A review of non-biodegradable alloys implantation induced inflammatory and immune cell responses

Xu, Lin; Wei, Canshen; Deng, Liang; Wang, Pei; Zhong, Wei; Huang, Wenhua

doi:10.1016/j.jallcom.2023.173086

Cited by 5 publications

(2 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The particles of Ti alloy were found to cause granulomas as peri-implant lesions due to the secretion of TNF-α and IL-6 pro-inflammatory macrophage. 43,44 In addition, the release of IL-1 and TNF-α from macrophages can activate the osteolytic process of peri-implantitis. 45 Figure 1 depicts the Ti implant and the activated macrophages which cause inflammatory reactions.…”

Section: Clinical Challenge Of Ti-based Implantmentioning

confidence: 99%

See 1 more Smart Citation

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

View full text Add to dashboard Cite

Metallic dental implants have been extensively used in clinical practice due to their superior mechanical properties, biocompatibility, and aesthetic outcomes. However, their integration with the surrounding soft tissue at the mucosal region remains challenging and can cause implant failure due to the peri-implant immune microenvironment. The soft tissue integration of dental implants can be ameliorated through different surface modifications. This review discussed and summarized the current knowledge of topography-mediated immune response and topography-mediated antibacterial activity in Ti dental implants which enhance soft tissue integration and their clinical performance. For example, nanopillar-like topographies such as spinules, and spikes showed effective antibacterial activity in human salivary biofilm which was due to the lethal stretching of bacterial membrane between the nanopillars. The key findings of this review were (I) cross-talk between surface nanotopography and soft tissue integration in which the surface nanotopography can guide the perpendicular orientation of collagen fibers into connective tissue which leads to the stability of soft tissue, (II) nanotubular array could shift the macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) and manipulate the balance of osteogenesis/osteoclasia, and (III) surface nanotopography can provide specific sites for the loading of antibacterial agents and metallic nanoparticles of clinical interest functionalizing the implant surface. Silver-containing nanotubular topography significantly decreased the formation of fibrous encapsulation in per-implant soft tissue and showed synergistic antifungal and antibacterial properties. Although the Ti implants with surface nanotopography have shown promising in targeting soft tissue healing in vitro and in vivo through their immunomodulatory and antibacterial properties, however, long-term in vivo studies need to be conducted particularly in osteoporotic, and diabetic patients to ensure their desired performance with immunomodulatory and antibacterial properties. The optimization of product development is another challenging issue for its clinical translation, as the dental implant with surface nanotopography must endure implantation and operation inside the dental microenvironment. Finally, the sustainable release of metallic nanoparticles could be challenging to reduce cytotoxicity while augmenting the therapeutic effects.

show abstract

Section: Clinical Challenge Of Ti-based Implantmentioning

confidence: 99%

“…Reprinted from J Alloy Comp, Volume: 977, Xu L, Wei C, Deng L, Wang P, Zhong W, Huang W. A review of non-biodegradable alloys implantation induced inflammatory and immune cell responses. 173086, Copyright 2024, with permission from Elsevier 44.…”

mentioning

confidence: 99%

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Effect of Anodic Oxidation on Antibacterial Properties and Biocompatibility of Ti‐13Nb‐13Zr‐3Cu for Biomedical Application

Xu,

Hu,

Liu

et al. 2024

Adv Eng Mater

View full text Add to dashboard Cite

Ti‐13Nb‐13Zr (TNZ), a representative of β‐type titanium alloys, has garnered significant interest in biomedical implant materials recently because of its high strength, and closer elastic modulus to human bone. However, TNZ alloy does not have antibacterial properties and has the potential to cause implant‐related infection, even implantation failure. Herein, TNZ alloy is alloyed by Cu element and the surface is modified by anodic oxidation (AO) to enhance the biocompatibility and antimicrobial qualities. The corrosion resistance, antimicrobial properties, and cytotoxicity of the TNZ‐3Cu alloy before and after anodization are studied by X‐ray diffraction, X‐ray photoelectron spectroscopy, scanning electron microscopy, electrochemical test, mechanical property test, and cell test. The experimental results show that the primary constituents of the TNZ‐3Cu alloy are α″ martensite and β phase after solid solution treatment. The elastic modulus of TNZ‐3Cu alloy is (65 ± 1.33) GPa, 9 GPa lower than that of TNZ alloy. The AO treatment significantly improves the hydrophilicity and antibacterial properties as well as the corrosion resistance by the formation of a dense oxides composites coating. The cell test results show that the coating improves the initial adhesion of cells by the high hydrophilic surface and promotes the proliferation of cells by the release of copper ions.

show abstract

Strengthening Zn–Ag alloys with Mg addition

Zhuo,

Huang,

Huang

et al. 2024

J. Iron Steel Res. Int.

View full text Add to dashboard Cite

A review of non-biodegradable alloys implantation induced inflammatory and immune cell responses

Cited by 5 publications

References 130 publications

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Effect of Anodic Oxidation on Antibacterial Properties and Biocompatibility of Ti‐13Nb‐13Zr‐3Cu for Biomedical Application

Strengthening Zn–Ag alloys with Mg addition

Contact Info

Product

Resources

About