A review of omics-based PFAS exposure studies reveals common biochemical response pathways

Beale, David J.; Sinclair, Georgia M.; Shah, Rohan; Paten, Amy M.; Kumar, Anu; Long, Sara M.; Vardy, Suzanne; Jones, Oliver A.H.

doi:10.1016/j.scitotenv.2022.157255

Cited by 48 publications

(29 citation statements)

References 113 publications

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“…31,32 Metabolite profiling has been used to study the impact of PFAS in plant and animal models. 4,32,33 Based on t test, none of the 27 metabolites quantified was significantly (p > 0.05) altered when E. fetida was exposed to PFAS for 7 d (compared to control). After 28 d of exposure, 0, 21, and 22 metabolites were significantly (p and FDR < 0.05) affected by exposure to PFOS, PFOA, and PFOS+PFOA, respectively (Tables S3-S5).…”

Section: Effect Of Pfas On Targeted Metabolites Of E Fetidamentioning

confidence: 99%

Perfluorooctanoic acid dominates the molecular-level effects of a trace mixture of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm

Han

Oyeyemi

Zenobio

et al. 2023

Preprint

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Per- and polyfluoroalkyl substances (PFAS) are an important class of emerging contaminants in the environment. Most studies on the impact of PFAS considered individual compounds; meanwhile PFAS mainly exist in soil as mixtures. To fill this knowledge gap, we investigated the impact of 200 ng/g of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS)as individual compounds and a binary mixture (PFOS+PFOA)on the survival, biomass, reproduction, and metabolites of earthworm (Eisenia fetida). PFAS significantly (p < 0.05) decreased the survival, biomass, and reproduction of E. fetida after 28 d of exposure, but the impact of the mixture was not additive. The bioaccumulation of PFOS after 28 d increased, while that of PFOA decreased when E. fetida was exposed to the mixture compared to the individual compounds. These bioaccumulation trends were partly attributed to changes in the soil distribution coefficient (Kd) of PFOS and PFOA when present in the mixture. Eighty percent of the statistically (p and FDR < 0.05) altered metabolites after 28 d were similarly perturbed by both PFOA and PFOS+PFOA. The pathways dysregulated are related to the metabolism of amino acids, energy, and sulfur. We showed that PFOA dominates the molecular-level impact of the binary PFAS mixture.

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Section: Effect Of Pfas On Targeted Metabolites Of E Fetidamentioning

confidence: 99%

Perfluorooctanoic acid dominates the molecular-level effects of a trace mixture of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm

Han

Oyeyemi

Zenobio

et al. 2023

Preprint

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“…For example, there is now a strong body of literature identifying behavioural effects to aquatic fauna from chemical mixtures, but this remains difficult to incorporate into existing water quality guidelines, even for individual chemicals (Ford et al 2021). Similarly, the use of tools such as omics can provide important insights in understanding potential environmental impacts as a line of evidence for signals (Beale et al 2022). Therefore, conducting environmental monitoring or managing chemicals only where hazards are understood with strong certainty, will result in continued delayed responses in managing chemicals.…”

Section: Cousins Et Al 2022)mentioning

confidence: 99%

Examining the utility of existing chemical hazard paradigms to predict future global-scale environmental impacts from emerging chemicals

Bowles

Beyer²

2022

Environ. Chem.

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Environmental context In previous instances of global impacts from chemicals, there were significant gaps between the onset of use and observations that triggered management. The lessons of the past have informed the development of strong paradigms for chemical management, but at some point, major impacts will again emerge, not covered by these paradigms. Holistic observation of the environment and collaborative reporting are needed to identify signals of future major issues. Abstract Increasing concern over per- and polyfluoroalkyl substances (PFAS) in the environment, in the last decade, has sparked an interest in emerging chemicals more broadly, leading to the development or strengthening of many useful programs for understanding and prioritising environmental hazards and risks for chemicals. While important and useful, such efforts mostly rely on comparing chemical properties with paradigms generated from previous environmental issues. The lessons of the past demonstrate that, at some point, major challenges to our existing paradigms will eventuate. Key to addressing these challenges is our ability for early identification of ‘blind spots’ not covered by our existing paradigms. Furthermore, if we only look for gross observable changes in the environment, we will only ever be able to respond with reactive measures. We suggest that while various relevant monitoring programs are in place and have been proposed, encouraging those processes to look beyond existing hazard paradigms and look for more subtle environmental signals will improve the ability to respond proactively when harm is still limited.

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“…However, it still has possibility to transform to terminal PFAS. Furthermore, the intermediate substances of precursors and degradation compounds seem to have higher toxicity, compared to original sources [4].…”

Section: Introductionmentioning

confidence: 98%

PFAS Characteristics and Treatment for Landfill Leachate

Chen¹

2023

HSET

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Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are manmade chemicals which has been extensively used, resulting in great potential for human and environmental accumulation due to high persistence. PFASs can be divided to two parts, terminal and precursor compounds, based on how many fluorine atoms link to the carbon bonds. Many studies have examined the removal ability of method including activated carbon (AC), Foam fractionation (FF), chemical oxidation and boron-doped diamond anodes (BBD). This paper focus on introducing advanced remedial technology for PFAS treatment from landfill leachate. The details about PFASs are introduced, including the chemical structure, source, and properties. Then, different types of PFASs from landfill leachate are demonstrated. Some of PFAS, especially short-chain, are prone to stay as liquid phase. Activated carbon, a great model of adsorption, shows excellent performance on removal of PFOS and PFOA. In addition, boron-doped diamond anodes technique which belongs to the electrochemical anodic oxidation, have a great potential on landfill leachate in the future. Last but not least, the conclusion makes a summary and shows possible treatment to landfill in the future.

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A review of omics-based PFAS exposure studies reveals common biochemical response pathways

Cited by 48 publications

References 113 publications

Perfluorooctanoic acid dominates the molecular-level effects of a trace mixture of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm

Perfluorooctanoic acid dominates the molecular-level effects of a trace mixture of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm

Examining the utility of existing chemical hazard paradigms to predict future global-scale environmental impacts from emerging chemicals

PFAS Characteristics and Treatment for Landfill Leachate

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