A review of nanocellulose in the drug-delivery system

Tan, Tee How; Lee, Hwei Voon; Dabdawb, Wageeh Abdulhadi Yehya; Hamid, Sharifah Bee Binti O.A Abd

doi:10.1016/b978-0-12-816913-1.00005-2

Cited by 31 publications

(23 citation statements)

References 113 publications

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“…(Lin and Dufresne, 2014;Trache, 2018;Bacakova et al, 2019;Karimian et al, 2019;Moohan et al, 2020). Some important applications will be discussed below, whereas detailed discussions dealing with other medical uses of CNC-based materials can be found in other reviews (Golmohammadi et al, 2017;Grishkewich et al, 2017;Reiniati et al, 2017;Phanthong et al, 2018;Seabra et al, 2018;Wohlhauser et al, 2018;Bacakova et al, 2019;Carvalho et al, 2019;Du et al, 2019;Dufresne, 2019;Jin et al, 2019;Luo et al, 2019;Naz et al, 2019;Pires et al, 2019;Salimi et al, 2019;Sharma and Bhardwaj, 2019;Shojaeiarani et al, 2019;Tan et al, 2019;Younas et al, 2019;Mokhena and John, 2020;Moohan et al, 2020).…”

Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

“…Efficient drug delivery systems exhibit important features such as targeting, improved solubility, controlled drug release, reduced clearance, drug stability, and therapeutic effect. Some endeavors have been devoted to utilize CNCs as an appropriate pharmaceutical excipient and carrier owing to their colloidal stability, high surface-to-volume ratio and the negative surface charge, which allowed loading charged/neutral drugs, controlling the release of active compounds, and transporting the genes to the target cells (George and Sabapathi, 2015;Grishkewich et al, 2017;Tan et al, 2019). However, the hydrophilic character and the low drug-loading behavior of CNCs limit it use in pristine form.…”

Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

“…The search of novel applications and improving the properties of the current nanocellulose-based materials are crucial driving forces for research and development (R&D) in various research groups and increasingly in companies. It can be seen that several literature review articles have been published during the last few years and most of them focused on the production of nanocelluloses, their modification and applications (Dufresne, 2019;He et al, 2019;Karimian et al, 2019;Kim J. H. et al, 2019;Luo et al, 2019;Miao and Hamad, 2019;Naz et al, 2019;Park et al, 2019;Salimi et al, 2019;Shojaeiarani et al, 2019;Tan et al, 2019;Younas et al, 2019;Köse et al, 2020;Mokhena and John, 2020;Moohan et al, 2020;Tong et al, 2020). Certain recent findings and advances have not been enough addressed in previous publications, while here, we concisely provide some of the most recent applications of nanocellulose (NC), especially cellulose nanocrystals (CNC).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanocellulose: From Fundamentals to Advanced Applications

et al. 2020

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Over the past few years, nanocellulose (NC), cellulose in the form of nanostructures, has been proved to be one of the most prominent green materials of modern times. NC materials have gained growing interests owing to their attractive and excellent characteristics such as abundance, high aspect ratio, better mechanical properties, renewability, and biocompatibility. The abundant hydroxyl functional groups allow a wide range of functionalizations via chemical reactions, leading to developing various materials with tunable features. In this review, recent advances in the preparation, modification, and emerging application of nanocellulose, especially cellulose nanocrystals (CNCs), are described and discussed based on the analysis of the latest investigations (particularly for the reports of the past 3 years). We start with a concise background of cellulose, its structural organization as well as the nomenclature of cellulose nanomaterials for beginners in this field. Then, different experimental procedures for the production of nanocelluloses, their properties, and functionalization approaches were elaborated. Furthermore, a number of recent and emerging uses of nanocellulose in nanocomposites, Pickering emulsifiers, wood adhesives, wastewater treatment, as well as in new evolving biomedical applications are presented. Finally, the challenges and opportunities of NC-based emerging materials are discussed.

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Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanocellulose: From Fundamentals to Advanced Applications

et al. 2020

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“…For example, Liu et al studied the cell functions on CNFbased porous materials using epithelial-derived and hematopoietic-derived cells obtaining outstanding results for cell growth, survival, and proliferation, making these materials good candidates for tissue engineering applications [104]. Nanocellulose was also reported to be promising as drug delivery system [105]. For example, Valo et al used CNF-based aerogels from different cellulose sources for the immobilization of beclomethasone dipropionate nanoparticles for oral drug delivery systems [106].…”

Section: Nanocellulose Aerogels Application Perspectivesmentioning

confidence: 99%

Biorefinery Approach for Aerogels

et al. 2020

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According to the International Energy Agency, biorefinery is “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (fuels, power, heat)”. In this review, we survey how the biorefinery approach can be applied to highly porous and nanostructured materials, namely aerogels. Historically, aerogels were first developed using inorganic matter. Subsequently, synthetic polymers were also employed. At the beginning of the 21st century, new aerogels were created based on biomass. Which sources of biomass can be used to make aerogels and how? This review answers these questions, paying special attention to bio-aerogels’ environmental and biomedical applications. The article is a result of fruitful exchanges in the frame of the European project COST Action “CA 18125 AERoGELS: Advanced Engineering and Research of aeroGels for Environment and Life Sciences”.

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“…Nanostructured cellulose (nanocrystalline cellulose, NCC) has unique chemical, physical and optical characteristics, making it a beneficial and highly indemand nanomaterial as a value-adding additive and reinforcing agent. These promising properties, together with its low cost and sustainability, have attracted growing interest and wide-opened its potential applicability as an effective nano-additive and nanofillers in cosmetics, polymer composites, functional materials and thermoplastic materials (Robles et al, 2017;Tan et al, 2019). The current NCC production are generally carried out by either chemical conversion, enzymatic conversion, or mechanical conversion, with the chemical conversion being the most widely used method (Thomas et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An Overview of Recent Developments in Hetero-Catalytic Conversion of Cellulosic Biomass

Ahmed-Haras

Kao

Islam

et al. 2020

Res Com Eng Sc Tech

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In recent years, research activities involved in the production of nanocellulosic materials have grown substantially, rapidly stimulating the development of innovative production techniques. These materials are chemically extracted by acid-catalyzed Hydrolysis of the renewable and widely available cellulosic biomass. In this regard, sulfuric acid-catalyzed Hydrolysis of cellulosic biomass is a commonly known method for the production of nanostructured cellulose. However, this method may result in many disadvantages, including short catalyst-lifetime, corrosive to the reactor materials and managing the spent sulfuric acid resulted from the production process. This dictates the implementation of an eco-industrial alternative for the catalytic production of nanocrystalline cellulose (NCC). A viable and practical alternative is the application of heterogeneous (solid acids) catalysts, which can be more conducive in providing favorable platforms for efficient cellulose hydrolysis. This review highlights the current production methods of nanocrystalline cellulose. Further, recent literature on the heterogeneous-catalytic conversion of cellulosic biomass is briefly discussed. The limitations and disadvantages of these techniques are also described.

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A review of nanocellulose in the drug-delivery system

Cited by 31 publications

References 113 publications

Nanocellulose: From Fundamentals to Advanced Applications

Nanocellulose: From Fundamentals to Advanced Applications

Biorefinery Approach for Aerogels

An Overview of Recent Developments in Hetero-Catalytic Conversion of Cellulosic Biomass

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