A review of modified DLC coatings for biological applications

Hauert, Roland

doi:10.1016/s0925-9635(03)00081-5

Cited by 614 publications

(337 citation statements)

References 53 publications

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“…Previous research has suggested early delamination based failures, and this indeed occurred in large numbers of implanted DLC coated hip joints in the past [7]. Testing by Lappalainen et al [39], and to a lesser extent Dowling et al [40] and Oñ ate et al [50] tested over 15 million, 6 million and 5 million cycles on joint simulators respectively(Lappalainen estimated 1 million cycles to be equivalent to 1 year in use).…”

Section: Potential Reasons For Differing Resultsmentioning

confidence: 99%

“…No cellular damage was recorded compared to the control samples [7], suggesting they would make good implant coatings.…”

Section: Dlc In the Bodymentioning

confidence: 85%

“…Titanium also reduces the residual stress by reducing the amount of sp 3 in the matrix, as well as improvements in the bonding between the substrate and the coating, further preventing delamination [20]. Titanium has also been shown to inhibit the growth of osteoclasts and other bone resorbing cells, improving the effectiveness of implants in situations where osseointegration is required [7].…”

Section: Dopantsmentioning

confidence: 99%

“…Reviews by Dearnaley and Arps [6], Hauert [7] and Cui and Li [8] all show promise in the use of a DLC coatings in in vitro testing. All propose further testing, with Dearnaley and Arps [6] suggesting the time for in vivo testing has arrived, whereas Hauert and Cui and Li suggest further in vitro testing is needed due to variable results.…”

Section: Introductionmentioning

confidence: 99%

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Diamond like carbon coatings for potential application in biological implants—a review

Love

Cook

Harvey

et al. 2013

Tribology International

237

118

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a b s t r a c tProduction of wear debris has been linked to the failure of numerous hip implants. With the current focus on increasing the implant longevity, thus wear and corrosion resistance is important. Hard coatings have the potential to reduce the wear and corrosion. Diamond like Carbon (DLC) coatings exhibit properties that could make them viable for implants. This paper critically reviews previously published research into usage of DLC coatings for implants. Overall DLCs seem to be an effective coating for implants but with the variance in results, further testing is required for clarification of use.

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Section: Potential Reasons For Differing Resultsmentioning

confidence: 99%

“…No cellular damage was recorded compared to the control samples [7], suggesting they would make good implant coatings.…”

Section: Dlc In the Bodymentioning

confidence: 85%

Section: Dopantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diamond like carbon coatings for potential application in biological implants—a review

Love

Cook

Harvey

et al. 2013

Tribology International

237

118

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show abstract

“…A majority of the investigations regarding biointeractions on carbon films have been carried out on diamond-like hydrogenated carbon (DLHC) and pyrolytic carbon, which already are in use in artificial heart valves [4]. Some bioadsorption studies on amorphous carbon (a-C) and diamond like carbon (DLC) films have been reported [5,6], but only a few adsorption tests of biomolecules on carbon nitrides (CN x ) have so far been presented [7][8][9]. A few studies on haemocompatibility of CN x -surfaces have also been published [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption on thin films of carbon and carbon nitride monitored with in situ ellipsometry

et al. 2011

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Amorphous carbon and amorphous, graphitic and fullerene-like carbon nitride thin filmswere deposited by reactive magnetron sputtering and optically characterized withspectroscopic ellipsometry. The films were exposed to human serum albumin and theadsorption was monitored in situ using dynamic ellipsometry. From the ellipsometric data theadsorbed amount of proteins was quantified in terms of surface mass density using de Feijter'smodel. The results indicated larger adsorption of proteins onto the amorphous films comparedto the films with a more ordered microstructure. Complementary studies with labeled HSAusing radioimmunoassay showed up to 6 times higher protein adsorption compared to theellipsometry measurement which partly might be explained by differences in surfaceroughness (from 0.3 to 13 nm) among the films. The elutability of adsorbed labeled HSAusing unlabeled HSA and sodium dodecyl sulphate was low compared to a silicon reference.In addition, the four types of films were incubated in blood plasma followed by antifibrinogen,anti-HMWK or anti-C3c revealing the materials response to complement andcontact activation. Three of the films indicated immunoactivity, whereas the amorphouscarbon showed less immunoactivity compared to a titanium reference. All films showedindications of a stronger ability to initiate the intrinsic pathway of coagulation, compared tothe reference. Finally, the surfaces bone bonding ability was investigated by examination oftheir ability to form calcium phosphate (CaP) crystals in a simulated body fluid, with a-CNxdepositing most CaP after 21 days of incubation.Original Publication:Torun Berlind, Pentti Tengvall, Lars Hultman and Hans Arwin, Protein adsorption on thin films of carbon and carbon nitride monitored with in situ ellipsometry, 2011, ACTA BIOMATERIALIA, (7), 3, 1369-1378.http://dx.doi.org/10.1016/j.actbio.2010.10.024Copyright: Elsevier Science B.V. Amsterdamhttp://www.elsevier.com

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Tribology of Diamond and Diamond‐Like Carbon Films

Erdemir¹,

Donnet²

2005

Wear – Materials, Mechanisms and Practice

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A review of modified DLC coatings for biological applications

Cited by 614 publications

References 53 publications

Diamond like carbon coatings for potential application in biological implants—a review

Diamond like carbon coatings for potential application in biological implants—a review

Protein adsorption on thin films of carbon and carbon nitride monitored with in situ ellipsometry

Tribology of Diamond and Diamond‐Like Carbon Films

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