A Review of Methods for Human Retinal Oximetry

Harris, Alon; Dinn, R.; Kagemann, Larry; Rechtman, Ehud

doi:10.3928/1542-8877-20030301-16

Cited by 134 publications

(156 citation statements)

References 41 publications

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“…To choose wavelengths for perfusion imaging of the eye a series of criteria was considered to introduce a new combination of wavelengths based on previous researches [5,12]. The criteria included safety, low absorbance, and independent scattering range.…”

Section: Beer-lambert Law For Haemoglobin Saturationmentioning

confidence: 99%

“…Tiedeman [2] and Beach [3] have improved this fundus photography technique using digital images choosing as one wavelength an isobestic wavelength. A scanning oximeter, employing three wavelengths, all in the green part of spectrum, of which two are isobestic, was developed in (1988) by Delori [4] and recently by other groups who improved this method using four wavelengths [5].…”

Section: Introductionmentioning

confidence: 99%

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The feasibility of oxygen perfusion imaging of the human retina using a new non-invasive near infrared imaging technique

Rasta

Manivannan

Sharp

2010

2010 17th Iranian Conference of Biomedical Engineering (ICBME)

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The feasibility of non-invasive imaging oxygen perfusion in the human retina was evaluated using a confocal scanning laser ophthalmoscope (cSLO) that adapted to use a new combination of two red (670 nm) and near infrared (810 nm) wavelengths simultaneously. Spectral analyses of the physiological status of retinal blood vessels give the ability to image perfusion in the human eye. This technique was evaluated using measurements made on an eye model, normal and diabetic retinopathy volunteers' eyes. The reproducibility of the measurements of reflected light from the eye was investigated. The measurements of light reflected from retinal vessels were determined and oxygen saturation of blood using spectral transmittance based on Beer-Lambert law was investigated. The relative oxygen levels of retinal blood vessels (artery and vein) were successfully determined using these two wavelengths. The technique showed promise in the determination of the relative oxygen saturation levels of the retina in amongst eye subjects.

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Section: Beer-lambert Law For Haemoglobin Saturationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The feasibility of oxygen perfusion imaging of the human retina using a new non-invasive near infrared imaging technique

Rasta

Manivannan

Sharp

2010

2010 17th Iranian Conference of Biomedical Engineering (ICBME)

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“…OD 586 is the optical density calculated using light at 586 nm, which is insensitive to oxygen saturation. It can be shown that there exists a linear relationship [5], [6], [8] 2 SatO = ODR + a b (5) where SatO 2 is the oxygen saturation of the hemoglobin in the blood.…”

Section: Physical Basis Of Optical Oximetrymentioning

confidence: 99%

“…Noninvasive measurement of oxygenation in the human retina and optic nerve has proved technically difficult but considerable progress has been made, particularly in recent years as digital technology, in computers and cameras, has evolved. Several methods have been tried in the past (for a review of retinal oximetry methods see [6]). …”

Section: Introductionmentioning

confidence: 99%

“…The principle of spectroscopic oximetry is well known [6] and the method has been developed into clinically useful instrumentation, such as the finger or earlobe oximeter, commonly used in anesthesiology and intensive care. Noninvasive measurement of oxygenation in the human retina and optic nerve has proved technically difficult but considerable progress has been made, particularly in recent years as digital technology, in computers and cameras, has evolved.…”

Section: Introductionmentioning

confidence: 99%

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Automatic Retinal Oximetry

Halldorsson¹,

Karlsson²,

Hardarson³

et al. 2007

AIP Conference Proceedings

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This paper presents a method for automating the evaluation of hemoglobin oxygen saturation in the retina. This method should prove useful for monitoring ischemic retinal diseases and the effect of treatment. In order to obtain saturation values automatically, spectral images must be registered in pairs, the vessels of the retina located and measurement points must be selected. The registration algorithm is based on a data driven approach that circumvents many of the problems that have plagued previous methods. The vessels are extracted using an algorithm based on morphological profiles and supervised classifiers. Measurement points on retinal arterioles and venules as well as reference points on the adjacent fundus are automatically selected. Oxygen saturation values along vessels are averaged to arrive at a more accurate estimate of the retinal vessel oxygen saturation. The system yields reproducible results as well as being sensitive to changes in oxygen saturation.

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Pulse Oximetry

Mendelson

2006

Wiley Encyclopedia of Biomedical Engineering

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Noninvasive monitoring of arterial oxygen saturation by pulse oximetry (SpO 2 ) was first adopted by anesthesiologists in the early 1980s in an effort to optimize patient safety. The goal of this technology was to identify as early as possible unrecognized episodes of hypoxemia (insufficient blood oxygenation) that often resulted in irreversible tissue damage and costly malpractice insurance claims. During the past decade, pulse oximetry has become a rapidly growing practice in many fields of clinical medicine, including subacute and long‐term care. Whether used as a safety guard or as a diagnostic tool, this new modality is widely acknowledged to be one of the most important technological advances in patient monitoring. The most important advantage of pulse oximetry is the capability to provide continuous, safe, and cost‐effective monitoring of blood oxygenation noninvasively at the patient bedside. It is particularly useful when a patient is unstable and subject to rapid or unpredictable oxygen desaturation. Pulse oximeters are easy to use, require no user calibration, and provide virtually maintenance‐free operation.

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A Review of Methods for Human Retinal Oximetry

Cited by 134 publications

References 41 publications

The feasibility of oxygen perfusion imaging of the human retina using a new non-invasive near infrared imaging technique

The feasibility of oxygen perfusion imaging of the human retina using a new non-invasive near infrared imaging technique

Automatic Retinal Oximetry

Pulse Oximetry

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