A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity

Najafi, Nahid Mashkouri; Rezaee, Ramin; Hayes, A WallaceQuery; Karimi, Gholamreza

doi:10.1007/s10534-022-00482-6

Cited by 7 publications

(2 citation statements)

References 88 publications

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“…Chelating properties and the ability to enhance the activity of catalase, glutathione antioxidant system, and superoxide dismutase enzymes also contribute to their protective profile against As toxicity. Several isolated natural compounds present in medicinal plants have shown ameliorative effects against As toxicity in animal models and in vitro studies, among which the following have the greatest amount of experimental evidence in the context of neuroptotection (an extensive list can be found in Bjørklund et al, 2022 [275], and Najafi et al, 2023 [279]): Alpha and dihydrolipoic acid (α-LA and DHLA), curcumin, D-pinitol, hydroxytyrosol, ellagic acid, glycyrrhetinic acid, luteolin, lycopene, quercitin, taurine, thymoquinone, epigallocatechin-3-gallate, sulforophane, and α-tocopherol. The ameliorative efficacy of these compounds includes their ability to reduce inflammation and As levels in the brain tissue; modulate cell death mediated via apoptosis or autophagy; reduce lactate dehydrogenase levels and caspase 3 activity; induce SOD, CAT, γ-glutamylcysteine synthetase (γ-GCS), and GSH-peroxidase activity; boost GSH intracellular levels; reduce intracellular ROS and MDA levels; reduce mitochondrial dysfunction and restore ATP synthesis; prevent As-induced DNA fragmentation; block NF-κB pro-inflammatory signaling pathways; and activate the Nrf2-signaling pathway [280][281][282][283][284][285][286][287][288].…”

Section: Nutritional Interventions and Natural Compoundsmentioning

confidence: 99%

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Vázquez Cervantes,

González Esquivel,

Ramírez Ortega

et al. 2023

Cells

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Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air; however, its chronic exposure, even with low doses, represents a public health concern. For a long time, As was used as a pigment, pesticide, wood preservative, and for medical applications; its industrial use has recently decreased or has been discontinued due to its toxicity. Due to its versatile applications and distribution, there is a wide spectrum of human As exposure sources, mainly contaminated drinking water. The fact that As is present in drinking water implies chronic human exposure to this metalloid; it has become a worldwide health problem, since over 200 million people live where As levels exceed safe ranges. Many health problems have been associated with As chronic exposure including cancer, cardiovascular diseases, gastrointestinal disturbances, and brain dysfunctions. Because As can cross the blood–brain barrier (BBB), the brain represents a target organ where this metalloid can exert its long-term toxic effects. Many mechanisms of As neurotoxicity have been described: oxidative stress, inflammation, DNA damage, and mitochondrial dysfunction; all of them can converge, thus leading to impaired cellular functions, cell death, and in consequence, long-term detrimental effects. Here, we provide a current overview of As toxicity and integrated the global mechanisms involved in cognitive and behavioral impairment induced by As exposure show experimental strategies against its neurotoxicity.

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Section: Nutritional Interventions and Natural Compoundsmentioning

confidence: 99%

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Vázquez Cervantes,

González Esquivel,

Ramírez Ortega

et al. 2023

Cells

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“…The inorganic/trivalent form of arsenic is the most reactive and lethal to all living organisms. 3 In potable water, arsenic comes from different natural and anthropogenic sources e.g., pesticide application of arsenic in agriculture and use of arsenic in therapeutics and several industries e.g., glass manufacturing industries, wood preservative industries and in car batteries as a semi-conductor etc. 4 As reported by WHO the safe limit of arsenic in potable water is about 10 μg/L 5,6 According to a report, millions of people across the world are badly suffering from the noxious effects of arsenic by using polluted groundwater.…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Mir,

Yasmeen

et al. 2024

JRMC

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Objective: To find out the toxic effects of arsenic on the histology of the vagina and reproductive hormones of female Sprague Dawley rats. Methods: 60 female Sprague Dawley rats were divided into control group A and experimental group B with 30 rats in each group. The gross weight of all the rats was checked before and at the end of the experiment. After one week of acclimatization, the control group was administered 10ml of distilled water by oral gavage daily for 14 days and the experimental group was administered 4µg of sodium arsenite dissolved in 10ml of distilled water by oral gavage daily for 14 days. After being euthanized by chloroform inhalation on day 15, blood from each rat was drawn by a single intra-cardiac puncture and stored for biochemical analysis. After that, rats were sacrificed and the whole reproductive tract was removed and vaginal sections were prepared and stained with hematoxylin and eosin (H&E ). The histological parameters were analyzed by using Image J software. Whereas, biochemical parameters e.g. serum LH and FSH levels were analyzed by ELISA. Results: After exposure to a low dose of arsenic administered for a short period, the gross weight of rats, weight of reproductive tract, height of vaginal epithelium and serum FSH and LH values were significantly reduced in experimental animals as compared to control animals with p-value < 0.05. Conclusion: Low dose of arsenic given via contaminated drinking water for a short period is very toxic to the female reproductive tract which is evident by the histological changes in the vagina and deranged hormonal profile of female Sprague Dawley rats. Keywords: Arsenic, FSH, Free radicals, LH, Oxidative stress, Vagina.

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Alpha-lipoic acid, as an effective agent against toxic elements: a review

Vafaee,

Derakhshani,

Ghasemzadeh Rahbardar

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity

Cited by 7 publications

References 88 publications

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Alpha-lipoic acid, as an effective agent against toxic elements: a review

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