A review of multifunctional nacre-mimetic materials based on bidirectional freeze casting

Gao, Weiwei; Wang, Mengning; Bai, Hao

doi:10.1016/j.jmbbm.2020.103820

Cited by 46 publications

(17 citation statements)

References 97 publications

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“…In the present study, oxidized dopamine (ODA) is introduced to crosslink HHK molecules as they are rich in amino‐ and sulfhydryl groups. In addition, directed ice‐templating method was used to achieve well‐defined microstructures by guiding material assembly 39‐44 . The resultant HHK‐ODA scaffolds had anisotropic microstructures (well‐aligned keratin layers with homogenous channels in between) and strain‐stiffening property with enhanced mechanical strength and extensibility (high strain at fracture).…”

Section: Introductionmentioning

confidence: 99%

Anisotropic hair keratin‐dopamine composite scaffolds exhibit strain‐stiffening properties

Zhao

Chua

Goh

et al. 2021

J Biomedical Materials Res

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Human hair keratin (HHK) has been successfully explored as raw materials for three‐dimensional scaffolds for soft tissue regeneration due to its excellent biocompatibility and bioactivity. However, none of the reported HHK based scaffolds is able to replicate the strain‐stiffening capacity of living tissues when responding to large deformations. In the present study, strain‐stiffening property was achieved in scaffolds fabricated from HHK via a synergistic effect of well‐defined, aligned microstructure and chemical crosslinking. Directed ice‐templating method was used to fabricate HHK‐based scaffolds with highly aligned (anisotropic) microstructure while oxidized dopamine (ODA) was used to crosslink covalently to HHKs. The resultant HHK‐ODA scaffolds exhibited strain‐stiffening behavior characterized by the increased gradient of the stress–strain curve after the yield point. Both ultimate tensile strength and the elongation at break were enhanced significantly (~700 kPa, ~170%) in comparison to that of HHK scaffolds lacking of aligned microstructure or ODA crosslinking. In vitro cell culture studies indicated that HHK‐ODA scaffolds successfully supported human dermal fibroblasts (HDFs) adhesion, spreading and proliferation. Moreover, anisotropic HHK‐ODA scaffolds guided cell growth in alignment with the defined microstructure as shown by the highly organized cytoskeletal networks and nuclei distribution. The findings suggest that HHK‐ODA scaffolds, with strain‐stiffening properties, biocompatibility and bioactivity, have the potential to be applied as biomimetic matrices for soft tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Anisotropic hair keratin‐dopamine composite scaffolds exhibit strain‐stiffening properties

Zhao

Chua

Goh

et al. 2021

J Biomedical Materials Res

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“…The smaller grain size of ceramic means the higher proportion of corresponding grain boundary. [ 57 ] The fracture energy of grain boundary is much smaller than that of grain interior. The path of crack propagation along the grain boundary becomes longer and circuitous.…”

Section: Resultsmentioning

confidence: 99%

Strong and Tough Alumina Ceramic from the Particle‐Stabilized Foam

et al. 2022

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Strength and toughness are two vital and contradictory properties, especially in alumina structural ceramics. This mutual exclusion limits the widespread application of advanced alumina ceramics in harsh environments. To deal with this issue, self‐toughening alumina bulk ceramics without any ductile phase and with a unique combination of excellent toughness and reliable strength by combining the foam ceramics with hot‐pressing sintering are prepared. Foam ceramics with honeycomb cellular structures are prepared by particle‐stabilized foaming. Then, the foam ceramics is directly hot pressed sintered, in which the cellular structure is fractured into fragments and completely dense under pressure. Equiaxed grains that constituting the fragments grow anisotropically into plate‐like grains with a large diameter–thickness ratio during hot‐pressing sintering. Plate‐like grains improve the material's fracture toughness by exerting a toughening mechanism similar to that of fibers. The self‐toughening alumina ceramics exhibit a unique combination of high flexural strength (874 ± 31 MPa) and high fracture toughness (6.2 ± 0.1 MPa m1/2). The Vickers hardness also can reach 21 GPa. Herein, a new strategy with relatively simple processing to fabricate high‐performance ceramics based on the widespread ceramic processing techniques are provided.

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“…Recently, ice frozen assembly has been revisited integrating with other materials' assembling methodologies such as, (electro) spraying, [117] electrospinning, [118,197,198] vacuum-filtration, [119] hydrothermal, [120] extrusion, [199] and tape casting [23,122,123] to construct more complex hierarchical macrostructures such as, beads/microspheres, [117,[200][201][202][203][204][205][206][207][208] fibers, [8,21,100,209] meshes, [210,211] films, [86,87,212,213] membranes, [94,126,214,215] and other complex morphologies. [216,217] Through the integration of various synthesis techniques with ice templating method, it is possible to control porous and macroscopic structure in a hierarchical manner.…”

Section: Control In the Orientation And Alignment Of Pores Under Exte...mentioning

confidence: 99%

A New Era of Integrative Ice Frozen Assembly into Multiscale Architecturing of Energy Materials

Yeon

Gupta

Bhattacharya

et al. 2022

Adv Funct Materials

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The ice templating assembly has been investigated to construct macroporous channels of functional nanomaterials with well‐defined homogeneous morphology. Recently, this templating method has been revisited integrating with other materials’ synthesis and processing methodologies (such as, spinning, spraying, filtration, hydrothermal, oxygenation, gelation, and 3D printing) for electrochemical energy conversion and storage applications. Herein, the recent progress on “integrative ice frozen assembly” focusing on the hierarchical structures and chemistries of functional nanomaterials such as, organic, inorganic, carbon, and composite materials for a rational design of energy application‐oriented materials is comprehensively reviewed. This integrative process allows functional nanomaterials to be assembled into various dimensions, such as, 0D, 1D, 2D, and 3D macrostructures, as well as, into larger bulk objects such as, fibers, films, monoliths, and powders. The fundamental understanding of the integrative ice frozen assembly is thermodynamically and kinetically discussed with the help of primitive freeze casting domain knowledge and the energy conversion and storage performances of the as‐designed electrodes with their hierarchical structures and chemistries are further correlated. The applications of the as‐assembled electrodes into batteries, supercapacitors, fuel cells, and electrocatalysis are also addressed. Finally, the perspective on the current impediments and future directions in this field is discussed.

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A review of multifunctional nacre-mimetic materials based on bidirectional freeze casting

Cited by 46 publications

References 97 publications

Anisotropic hair keratin‐dopamine composite scaffolds exhibit strain‐stiffening properties

Anisotropic hair keratin‐dopamine composite scaffolds exhibit strain‐stiffening properties

Strong and Tough Alumina Ceramic from the Particle‐Stabilized Foam

A New Era of Integrative Ice Frozen Assembly into Multiscale Architecturing of Energy Materials

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