A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors—implications for research on perinatal outcomes in the ECHO program

Padula, Amy; Monk, Catherine; Brennan, Patricia A.; Borders, Ann; Barrett, Emily S.; McEvoy, Cindy T.; Foss, Sophie; Desai, Preeya; Wurth, Renee; Salafia, Carolyn M.; Fichorova, Raina N.; Varshavsky, Julia; Kress, Amii M.; Woodruff, Tracey J.; Morello‐Frosch, Rachel

doi:10.1038/s41372-019-0510-y

Cited by 63 publications

(47 citation statements)

References 123 publications

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“…Similarly, levels of certain PFAS differ across socioeconomic status (SES) groups [ 24 , 25 ]. The cumulative effects and interactions of psychosocial stressors and environmental chemicals are beginning to be studied in more depth [ 26 ]. However, one of the challenges in assessing the extent to which certain demographic groups are more vulnerable to the effects of EDCs is the small sample size of many cohorts.…”

Section: Introductionmentioning

confidence: 99%

“…In response, the Environmental influences on Child Health Outcomes (ECHO) program was developed by the National Institutes of Health (NIH). ECHO combines existing longitudinal pregnancy and child cohorts [ 26 ]. In response to the ECHO initiative, two ongoing prospective birth cohorts, Chemicals in Our Bodies (CIOB) and Illinois Kids Development Study (IKIDS), integrated to form ECHO.CA.IL, a geographically, socio-economically, racially and ethnically diverse cohort.…”

Section: Introductionmentioning

confidence: 99%

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Associations of Maternal Stress, Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFAS), and Demographic Risk Factors with Birth Outcomes and Offspring Neurodevelopment: An Overview of the ECHO.CA.IL Prospective Birth Cohorts

Eick

Enright

Geiger

et al. 2021

IJERPH

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Background. Infants whose mothers experience greater psychosocial stress and environmental chemical exposures during pregnancy may face greater rates of preterm birth, lower birth weight, and impaired neurodevelopment. Methods. ECHO.CA.IL is composed of two cohorts, Chemicals in Our Bodies (CIOB; n = 822 pregnant women and n = 286 infants) and Illinois Kids Development Study (IKIDS; n = 565 mother-infant pairs), which recruit pregnant women from San Francisco, CA and Urbana-Champaign, IL, respectively. We examined associations between demographic characteristics and gestational age, birth weight z-scores, and cognition at 7.5 months across these two cohorts using linear models. We also examined differences in biomarkers of exposure to per- and polyfluoroalkyl substances (PFAS), measured in second-trimester serum, and psychosocial stressors by cohort and participant demographics. Results. To date, these cohorts have recruited over 1300 pregnant women combined. IKIDS has mothers who are majority white (80%), whereas CIOB mothers are racially and ethnically diverse (38% white, 34% Hispanic, 17% Asian/Pacific Islander). Compared to CIOB, median levels of PFOS, a specific PFAS congener, are higher in IKIDS (2.45 ng/mL versus 1.94 ng/mL), while psychosocial stressors are higher among CIOB. Across both cohorts, women who were non-white and single had lower birth weight z-scores relative to white women and married women, respectively. Demographic characteristics are not associated with cognitive outcomes at 7.5 months. Conclusions. This profile of the ECHO.CA.IL cohort found that mothers and their infants who vary in terms of socioeconomic status, race/ethnicity, and geographic location are similar in many of our measures of exposures and cognitive outcomes. Similar to past work, we found that non-white and single women had lower birth weight infants than white and married women. We also found differences in levels of PFOS and psychosocial stressors based on geographic location.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of Maternal Stress, Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFAS), and Demographic Risk Factors with Birth Outcomes and Offspring Neurodevelopment: An Overview of the ECHO.CA.IL Prospective Birth Cohorts

Eick

Enright

Geiger

et al. 2021

IJERPH

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“…Organic UV filters are emerging contaminants present ubiquitously in the environment. Human exposure to these EDCs is a global concern due to their adverse effects on human hormone systems [ 75 , 76 ] and an important target for thyroid disruption [ 76 ] namely in vulnerable populations such as pregnant women [ 1 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the main endocrine disruptive activities of EDCs the modulation of thyroid activity is highlighted [ 1 ], with studies reporting that EDCs exposure may be correlated with the incidence of thyroid diseases [ 3 , 4 ]. This is particularly relevant on populations more susceptible to endocrine disruption, such as pregnant women and developing fetuses [ 1 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

UV-B Filter Octylmethoxycinnamate Alters the Vascular Contractility Patterns in Pregnant Women with Hypothyroidism

2021

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Increasing evidence relating the exposure and/or bioaccumulation of endocrine-disrupting compounds (EDCs) with cardiovascular system are arising. Octylmethoxycinnamate (OMC) is the most widely used UV-B filter and as EDC interacts with TH receptors. However, their effects on thyroid diseases during pregnancy remain unknown. The purpose of this work was to assess the short- and long-term effects of OMC on arterial tonus of pregnant women with hypothyroidism. To elucidate this, human umbilical artery (HUA) rings without endothelium were used to explore the vascular effects of OMC by arterial and cellular experiments. The binding energy and the modes of interaction of the OMC into the active center of the TSHR and THRα were analyzed by molecular docking studies. Our results indicated that OMC altered the contractility patterns of HUA contracted with serotonin, histamine and KCl, possibly due to an interference with serotonin and histamine receptors or an involvement of the Ca2+ channels. The molecular docking analysis show that OMC compete with T3 for the binding center of THRα. Taken together, these findings pointed out to alterations in HUA reactivity as result of OMC-exposure, which may be involved in the development and increased risk of cardiovascular diseases.

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“…They may also stimulate or suppress the endocrine system, causing the over- or under-production of hormones, thereby disturbing the human endocrine system. Consequently, even low doses of EDCs in a vulnerable period of someone’s life can cause PPD if they are subjected to repeated exposure [ 9 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Endocrine-Disrupting Chemicals in Breast Milk on Postpartum Depression in Korean Mothers

Kim

Shin

Lee

2021

IJERPH

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Previous human and animal studies have reported an association between endocrine-disrupting chemicals (EDCs) and anxiety/depression. This study aimed to determine how the concentrations of phthalate metabolites, bisphenol A, triclosan, and parabens in breast milk are associated with the risk of developing postpartum depression (PPD) in Korean mothers. We recruited 221 mothers who were receiving lactation coaching at breastfeeding clinics between July and September 2018. The breast milk samples were collected along with responses to the Edinburgh Postnatal Depression Scale. The multivariable logistic regression results revealed that the phthalate, bisphenol A, parabens, and triclosan levels in the breast milk were not significantly associated with the risk of PPD. This study was the first attempt to analyze the association between the levels of EDCs in breast milk and the risk of PPD. Considering that PPD is a condition that affects not only the women diagnosed with it, but also their children and families, the results of this study may have great relevance to populations in environmentally sensitive periods.

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A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors—implications for research on perinatal outcomes in the ECHO program

Cited by 63 publications

References 123 publications

Associations of Maternal Stress, Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFAS), and Demographic Risk Factors with Birth Outcomes and Offspring Neurodevelopment: An Overview of the ECHO.CA.IL Prospective Birth Cohorts

Associations of Maternal Stress, Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFAS), and Demographic Risk Factors with Birth Outcomes and Offspring Neurodevelopment: An Overview of the ECHO.CA.IL Prospective Birth Cohorts

UV-B Filter Octylmethoxycinnamate Alters the Vascular Contractility Patterns in Pregnant Women with Hypothyroidism

Impact of Endocrine-Disrupting Chemicals in Breast Milk on Postpartum Depression in Korean Mothers

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