A Review of OCT Angiography in Glaucoma

Werner, Astrid C; Shen, Lucy Q.

doi:10.1080/08820538.2019.1620807

Cited by 56 publications

(45 citation statements)

References 55 publications

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“… 5 In recent research, this method has been reported to provide easy diagnosis and follow-up in ocular diseases, including diabetic retinopathy and glaucoma. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

İçel¹,

Yılmaz²,

Uçak³

et al. 2020

tjo

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Objectives: To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL). Materials and Methods: A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the OCTA device, foveal avascular zone (FAZ) area, vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, and the VD of the radial peripapillary capillary plexus (RPCP) of the optic disc were recorded. Results: The mean age of the study group was 11.27±3 years, the mean AL was 23.39±1.18 mm and the mean SE was -1.31±1.61 diopters. The mean FAZ area was 0.3±0.09 mm 2 , the mean SCP-VD was 43.88±3.4%, the mean DCP-VD was 39.6±3.55%, and the mean RPCP-VD was 52.47±3.42%. When the relationship between the OCTA measurements and the SE and AL values were analyzed, there was no statistical significance (p>0.05). When age and OCTA measurements were compared, only DCP-VD values were found to significantly decrease with increasing age (p=0.015). There was no significant difference in OCTA measurements based on gender (p>0.05). Similarly, no statistical age-based differences were observed in RNFLT, CMV and CMT values (p>0.05). Conclusion: With its short procedure time and no dye requirement, OCTA can be safely used in the evaluation of the optic disc and macular perfusion in children. Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.

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“… 5 In recent research, this method has been reported to provide easy diagnosis and follow-up in ocular diseases, including diabetic retinopathy and glaucoma. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

İçel¹,

Yılmaz²,

Uçak³

et al. 2020

tjo

View full text Add to dashboard Cite

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“…[1][2][3] However, knowledge about the relationship between abnormal ocular perfusion and glaucoma is still scarce mainly because of limitations in determining optic nerve head (ONH) blood flow. 4,5 By optical coherence tomography angiography (OCTA), a recently introduced technique, the microcapillaries of the ONH and peripapillary region can be easily visualized without the need for dye injection. [4][5][6][7][8][9][10] This technique based on comparing B-scans via OCTA algorithms is able to detect red blood cell motions and can therefore be used to visualize microvascular flow.…”

Section: Introductionmentioning

confidence: 99%

“…8,9,[11][12][13] So far, OCTA has proved useful to evaluate ONH VD in patients with suspected or confirmed glaucoma. 5 The clinical relevance of taking peripapillary VD measurements is that the amount of VD reduction produced seems related to the extent of functional loss in glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Fernández‐Vigo

Kudsieh

Shi

et al. 2020

Current Eye Research

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Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 right eyes of healthy subjects. Peripapillary SS-OCTA VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in all four quadrants using the Triton device (Topcon, Nagoya, Japan). AL measurements were made by optical biometry. Results: Mean participant age was 37.7 ± 19.8 years (range 5-83), AL was 23.9 ± 1.3 mm (21-27), and 59% were women. Mean VDs for all quadrants were 57.2 ± 5.7% for SCP (52.4 ± 4.0% -62.1 ± 4.2%), 46.3 ± 6.5% for DCP (41.9 ± 5.8% -49.7 ± 4.8%) and 60.8 ± 7.4% for CC (53.4 ± 5.8% -65.7 ± 5.5%). Negative correlation was detected between SCP VD and age (R = −0.264; P < .001), while correlation between DCP densities and age was positive (R = 0.202; P = .002). No associations were detected between peripapillary VD and gender (P ≥ 0.087) and negative correlation was found with AL and disc area only in the CC (P ≤ 0.004). In a subgroup analysis of 33 individuals, we noted no differences in VD between fellow eyes (P ≥ 0.139). Conclusion: Peripapillary VD showed wide individual variation when measured with the Triton SS-OCTA in the different retinal plexuses and CC. While correlations were observed with age, no relationships emerged with gender and only CC showed negative correlation with AL and disc area.

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“…OCTA allows of repeatable, quantitative assessment of microcirculation in the macula and peripapillary [5,6]. The reduction of retinal vascular density (VD) within the macula and optic nerve head (ONH) has been repeatedly confirmed in patients with POAG [7][8][9][10][11]. Takusagawa et al observed with the use of projection-resolved OCTA focal capillary dropout in the macular superficial vascular plexus (SVP), but not the intermediate and deep vascular plexus (DVP) in glaucomatous eyes.…”

Section: Introductionmentioning

confidence: 99%

Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma

Zabel

Kaluzna

et al. 2020

PLoS ONE

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To evaluate the correlation between retinal sensitivity in microperimetry (MP) with vessel density (VD) using optical coherence tomography angiography (OCTA) in primary openangle glaucoma (POAG). Methods We enrolled 30 participants (52 eyes) with POAG and 15 participants (23 eyes) in the healthy control group. All participants were examined for retinal structure using OCTA to assess VD and Spectral domain OCT (SD-OCT) to assess ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness. Retinal sensitivity was tested with MP and standard automatic perimetry (SAP). Results The VD in moderate/severe POAG was lower than that in mild POAG and healthy control in the macular superficial vascular plexus (SVP) (38.7±6.3% vs. 42.9±5.2%, 49.7±2.6% respectively, P<0.001) and peripapillary radial peripapillary capillaries (pRPC) (36.4±5.7% vs. 43.6±6.6%, 49.1±2.4% respectively, P<0.001). The Pearson's correlations between function-structure parameters were strongest with MP average sensitivity threshold and SVP VD in the area of whole macula (r = 0.68); followed by SAP mean deviation (MD) and pRNFL thickness (r = 0.63); SAP MD and pRPC VD (r = 0.59) and MP average threshold and GCC thickness (r = 0.54). We found the AUROCs for discriminating between glaucomatous and healthy eyes were highest for structural parameters as follows: pRNFL (0.94),

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A Review of OCT Angiography in Glaucoma

Cited by 56 publications

References 55 publications

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma

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