A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants

Bitwell, Chibuye; Sen, Singh Indra; Chimuka, Luke; Kakoma, Maseka Kenneth

doi:10.1016/j.sciaf.2023.e01585

Cited by 129 publications

(109 citation statements)

References 110 publications

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“…Regarding the in-depth description of specific experimental designs, models, and details concerning the statistics involved in using these tools, interested readers are referred to the fundamental literature on the subject. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]27 The last part of the experimental design involves transforming the data obtained into information and their analysis. The model must be examined to determine if it shows good predictability; this means that it must adequately represent the response function in the experimental domain.…”

Section: Design Of Experimentsmentioning

confidence: 99%

Section: Design Of Experimentsmentioning

confidence: 99%

“…For this reason, many extraction techniques have been developed over the years, moving from conventional (i.e., maceration, percolation, and steam distillation) to the so-called unconventional methods (i.e., ultrasound-and microwave-assisted extraction, supercritical fluid extraction, and pressurized solvent extraction). [9][10][11] This review is focused on the Microwave-Assisted Solvent Extraction (MASE) methodology that exploits microwave radiation to heat the natural matrix. Microwaves are part of the electromagnetic spectrum, with frequencies from 300 MHz to 300 GHz corresponding to wavelengths ranging from 1 m to 1 mm.…”

Section: Introductionmentioning

confidence: 99%

“…, ultrasound- and microwave-assisted extraction, supercritical fluid extraction, and pressurized solvent extraction). 9–11…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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show abstract

Section: Design Of Experimentsmentioning

confidence: 99%

Section: Design Of Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…, ultrasound- and microwave-assisted extraction, supercritical fluid extraction, and pressurized solvent extraction). 9–11…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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show abstract

“…The choice of solvent (methanol, hexane, chloroform and so on) for extraction is based on the polarity of the phytochemicals of interest. The phytochemicals in the extracts are then separated by chromatography methods, such as column chromatography, thin‐layer chromatography and high‐performance liquid chromatography (HPLC; Abubakar & Haque, 2020; Altemimi et al, 2017; Bitwell et al, 2023). The isolated compounds are verified and characterized by various spectrometry methods such as UV‐Visible spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents

Wong,

Chow

2023

eFood

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The emergence and spread of pathogenic bacterial resistance to many antibiotics are on the rise globally, thereby posing a significant threat to public health. In response, scientists are actively investigating alternative therapeutic agents to combat antibiotic‐resistant microorganisms. This review focuses on the antimicrobial effects of commonly consumed spices, namely garlic, chilli peppers, turmeric, ginger and black pepper, which have shown promising results in previous research. The review highlights the key phytochemicals, including allicin, ajoene, capsaicin, dihydrocapsaicin, curcumin, 6‐gingerol, 6‐shogaol and piperine, responsible for their antimicrobial activities. Various pharmacological experiments to elucidate the action mechanism and metabolism of those bioactive compounds are described. Moreover, the synergistic effects of these phytochemicals with conventional antibiotics are discussed, emphasizing the potential to reduce the required antibiotic dosage for effective microbial inhibition. The review also addresses the gaps in current research, such as the variations in antimicrobial assay results across different research groups and the incomplete understanding of the synergistic mechanisms between antibiotics and phytochemicals. Finally, future research directions and opportunities are suggested to further explore the antimicrobial potential of these spice‐derived phytochemicals and bridge the existing knowledge gaps.

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UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

Cvetanović Kljakić,

Lončar,

Sinan

et al. 2024

Archiv der Pharmazie

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Lantana camara is widely known as a garden plant, but its use for various medicinal purposes is widespread in traditional medicine. In the frame of this study, L. camara was subjected to several different extraction techniques, including supercritical carbon dioxide extraction, accelerated solvent extraction (ASE), homogenizer‐assisted extraction, microwave‐assisted extraction, ultrasound‐assisted extraction, maceration, and Soxhlet extraction. The investigation encompasses the analysis of the chemical composition alongside assessments of biological activities, such as antioxidant and enzyme‐inhibition potential and cytotoxicity of the obtained extracts. The obtained results showed that the extract obtained by accelerated‐solvent extraction was the richest in the content of total phenols and of individual compounds. Of the 17 components identified in total, hispidulin was detected in the highest concentration (5.43–475.97 mg/kg). In the antioxidant assays, the extracts obtained by accelerated‐solvent and microwave extraction possessed the highest level of antioxidant and antiradical protection. All obtained extracts showed enzyme‐inhibitory action on amylase, glucosidase, tyrosinase, and cholinesterase, showing a high potential for application against diseases induced by excessive activity of these enzymes. Cytotoxic analysis was performed on normal and tumor cells, whereby the obtained IC50 values were in the range of 7.685–79.26 µg/mL, showing the high cytotoxicity of the obtained extracts. Using Z score analysis, ASE resulted in an optimal combination of tested quality characteristics of the L. camara extracts.

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A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants

Cited by 129 publications

References 110 publications

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents

UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

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