A Review of Medicinal Plants Traditionally used to Treat Male Sexual Dysfunctions – the Overlooked Potential of Acmella oleracea (L.) R.K. Jansen

Batista, Lecildo Lira; Nascimento, Lucas Corrêa do; Guimarães, Gabriel Francisconi; Pereira, Arlindo César Matias; Koga, Rosemary de Carvalho Rocha; Santos, Abrahão Victor Tavares de Lima Teixeira dos; Fernandes, Caio P.; Teixeira, Thiago Afonso; Hu, Y. C.; Hu, Xuebo; Carvalho, José Carlos Tavares

doi:10.5530/phrev.2021.15.1

Cited by 4 publications

(7 citation statements)

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“…Many alkaloids have pharmacological properties such as analgesics [22], hallucinogens [23], anesthetics [24], antidiabetic [25], and anticancer [18]. Some studies suggest that plants that produce harmine, harmaline, and tetrahydroharmine alkaloids may have nephroprotective biological activity; that is, they may protect the kidneys against damage [26].…”

Section: Secondary Metabolites and Nephroprotectivementioning

confidence: 99%

Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

Paes,

Koga,

Sales

et al. 2023

Molecules

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There are several Amazonian plant species with potential pharmacological validation for the treatment of acute kidney injury, a condition in which the kidneys are unable to adequately filter the blood, resulting in the accumulation of toxins and waste in the body. Scientific production on plant compounds capable of preventing or attenuating acute kidney injury—caused by several factors, including ischemia, toxins, and inflammation—has shown promising results in animal models of acute kidney injury and some preliminary studies in humans. Despite the popular use of Amazonian plant species for kidney disorders, further pharmacological studies are needed to identify active compounds and subsequently conduct more complex preclinical trials. This article is a brief review of phytocompounds with potential nephroprotective effects against acute kidney injury (AKI). The classes of Amazonian plant compounds with significant biological activity most evident in the consulted literature were alkaloids, flavonoids, tannins, steroids, and terpenoids. An expressive phytochemical and pharmacological relevance of the studied species was identified, although with insufficiently explored potential, mainly in the face of AKI, a clinical condition with high morbidity and mortality.

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Section: Secondary Metabolites and Nephroprotectivementioning

confidence: 99%

Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

Paes,

Koga,

Sales

et al. 2023

Molecules

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“…The use of jambù in folk medicine as an aphrodisiac has led research groups to study its sexually stimulating action [ 104 , 105 , 106 ]. Lira Batista et al analyzed the articles published up to 2021 in this regard, and they assumed that jambù works both by topical and oral administration, with a different mechanism of action [ 107 ]. Topically the aphrodisiac action probably depends on the tingling sensation on the glans caused by the inhibition of potassium channels and on the release of NO and prostacyclin.…”

Section: Biological Activitiesmentioning

confidence: 99%

A Review of the Chemistry and Biological Activities of Acmella oleracea (“jambù”, Asteraceae), with a View to the Development of Bioinsecticides and Acaricides

Ferrati

Baldassarri

Cappellacci

et al. 2022

Plants

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Human pathologies, environmental pollution, and resistance phenomena caused by the intensive use of chemical pesticides have shifted the attention of the agrochemical industries towards eco-friendly insecticides and acaricides. Acmella oleracea (L.) R. K. Jansen (jambù) is a plant native to South America, widely distributed and cultivated in many countries due to its numerous pharmacological properties. This review analyzes literature about the plant, its uses, and current knowledge regarding insecticidal and acaricidal activity. Acmella oleracea has proven to be a potential pesticide candidate against several key arthropod pest and vector species. This property is inherent to its essential oil and plant extract, which contain spilanthol, the main representative of N-alkylamides. As a result, there is a scientific basis for the industrial exploitation of jambù in the preparation of green insecticides. However, studies related to its toxicity towards non-target species and those aimed at formulating and developing marketable products are lacking.

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“…The therapeutic approaches available to treat this condition can be pharmacological or nonpharmacological. Nonpharmacological approaches include psychological counseling and behavioral techniques ( Batista et al, 2021 ), whereas pharmacological treatment includes topical agents and oral drugs. The main oral drugs used for PE are selective serotonin reuptake inhibitors, tramadol, Type 5 phosphodiesterase inhibitors, α-adrenergic blockers, and clomipramine ( Ciocanel et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…As alternatives, topical agents can be applied to reduce penile sensitivity. These include anesthetic agents and preservatives based on lidocaine and prilocaine, which act locally, with minimal systemic effects, or at most the slight possibility of allergic reactions ( Batista et al, 2021 ; Butcher et al, 2020 ; Gajjala & Khalidi, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…Given the potential side effects of the available pharmacological options, which can compromise treatment, there is a need for new pharmacological agents with minimal or no adverse effects. In this regard, a potential natural alternative is the plant Acmella oleracea (L.) R.K. Jansen, commonly referred to as jambu, which has long been used in traditional medicine as a potent sexual stimulant (Batista et al, 2021). With respect to the chemical composition and pharmacological properties of A. oleracea, spilanthol, the main phytochemical compound of this species (da Rocha et al, 2018;Ramsewak, 1999), has been demonstrated to be an effect alternative that can be used to enhance sexual activity.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Safety of a Pharmaceutical Formulation Containing an Extract of Acmella oleracea (L.) in Patients With Premature Ejaculation: A Pilot Study

et al. 2023

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Acmella oleracea (L.) R. K. Jansen (Asteraceae) is a plant species widely used in traditional Amazonian medicine to treat sexual dysfunction. The use of this plant has gained popularity because of its sensory properties, such as a tingling sensation. In this study on patients with premature ejaculation, we evaluated the clinical action of a nano-formulation containing an ethanolic extract of A. oleracea inflorescences. Major constituents in the extracts were identified based on gas chromatographic analysis. Participants used a spray preparation based on the A. oleracea extract for 12 weeks, during which they were instructed to apply the product 5 min prior to sexual intercourse. To assess therapeutic efficacy, participants were required to record the mean intravaginal latency time for ejaculation (IELT). During the period of spray treatment, the nano-formulation of A. oleracea increased participant IELT values ( M = 293 s) compared with the baseline values (193 s). This nano-formulation reported clinical action in patients with premature ejaculation. It is accordingly considered to have potential application as a therapeutic alternative with benefits for both patients and their partners. Given the small number of participants in this study, further multicenter studies involving a larger number of participants are needed to confirm these observations.

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A Review of Medicinal Plants Traditionally used to Treat Male Sexual Dysfunctions – the Overlooked Potential of Acmella oleracea (L.) R.K. Jansen

Cited by 4 publications

References 0 publications

Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects

A Review of the Chemistry and Biological Activities of Acmella oleracea (“jambù”, Asteraceae), with a View to the Development of Bioinsecticides and Acaricides

Clinical Safety of a Pharmaceutical Formulation Containing an Extract of Acmella oleracea (L.) in Patients With Premature Ejaculation: A Pilot Study

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