In order to meet the increasing demand for crops under challenging climate conditions, efficient and sustainable cultivation strategies are becoming essential in agriculture. Targeted herbicide use reduces environmental pollution and effectively controls weeds as a major cause of yield reduction. The key requirement is a reliable weed detection system that is accessible to a wide range of end users. This research paper introduces a self-built, low-cost, multispectral camera system and evaluates it against the high-end MicaSense Altum system. Pixel-based weed and crop classification was performed on UAV datasets collected with both sensors in maize using a U-Net. The training and testing data were generated via an index-based thresholding approach followed by annotation. As a result, the F1-score for the weed class reached 82% on the Altum system and 76% on the low-cost system, with recall values of 75% and 68%, respectively. Misclassifications occurred on the low-cost system images for small weeds and overlaps, with minor oversegmentation. However, with a precision of 90%, the results show great potential for application in automated weed control. The proposed system thereby enables sustainable precision farming for the general public. In future research, its spectral properties, as well as its use on different crops with real-time on-board processing, should be further investigated.