variation to be identified ( Figure S1 ) [ 12 ]. Four subspecies of H. perforatum are recognized by Robson ( perforatum , chinense , veronense and songaricum ) [ 29 ] but are rarely recorded in the published literature or database accessions [ 33 ]. Molecular phylogenetic studies have characterized two distinct gene pools in European H. perforatum populations, though their relationship to the subspecies is not clear [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

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Applied Barcoding: The Practicalities of DNA Testing for Herbals

Howard

Lockie-Williams

Slater

2020

Plants

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DNA barcoding is a widely accepted technique for the identification of plant materials, and its application to the authentication of commercial medicinal plants has attracted significant attention. The incorporation of DNA-based technologies into the quality testing protocols of international pharmacopoeias represents a step-change in status, requiring the establishment of standardized, reliable and reproducible methods. The process by which this can be achieved for any herbal medicine is described, using Hypericum perforatum L. (St John’s Wort) and potential adulterant Hypericum species as a case study. A range of practical issues are considered including quality control of DNA sequences from public repositories and the construction of individual curated databases, choice of DNA barcode region(s) and the identification of informative polymorphic nucleotide sequences. A decision tree informs the structure of the manuscript and provides a template to guide the development of future DNA barcode tests for herbals.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Applied Barcoding: The Practicalities of DNA Testing for Herbals

Howard

Lockie-Williams

Slater

2020

Plants

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“…In general, it is a licensed drug in many European countries and in the United Kingdom it is registered under the THR scheme. While considerable effort has gone into understanding the chemistry and pharmacology of commercially used materials, little attention has been paid to the biological and chemical complexity of the starting material and specifically to the diversity within the taxon H. perforatum (Dauncey et al, 2017). HP could be considered as an umbrella term for different Hypericum taxa united by the use as herbal medicines esp.…”

Section: Introductionmentioning

confidence: 99%

“…Robson (2002) proposed the distinction of four subspecies, based on minor morphological traits and with a well-defined geographical distribution of two of these subspecies, while the two Central/Western subspecies overlap through a large range of their territories (Dauncey et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

St. John’s Wort (Hypericum perforatum) Products – How Variable Is the Primary Material?

Scotti¹,

Löbel²,

Booker

et al. 2019

Front. Plant Sci.

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Background: Saint John’s wort (Hypericum perforatum L., HP) is commonly registered in Europe under the THR scheme (Traditional Herbal Registration) or licensed as a medicine. Nonetheless unregulated medical products and food supplements are accessible through the internet which are often of poor quality. The species’ natural distribution stretches through large regions of Europe to China and four subspecies have been distinguished. When compared to the European Pharmacopoeia reference, the presence of additional compounds was linked to so-called Chinese HP.Aim: In order to obtain an integrated picture of the entire chemoprofile, the chemical composition of HP materia prima was studied using a combination of techniques well-established in the relevant industries. The impact of phytogeographic factors on the materia prima can shed light on whether the variability of the final products is strongly influenced by these factors of whether they relate to poor processing, adulteration, or other factors linked to the processing of the material.Methods: Eighty-six Hypericum samples (77 H. perforatum) were collected from 14 countries. Most were authenticated and harvested in the wild; others came as roughly ground material from commercial cultivations, markets and pharmacies. The samples were analyzed using HPTLC and 1H-NMR-based principal component analysis (PCA).Results and Discussion: Limited chemical variability was found. Nonetheless, the typical fingerprint of Chinese HP was observed in each specimen from China. Additional compounds were also detected in some samples collected in Spain. Rutin is not necessarily present in the crude material. The variability previously found in the marketed products can be ascribed only partially to the geographical origin of harvested material, but mainly to the plant part harvested, closely related to harvesting techniques, processing and probably time of harvest.Conclusion: HP can be sourced in a consistent composition (and thus quality) from different geographical sources. However, chemical variability needs to be accounted for when evaluating what is considered authentic good material. Therefore, the processing and good practice are all stages of primary importance, calling for a better (self-)regulation and quality assurance along the value chain of an herbal medical product or botanical.

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“…However, the importance of this is often overlooked, and the use of imprecise or incorrect plant names is ubiquitous in published literature. The complexities of searching the scientific literature for publications on botanical species, and the importance of botanical nomenclature and taxonomy in this endeavour are tackled by Dauncey et al using H. perforatum as an example. Their position paper illustrates the necessity for researchers to be familiar with the full range of names used to describe a particular species to ensure relevant information is not missed; likewise, to achieve maximum impact when communicating their own research, authors should refer to the current accepted scientific name, scientific synonyms and non‐scientific names as far as possible.…”

mentioning

confidence: 99%

St John's wort (Hypericum perforatum L.): botanical, chemical, pharmacological and clinical advances

Barnes

Arnason

Roufogalis

2019

Journal of Pharmacy and Pharmacology

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A review of issues of nomenclature and taxonomy of Hypericum perforatum L. and Kew's Medicinal Plant Names Services

Abstract: Objectives To review which names are used to refer to Hypericum perforatum L. in health regulation and medicinal plant references, and the potential for ambiguity or imprecision.

Cited by 26 publications

References 22 publications

Applied Barcoding: The Practicalities of DNA Testing for Herbals

Applied Barcoding: The Practicalities of DNA Testing for Herbals

St. John’s Wort (Hypericum perforatum) Products – How Variable Is the Primary Material?

St John's wort (Hypericum perforatum L.): botanical, chemical, pharmacological and clinical advances

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