A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

Abrahamsen, Bo; Brask-Lindemann, D.; Rubin, Katrine Hass; Schwarz, Peter

doi:10.1038/bonekey.2014.69

Cited by 53 publications

(44 citation statements)

References 86 publications

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“…Similar results have previously been shown in women [10,11,12,13,14]. Increase in age is a potential non-modifiable risk factor for osteopenia and osteoporosis [1,4,5,10]. This was evident among both the premenopausal and postmenopausal women included in our study.…”

Section: Discussionsupporting

confidence: 77%

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Coffee Consumption Might Reduce the Risk of Osteopenia/Osteoporosis in Premenopausal Taiwanese Women

Chang¹,

Hsieh²,

Lin³

et al. 2017

JFNR

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The health impact of osteoporosis on individuals and the population at large is huge and its effect on national economies is negative. The aim of this study was to investigate the association between coffee consumption and osteopenia/osteoporosis in premenopausal and postmenopausal women in Taiwan. Data of 2929 women who completed a questionnaire about their weekly coffee consumption and bone health were retrieved from the Li-Shin Hospital (2006)(2007)(2008)(2009)(2010)(2011). Coffee consumption was classified into 0, 1-4 and 5-7 cups per week (1 cup was equivalent to 400 mL). Osteoporosis and osteopenia were defined using bone mineral densities measured by quantitative ultrasound (QUS). Multiple logistic regression was used to determine the association between coffee drinking and osteopenia/osteoporosis. After exclusions were made, a total of 2533 participants were included in the final analysis. Adjusted confounders included age, hepatitis B surface antigen (HBsAg), anti-Hepatitis C virus (HCV), waist-hip ratio (WHR), body mass index (BMI), smoking, alcohol, tea, exercise, vegetarian diet, supplements, yogurt, education, and blood type. There were 1336 premenopausal and 1593 postmenopausal women at baseline. Among the premenopausal women, an increase in the weekly coffee consumption significantly decreased the odds for osteoporosis (P-trend = 0.0179). The consumption of 1-4 and 5-7 cups of coffee per week significantly reduced the risk of osteoporosis/osteopenia (OR = 0.677; 95% C.I. = 0.469-0.978) and (OR = 0.607; 95% C.I. = 0.400-0.923), respectively. Among postmenopausal women, however, there was no significant relationship between weekly coffee consumption and osteoporosis/osteopenia. It was concluded that coffee drinking might likely minimize the risk of osteoporosis/osteopenia in premenopausal Taiwanese women.

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Section: Discussionsupporting

confidence: 77%

“…Osteopenia and osteoporosis are associated with several modifiable/non-modifiable risk factors [1,2]. Generally, both conditions are more common in the elderly [3,4,5,6], especially in females [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Coffee Consumption Might Reduce the Risk of Osteopenia/Osteoporosis in Premenopausal Taiwanese Women

Chang¹,

Hsieh²,

Lin³

et al. 2017

JFNR

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show abstract

“…Drugs being developed or used for treating osteoporosis include estrogen replacement therapy, calcitonin, selective estrogen receptor modulators, and diphosphate. Although these drugs prevent bone resorption, their effects on bone formation are extremely small (Abrahamsen et al, 2014;Bandeira et al, 2014;Chen and Kubo, 2014;Kulak et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Intestinal Absorption and Metabolism of Epimedium Flavonoids in Osteoporosis Rats

et al. 2015

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Herba Epimdii is a traditional Chinese medicine used to treat osteoporosis. Its main pharmacological ingredients are flavonoids. In previous studies conducted in healthy animals, we showed that epimedium flavonoids could be hydrolyzed into secondary glycosides or aglycon by intestinal flora or enzymes, thereby enhancing their absorption and antiosteoporosis activity. To study the medicine in the pathologic state, epimedium flavonoids were incubated with intestinal mucosa and feces in vitro and intestinal perfusion in situ to explore the differences in absorption and metabolism between sham and osteoporosis rats. For osteoporosis rats, the hydrolysis rates of icariin, epimedin A, epimedin B, and epimedin C incubated with intestinal flora for 1 hour were reduced by 0.19, 0.26, 0.19, and 0.14, respectively, compared with that in sham rats. Hydrolysis rates were reduced by 0.21, 0.24, 0.08, and 0.31 for icariin, epimedin A, epimedin B, and epimedin C incubated with duodenal enzymes for 1 hour and by 0.13, 0.09, 0.07, and 0.47 for icariin, epimedin A, epimedin B, and epimedin C incubated with jejunum enzymes, respectively, compared with the sham group. In addition, the apparent permeability coefficient and elimination percentage of the four epimedium flavonoids in the duodenum, jejunum, ileum, and colon decreased by 29%-44%, 32%-50%, 40%-56%, and 27%-53% compared with that in sham rats, respectively. The main metabolites of the four epimedium flavonoids were the same for the two groups after intestinal perfusion, or flora and enzyme incubation. In conclusion, the amount and activity of intestinal flora and enzymes changed in ovariectomized rats, which affected the intestinal absorption and hydrolysis of epimedium flavonoids whose structures contain 7-glucose.

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“…Any potentially modifiable risk factor should be addressed where at all possible. It might be remarked upon, however, that although most clinicians would consider this good practice, and would certainly seem sensible, we have little in the way of trial evidence to confirm our practice [6]. For example, exercise intervention programs have on occasion increased fracture rates through an increased fall rate [7].…”

Section: Treatment Options Currently Available In the Ukmentioning

confidence: 95%

What is needed to advance the treatment of osteoporosis in the UK?

Dulay¹,

Dennison²

2015

International Journal of Clinical Rheumatology

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Osteoporosis is a condition associated with a very significant personal and public health burden. Worldwide, osteoporotic fractures account for 0.83% of the global burden of noncommunicable disease. Despite recent huge advances, adherence to osteoporosis therapy is often poor. There has been a recent growing awareness of rare, but potentially serious, side effects that appear more common in patients who taken therapy for several years. This perspective considers the very significant advances we have made in management of this common condition in recent years, and more particularly highlights the areas where we remain uncertain about how best to advise our patients -and how to ensure that those individuals at highest risk are identified and treated.

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A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

Cited by 53 publications

References 86 publications

Coffee Consumption Might Reduce the Risk of Osteopenia/Osteoporosis in Premenopausal Taiwanese Women

Coffee Consumption Might Reduce the Risk of Osteopenia/Osteoporosis in Premenopausal Taiwanese Women

Intestinal Absorption and Metabolism of Epimedium Flavonoids in Osteoporosis Rats

What is needed to advance the treatment of osteoporosis in the UK?

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