A review of NIR dyes in cancer targeting and imaging

Luo, Shenglin; Zhang, Erlong; Su, Yongping; Cheng, Tianmin; Chen, Shi

doi:10.1016/j.biomaterials.2011.06.024

Cited by 1,280 publications

(1,023 citation statements)

References 166 publications

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“…Recently, indocyanine green (ICG)-enhanced fluorescence has been used to improve visualization and to provide detailed anatomical information during different surgical procedures, especially laparoscopic surgery (1)(2)(3)(4)(5)(6)(7)(8). Fluorescent optical guidance minimizes inadvertent tissue injury while enhancing procedural efficiency (9).…”

Section: Introductionmentioning

confidence: 99%

“…Indocyanine green is a water-soluble anionic amphiphilic tricarbocyanine dye with a molecular weight of 774.96 Da (1)(2)(3)(4)(5)(6)(7)(8)(9). This dye can be injected into the human bloodstream with practically no adverse effects (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and becomes fluorescent upon excitation by a laser beam or by light with a wavelength in the near infra-red (NIR) spectrum (approximately 820 nm).…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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Identification of the parathyroid glands during thyroid surgery may prevent their inadvertent surgical removal and thus provide a better postoperative quality of life. Nevertheless, the most common "technique" for intraoperative evaluation of perfusion of parathyroid gland tissues during thyroid surgery is visual inspection of the physical condition of tissues, e.g., their color and bleeding edges. Another technique is measurement of intact parathyroid hormone. Recently, indocyanine green-enhanced fluorescence has been used in various surgical techniques, particularly laparoscopic surgery, to improve visualization and to provide detailed anatomical information. Fluorescent optical guidance helps surgeons to avoid inadvertent tissue injury while enhancing procedural efficiency. This technique has potential use for evaluating perfusion of the parathyroid gland in real-time intraoperative angiography.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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“…NIR fluorescence technology can minimize background interference, improve tissue depth penetration and tumor contrast. Shi et al [75] reported the newly developed NIR dyes or NIR dye-encapsulated nanoparticles by conjugation with tumor specific ligands and their potential applications in cancer targeting and imaging. The potential of NIR dyes was assessed in photodynamic therapy (PDT) for a skin cancer model in vivo.…”

Section: Photosensitizers As Selective Therapeutic and Imaging Agentsmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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“…Various long-wavelength fluorescent dyes have been synthesized, with fluorescence maxima ranging from 700 to approximately 850 nm [14]. We recently developed a functional MPM, PTD-ODD-HaloTagdoi:10.7243/2050-120X-2-2 -1α (548-603), and a HaloTag (HT) that is easily conjugated with any chemical through covalent binding of HT and its ligand.…”

Section: Introductionmentioning

confidence: 99%

Importance of the physicochemical properties of fluorescent dyes for obtaining target-specific in vivo images by membrane-permeable macromolecular imaging probes

Kuchimaru¹,

Kadonosono²,

Corona³

et al. 2013

J Pharm Technol Drug Res

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Background: Membrane-permeable macromolecular (MPM) probes are designed to deliver functional proteins to disease sites and into cells by using protein transduction domain (PTD). To visualize intracellular molecular events in tumor sites, we previously developed MPM imaging probes conjugated with near-infrared fluorescence (NIRF) dyes. However, the factors which influence target-specific in vivo fluorescence images of MPM imaging probes are still unclear. We studied whether the physicochemical properties of NIRF dye significantly affect the in vivo images of MPM imaging probes. Methods: We constructed three MPM imaging probes conjugated with NIRF dyes including IRDye800, AlexaFluor750 and the newly synthesized PBI3921 and compared their biodistribution in tumor-bearing mice using in vivo optical imaging. In addition, we addressed to reveal relationships between biodistribution of MPM imaging probes and conjugated NIRF properties. Results: In vivo images obtained by three MPM probes were spatiotemporally different each other. These probes (~46 kDa) are different only in their NIRF dyes (~2 kDa), which have different physicochemical properties including surface charge and hydrophobicity based on chromatograph analyses. Moreover, the results of clearance efficiency obtained by using cancer cells were not necessarily correlated with the ones obtained by using mouse models. Conclusions: We concluded that physicochemical properties of NIRF dyes do affect the in vivo off-target images after injection of MPM imaging probes and that clearance of non-specific image may be predicted by the analysis of the property of a fluorescent dye conjugated to MPMs. These results would provide useful information to design MPM imaging probes with high target specificity in vivo.

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A review of NIR dyes in cancer targeting and imaging

Cited by 1,280 publications

References 166 publications

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Importance of the physicochemical properties of fluorescent dyes for obtaining target-specific in vivo images by membrane-permeable macromolecular imaging probes

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