A Review of Korean Medicine Treatment for Postherpetic Neuralgia

Kim, Min Ju; Ji, Hyun; Lee, Young Rok; Kim, Beom Seok; Sung, Kyung Jeh; Choi, Hyeon Kyu; Lee, Ye Ji; Jeon, Ju Hyun; Kim, Young Il

doi:10.13045/jar.2021.00171

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…[7] Traditional medicines, such as acupuncture, moxibustion, and herbal medicine, can be considered potential treatments for PHN. According to a review of traditional medicine for PHN, [12] acupuncture and herbal medicine are most commonly used clinically to relieve pain and improve comorbidities. Although many systematic reviews [13][14][15] have shown that acupuncture is effective for patients with PHN, there are few reviews on the effectiveness of herbal medicine for patients with PHN.…”

Section: This Study Was Supported By the Korea Institute Of Oriental ...mentioning

confidence: 99%

Oral herbal medicine for treatment of postherpetic neuralgia: A protocol for systematic review and meta-analysis

et al. 2022

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Background: Postherpetic neuralgia (PHN) is the most common complication of shingling. Herbal medicine for PHN is clinically used to improve chronic pain and other symptoms that reduce the quality of life (QoL), such as sleep disturbances and emotional problems. This study aims to describe methods for synthesizing evidence for the effectiveness and safety of herbal medicine for treating PHN. Methods: Randomized controlled trials using herbal medicine in patients with PHN will be included in this review. Electronic databases such as MEDLINE via PubMed, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, China National Knowledge Infrastructure, WanFang, KoreaMed, Research Information Service System, Korean Studies Information Service System, Database Periodical Information Academic, Oriental Medicine Advanced Searching Integrated System, and Korea Citation Index will be searched without language limitations from their inception to September 2022. Two authors will perform quality assessments independently using the Cochrane risk-of-bias tool. The primary outcome will be pain intensity, and the secondary outcomes will be global impression, anxiety, depression, sleep disturbance, QoL, and safety. All data from eligible studies will be synthesized for meta-analysis. Results: This study will be a systematic review and meta-analysis to evaluate the effectiveness and safety of oral herbal medicine for treatment of PHN. Conclusion: This study will provide evidence for herbal medicine as a potential treatment for PHN which is advantageous not only for patients but also for researchers and policymakers.

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Section: This Study Was Supported By the Korea Institute Of Oriental ...mentioning

confidence: 99%

Oral herbal medicine for treatment of postherpetic neuralgia: A protocol for systematic review and meta-analysis

et al. 2022

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“…Since chronic pain diseases are accompanied by various symptoms as well as the pain itself, in Korea, these treatments are mainly used clinically in the form of integrative Korean medicine treatment (KMT) by combining these treatments. Integrative KMT, especially, is frequently used in clinical practice to treat the complex symptoms of PHN [32]. Many clinical studies are confined to nociceptive pain, but there is still a lack of evidence regarding neuropathic pain [33,34].…”

Section: Introductionmentioning

confidence: 99%

Effect of Korean Medicine Treatment on Patients with Postherpetic Neuralgia: A Retrospective Chart Review

Jeon,

Lee,

Kim

et al. 2024

Healthcare

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Evidence regarding Korean medicine treatment (KMT) for neuropathic pain is lacking. We aimed to identify the effects of integrative KMT in patients with postherpetic neuralgia (PHN). We retrospectively analyzed the electronic medical records of patients with PHN who received KMT at Kyung Hee University Korean Medicine Hospital between August 2021 and July 2022. We evaluated the effects of KMT—comprising acupuncture, pharmacopuncture, herbal medicine, cupping, and moxibustion—on pain intensity using the numerical rating scale (NRS), Short-Form McGill Pain Questionnaire (SF-MPQ), Hospital Anxiety and Depression Scale–Anxiety (HADS-A), Hospital Anxiety and Depression Scale–Depression (HADS-D), Daily Sleep Interference Scale (DSIS), Fatigue Severity Scale (FSS), and EuroQol-5D. Among 53 patients with PHN, 13 were included. The NRS score for worst pain over 1 week decreased from 6.54 ± 0.64 at baseline to 3.85 ± 0.63 at 8 weeks (41% reduction, p < 0.01), while that for average pain over 1 week decreased from 4.93 ± 0.67 at baseline to 3.08 ± 0.46 at 8 weeks (37% reduction, p < 0.01). From baseline to 8 weeks, there were significant reductions in the SF-MPQ, HADS-A, FSS, and EuroQol-5D scores. No adverse events were reported after KMT. Therefore, KMT may be an effective treatment option for patients with PHN.

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“…2 Herbal medicine treatment has been used to treat a range of pain-related conditions, and several reviews have demonstrated that herbal medicine can be an effective treatment for patients with PHN. [5][6][7] Qua et al have found that herbal medicine groups significantly alleviated pain intensity compared to western medicine groups, 5 and Liang et al further have shown that herbal medicine as an add-on therapy to pharmacotherapy had a better effect in reducing pain intensity and depression symptom severity compared to pharmacotherapy alone. 6 Paeoniae Radix and Glycyrrhizae Radix, which are the main herbs of Sogeonjungtang (SGJT), have already been used as a sedative, pain reliever, and anti-spasmodic in East Asia through anticholinergic, prostaglandin-productioninhibiting, antioxidation, and anti-inflammation as Jakyakgamchotang (also known as Shakuyakukanzo-to, Shaoyaogancao-tang).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of SIKD1977 in Combination with Standard Treatment for Postherpetic Neuralgia: Study Protocol for a Double Blind, Placebo-Controlled, Randomized, Multicenter, Phase 2 Clinical Trial

Jo¹,

Kim²,

Sung³

et al. 2023

JPR

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Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster, associated with poor quality of life and increased patient and healthcare resource expenditure. This randomized controlled trial aims to evaluate the efficacy and safety of SIKD1977 (Sogeonjungtang) in combination with standard treatment and estimate an effective dose for treating PHN. Patients and Methods: This is a protocol for a randomized, placebo-controlled, double-blind, multicenter trial. A total of 90 eligible participants with PHN will be recruited from three hospitals and randomly allocated to high-dose group, low-dose group, or placebo group in a 1:1:1 ratio. The trial will involve a 6-week oral administration of SIKD1977/placebo, and a 1-week follow-up period. The primary outcome will be the weekly average change in average daily pain score (ADPS) from baseline to the end of treatment. The secondary outcomes will include the weekly average changes in ADPS from baseline to week 2, 4, and 7, differences in Short-Form McGill Pain Questionnaire, Visual analogue scale, 5-level EuroQol-5 dimensions, Patient Global Impression of Change, and consumption of rescue drugs. All adverse events will be assessed during the trial. Conclusion: This study will provide evidence for the efficacy and safety of SIKD1977, and an effective dose for PHN. Trial Registration: This protocol has been registered in the Clinical Research Information Service with the identification code KCT0007939.

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A Review of Korean Medicine Treatment for Postherpetic Neuralgia

Cited by 4 publications

References 23 publications

Oral herbal medicine for treatment of postherpetic neuralgia: A protocol for systematic review and meta-analysis

Oral herbal medicine for treatment of postherpetic neuralgia: A protocol for systematic review and meta-analysis

Effect of Korean Medicine Treatment on Patients with Postherpetic Neuralgia: A Retrospective Chart Review

Efficacy and Safety of SIKD1977 in Combination with Standard Treatment for Postherpetic Neuralgia: Study Protocol for a Double Blind, Placebo-Controlled, Randomized, Multicenter, Phase 2 Clinical Trial

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