A Review of Methods for Plasma Paracetamol Estimation

Wiener, K

doi:10.1177/000456327801500141

Cited by 39 publications

(8 citation statements)

References 38 publications

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“…The results are therefore even more difficult to interpret than those from a method which gives complete hydrolysis. Wiener (1978) mentioned the problem of nonspecificity of some methods in his review and quoted the work of White (1976), which indicated that paracetamol may be overestimated.…”

Section: Resultsmentioning

confidence: 99%

“…Many methods have been described, and the subject has recently been reviewed by Wiener (1978). However, some methods which have become popular on the grounds of simplicity and speed are non-specific and give rise to serious errors since they also measure the inactive glucuronide and sulphate conjugates of paracetamol which are present in plasma in amounts which may greatly exceed the concentration of the unchanged drug (Prescott and Wright, 1973).…”

mentioning

confidence: 99%

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Inappropriate Methods for the Emergency Determination of Plasma Paracetamol

et al. 1979

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Methods for the estimation of plasma paracetamol which depend on acid hydrolysis to p-aminophenol without a prior extraction step also measure inactive metabolites which are present in high concentrations. The extent of the overestimate obtained with such methods was determined using 24 samples from patents after paracetamol overdosage. There was a positive error of between 40 and 700% compared with a high-performance liquid chromatography reference method which measured only unchanged paracetamol. These non-specific methods should not be used to determine the need for specific therapy in patients with paracetamol poisoning.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Inappropriate Methods for the Emergency Determination of Plasma Paracetamol

et al. 1979

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“…These methods were reviewed in 1978. 46 Only a brief resume of methods up to 1978 will be given here.…”

Section: Early Methodsmentioning

confidence: 99%

Analytical Reviews in Clinical Chemistry: Methods for the Estimation of Salicylate and Paracetamol in Serum, Plasma and Urine

Stewart

Watson

1987

Ann Clin Biochem

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“…Most of the samples were based on horse serum, and this can sometimes show different extraction characteristics from human samples (Wiener, 1978). However, laboratories using organic extraction methods displayed no obvious change in bias of results for the human samples that were distributed.…”

Section: Bmentioning

confidence: 99%

Experiences with a Regional Quality Control Scheme for Salicylate and Paracetamol over a Period of Two Years

Wiener

1980

Ann Clin Biochem

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SUMMARY The organisation of a regional quality control scheme for salicylate and paracetamol estimations in plasma is described. The results show considerable variation in both bias and precision between laboratories, with some overall improvement in performance during the second year of the scheme. No method can be singled out as producing better results than the others. The major factor seems to be the care with which the analyses are performed.

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A Review of Methods for Plasma Paracetamol Estimation

Cited by 39 publications

References 38 publications

Inappropriate Methods for the Emergency Determination of Plasma Paracetamol

Inappropriate Methods for the Emergency Determination of Plasma Paracetamol

Analytical Reviews in Clinical Chemistry: Methods for the Estimation of Salicylate and Paracetamol in Serum, Plasma and Urine

Experiences with a Regional Quality Control Scheme for Salicylate and Paracetamol over a Period of Two Years

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