ObjectiveAssess the accuracy and efficiency of reduction provided by application of plates precontoured to 3‐dimensional (3D)‐printed femoral bone models using a custom fracture reduction system (FRS) or intramedullary pin (IMP) to facilitate femoral minimally invasive plate osteosynthesis (MIPO) in dogs.Study designExperimental cadaveric study.Sample populationSeven dog cadavers.MethodsVirtual 3D femoral models were created using computed tomographic images. Simulated, virtual mid‐diaphyseal femoral fractures were created and reduced. Reduced femoral models were 3D‐printed and a plate was contoured. Custom drill guides for plate screw placement were designed and 3D‐printed for the FRS. Mid‐diaphyseal simulated comminuted fractures were created in cadavers, and fractures were aligned using FRS or IMP and stabilized with the precontoured plates. Number of fluoroscopic images acquired per procedure and surgical duration were recorded. Computed tomographic scans were repeated to assess femoral length and alignment.ResultsCompared to the preoperative virtual plan, median change in femoral length and frontal, sagittal, and axial alignment was less than 3 mm, 2°, 3°, and 3° postoperatively, respectively, in both reduction groups. There was no difference in length or alignment between reduction groups (P > .05). During FRS, fewer fluoroscopic images were taken (P = .001), however, surgical duration was longer than IMP procedures (P = .011).ConclusionFemoral alignment was accurate when using plates precontoured to 3D printed models, regardless of reduction method.Clinical significanceAccurate plate contouring using anatomically accurate models may improve fracture reduction accuracy during MIPO applications. Custom surgical guides may reduce fluoroscopy use associated with MIPO.