A review of low-intensity focused ultrasound pulsation

Bystritsky, Alexander; Korb, Alex; Douglas, Pamela K.; Cohen, Mark S.; Melega, William P.; Mulgaonkar, Amit P.; DeSalles, Antonio; Min, Byoung-Kyong; Yoo, Seung Schik

doi:10.1016/j.brs.2011.03.007

Cited by 350 publications

(271 citation statements)

References 91 publications

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“…Although optogenetics or implanted electrodes would be ideal for this task, there are few situations in which these can be used in human subjects. A more practical method would be to use focused ultrasound [43] or high-definition transcranial direct current stimulation to deliver an appropriate signal to the brain. 18 Alternatively, it might be possible to use an inverse model to cancel out the sensory contingencies of a particular channel.…”

Section: Resultsmentioning

confidence: 99%

Conscious Sensation, Conscious Perception and Sensorimotor Theories of Consciousness

Gamez

2014

Studies in Applied Philosophy, Epistemology and Rational Ethics

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Section: Resultsmentioning

confidence: 99%

Conscious Sensation, Conscious Perception and Sensorimotor Theories of Consciousness

Gamez

2014

Studies in Applied Philosophy, Epistemology and Rational Ethics

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“…Magnetic stimulation technology achieves noninvasive possibilities, but there are limitations of parameter measurement imbalance and technical feasibility of focusing on the area of action. On the other hand, the magnetic field spatial resolution limits feasibility when it in the deep brain stimulation [18]. Ultrasound, as a safe, noninvasive, spatial resolution and noninvasive means, is increasingly recognized for disease diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ultrasound on Behavior and Dopamine Content in Striatum of Parkinson's Disease Model Mouse

Wang¹,

Li²,

Wu³

et al. 2017

Proceedings of the 2017 International Conference on Material Science, Energy and Environmental Engineering (MSEEE 2017)

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Abstract. In this research, we established a MPTP mouse model of PD, then ultrasound was used to stimulate the model to explore the effects of ultrasound on behavior and dopamine content in striatum. With the prolongation of ultrasonic stimulation time, the delay of observation time, the amount of DA in the striatum of the ultrasonic treatment group was increasing. Using ultrasound with a frequency of 1 MHz at an intensity of 0.3W/cm 2 over 15min for 1d, 5d or 10d respectively, in each group, there was a significant difference in the content of DA in the striatum compare to PD observation group at the same observation time(P<0.05). Especially, the DA content in the striatum of the mice treated with the ultrasound for 10 d was not statistically significant compared with the control group(P>0.05). Combined with the results of climbing test and open field test and general behavioral changes, the difference between ultrasound group and PD group reached a significant level (P<0.05). In summary, ultrasound can increase the DA content in the brain and improve the motor capacity of PD model. It suggests that ultrasound may be a safe and effective new method of PD treatment. IntroductionParkinson's disease (PD) is a common neurodegenerative disorder characterized by the reduce of the striatal DA level, which is related to the degeneration, death and deletion of dopaminergic neurons in the substantia nigra pars compacta (SNc), as well as the decrease of dopamine biosynthesis ability of the surviving neurons [1][2][3]. A series of clinical symptoms including resting tremor, rigidity, bradykinesia and postural instability will appear when DA content is lower than 70%. The gold standard for the treatment of PD is Levodopa therapy, which is aimed at increasing the availability of striatal dopamine and typically result in a brisk symptomatic improvement in most PD patients. Unfortunately, this response becomes less reliable and less predictable over time, medication related complications such as dyskinesia and "on-off" fluctuations develop in a majority of patients [4]. Because of the side effect of Levodopa therapy, researchers started to explore new therapies for PD.Ultrasound, as a new physical therapy, has been shown to be an effective neuronal activity regulator. William et al [5] experiments found that ultrasound on the cat's lateral geniculate body can inhibit the visual cortex evoked potential. Bauer et al [6] in the study results confirmed that after the end of ultrasound intervention in patients with tremor ease, six months after treatment and the Webster score was significantly improved. Wang et al found that GDNF levels were increased in the striatum of PD rats after lipid-coated GDNF microspheres administration following low frequency ultrasound stimulation (20kHz, 5min per day, daily for 4weeks). Moreover, GDNF microspheres reduced apomorphine-induced rotations, and increased striatal dopamine and nigral tyrosine hydroxylase (TH) levels in PD rats. In this research, we established a MPTP mouse model of PD, then u...

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“…While the exact mechanism of LIFUS is unknown, prior studies have suggested that lower power sonications can cause either inhibitory or excitatory effects which are reversible. 31 The threshold for thermal ablation is not met with lower intensity sonications. Tufail et al observed clinical motor contraction following stimulation of the motor cortex of mice, 32 while others have described reversible suppression of visual-evoked potentials using LIFUS.…”

Section: The Future Of Focused Ultrasound Low-intensity Focused Ultramentioning

confidence: 99%

The Use of Magnetic Resonance Imaging-guided Focused Ultrasound in Movement Disorders—A Review

Talman

Shah

2017

US Endocrinology

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T he use of surgical treatments for movement disorders has been well established for several decades, with a strong focus, in the past, on ablative lesioning procedures and, more recently, deep brain stimulation. Magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) is emerging as a newly recognized surgical technique for the treatment of various movement disorders. The most robust data, demonstrating safety and efficacy of MRgFUS, have been published in trials directed at treatment of essential tremor (ET); however, many trials are underway to define its role in other movement disorders, such as Parkinson's disease with preliminary results echoing those from studies in ET. The full potential for use of MRgFUS, both in the field of movement disorders and beyond, is only beginning to be explored. KeywordsEssential tremor, Parkinson's disease, tremor, thalamotomy, focused ultrasound

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A review of low-intensity focused ultrasound pulsation

Cited by 350 publications

References 91 publications

Conscious Sensation, Conscious Perception and Sensorimotor Theories of Consciousness

Conscious Sensation, Conscious Perception and Sensorimotor Theories of Consciousness

Effects of Ultrasound on Behavior and Dopamine Content in Striatum of Parkinson's Disease Model Mouse

The Use of Magnetic Resonance Imaging-guided Focused Ultrasound in Movement Disorders—A Review

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