A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action

Abstract

Eicosanoid signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the perception of pain and to cell survival itself. Disruption of normal eicosanoid signaling is implicated in numerous disease states. Eicosanoid signaling is facilitated by G-protein-coupled, eicosanoid-specific receptors and the array of associated G-proteins. This review focuses on the expression, characterization, regulation, and mechanism of action of non-prostanoid, eicosanoid receptors.

Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation

“…By conducting LC-MS on separated cell cultures and supernatants, we would be able to better understand not only how cSiO 2 impacts overall oxylipin production but also how cSiO 2 impacts individual oxylipin release from FLAMs. Accordingly, prostaglandins, thromboxanes, leukotrienes, HFAs, and other subclasses of oxylipins elicit biological activity through transmembrane G protein-coupled receptors (GPCRs) and intracellular receptors such as PPARg (108)(109)(110)(111)(112). While receptormediated biological effects have been reported-some proinflammatory and some pro-resolving-for numerous individual oxylipins (Supplementary Table 6), it is very likely that oxylipins elicit their biological activity as mixtures.…”

Editorial: A year in review: discussions in cellular endocrinology

“…The minireview by Stojilkovic and Balla entitled “PI ( 3 , 4 ) P2-dependent and -independent roles of PI4P in the control of hormone secretion by pituitary cells” focuses on the roles of the phosphoinositides phosphates (PIPs) PI4P, PI ( 3 , 4 ) P2, and PI ( 3 – 5 ) P3 in pituitary cell signaling and hormone secretion. PIPs play multiple roles in pituitary cell hormone secretion regulation.…”

“…PIPs are also involved in the regulation of multiple intracellular signaling pathways such as phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), and multiple ion channels gating, which are all involved in pituitary cells hormone secretion regulation. Additionally, Stojilkovic and Balla review some perplexing direct functions of PI4P, independent of its conversion to PI ( 3 , 4 ) P2, and PI ( 3 – 5 ) P3, in pituitary cell hormone exocytosis and secretion regulation. The pituitary gland is a master regulator of human physiology, and a better understanding of the molecular and cellular mechanisms of hormone secretion regulation is critical to tackle the multiple diseases caused by pituitary dysfunction ( 5 ).…”

“…One of the mechanisms addressed is mitochondrial dynamics, including both fusion and fission, which are cellular processes involved in multiple cellular functions, including adrenal steroidogenesis, and the culprit of numerous human diseases ( 3 ). Another mechanism is arachidonate 5-lipoxygenase (ALOX5)-generated arachidonic acid-derived lipid mediators that stimulate steroid biosynthesis via the oxoeicosanoid receptor 1 (OXER1) ( 4 ). Finally, Mori Sequeiros Garcia et al.…”

Targeting prostacyclin: all gain with no pain?

“…The promiscuity of prostaglandin analogs has been a challenge to the development of drug analogs. 5 Currently available antithrombotic agents remain limited by their propensity to cause bleeding that may be life-threating. These authors assessed the effects of CS585 on tail bleeding times in mice and thromboelastography (TEG) parameters in human whole blood.…”