The future of large rivers is related to regional cooperation programs for the sustainable development of water and related resources in great river basins. The objective of this article is to present how roadmaps can be utilized for both building up sustainable development for the Nile River, and supporting the integration of national and regional development strategies in Egypt and other Nile basin countries. The strategic objective is to highlight a wide range of sustainable freshwater pathways for an inclusive, peaceful, and sustainable future for all. In particular, it focuses on generating innovative water solutions, actions, and practices that enhance water exploitation in large river basins, transboundary shared rivers, and other transboundary shared water resources. The roadmapping approach is adopted and developed widely in the science, technology, and innovation community. The paper concentrates on roadmapping as an important tool that promotes sound planning of sustainability of large rivers, and in particular, transboundary shared rivers. The roadmap analyzes the benefits of planning shared water cooperation that extends to ecological, economic, and political features, and also beyond the river for the benefit of all, and identifies at an early stage the actions needed to manage the associated technology and environmental risk. The roadmap includes the key water resources governance characteristics, geographical scope, climate change (CC), and its impact, member states, organizational structure, decision-making, data information sharing, monitoring, the role of multiple stakeholders, financing, legal basis, dispute resolution, and benefit sharing. Therefore, a roadmap for the Nile River can help raise productivity and support faster growth, if considered as a lighthouse for national development strategies. Roadmap for the Nile River proposes windows of opportunity and is a vital milestone for cooperation, peace, stability, joint investment, and prosperity. With possible benefits exceeding those derived from the river itself, a roadmap for the Nile River can catalyze strengthened cooperation and greater regional ecological, economic, social, and political integration. The paper concludes that the roadmap for the Nile River sustainability (NRS) is a promising model for assuring the sustainability of transboundary shared large rivers.