A Review of Patents and Innovative Biopolymer-Based Hydrogels

Ilić‐Stojanović, Snežana; Nikolić, Ljubiša; Cakić, Suzana

doi:10.3390/gels9070556

Cited by 18 publications

(9 citation statements)

References 126 publications

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“…Initially, polymer properties are the most important factor for providing a wide variety of drug controlled-release profiles, including drug sustained release [ 70 , 71 , 72 , 73 , 74 ]. Numerous reports in the literature have demonstrated that insoluble and biodegradable polymers and their composites and hybrids can be exploited as carriers to manipulate the gradual release of the loaded drug molecules [ 75 , 76 , 77 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Ji,

Zhao,

Liu

et al. 2023

Gels

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Sustained release is highly desired for “efficacious, safe and convenient” drug delivery, particularly for those anticancer drug molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat a hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the anticancer drug tamoxifen citrate (TC) and insoluble polymeric matrix ethylcellulose (EC). Compared with the electrosprayed TC-EC composite microparticles M1, the electrosprayed SA-coated hybrid microparticles M2 were able to provide an improved TC sustained-release profile. The 30% and 90% loaded drug sustained-release time periods were extended to 3.21 h and 19.43 h for M2, respectively, which were significantly longer than those provided by M1 (0.88 h and 9.98 h, respectively). The morphology, inner structure, physical state, and compatibility of the components of the particles M1 and M2 were disclosed through SEM, TEM, XRD, and FTIR. Based on the analyses, the drug sustained-release mechanism of multiple factors co-acting for microparticles M2 is suggested, which include the reasonable selections and organizations of lipid and polymeric excipient, the blank SA shell drug loading, the regularly round shape, and also the high density. The reported protocols pioneered a brand-new manner for developing sustained drug delivery hybrids through a combination of insoluble cellulose gels and lipid using modified coaxial electrospraying.

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Section: Resultsmentioning

confidence: 99%

Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Ji,

Zhao,

Liu

et al. 2023

Gels

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“…Soft porous natural materials represent very suitable materials for drug delivery systems, and silk-based biomaterials have shown different possibilities for tailoring such systems [ 3 , 91 , 103 , 109 , 125 ], including in the scope of bone tissue engineering [ 8 ]. Silk fibroin has shown good adjustability to suit different drug delivery systems, including hydrogels [ 116 , 117 , 121 ] or coatings and thin films [ 103 ]. Bioactivity and in vivo responses of silk proteins are important properties of the silk-based materials, utilized in this sense for tissue growth and remodeling [ 29 , 135 ].…”

Section: Spider Silk In Nanomedicinementioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.

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“…Small-molecule delivery systems have revolutionized materials science, agriculture, and biomedical research, offering an unparalleled ability to finely control the release kinetics of bioactive compounds [ 1 , 2 , 3 ]. Biopolymer-based controlled-release systems, among various strategies, have gained significant attention [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Controlled Release of Abscisic Acid (ABA) Utilizing Alginate–Chitosan Gel Blends: A Synergistic Approach for an Enhanced Small-Molecule Delivery Controller

Valdes,

Bustos,

Guzmán

et al. 2024

Gels

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The integration of abscisic acid (ABA) into a chitosan–alginate gel blend unveils crucial insights into the formation and stability of these two substances. ABA, a key phytohormone in plant growth and stress responses, is strategically targeted for controlled release within these complexes. This study investigates the design and characterization of this novel controlled-release system, showcasing the potential of alginate–chitosan gel blends in ABA delivery. Computational methods, including molecular dynamics simulations, are employed to analyze the structural effects of microencapsulation, offering valuable insights into complex behavior under varying conditions. This paper focuses on the controlled release of ABA from these complexes, highlighting its strategic importance in drug delivery systems and beyond. This controlled release enables targeted and regulated ABA delivery, with far-reaching implications for pharmaceuticals, agriculture, and plant stress response studies. While acknowledging context dependency, the paper suggests that the liberation or controlled release of ABA holds promise in applications, urging further research and experimentation to validate its utility across diverse fields. Overall, this work significantly contributes to understanding the characteristics and potential applications of chitosan–alginate complexes, marking a noteworthy advancement in the field of controlled-release systems.

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A Review of Patents and Innovative Biopolymer-Based Hydrogels

Cited by 18 publications

References 126 publications

Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Review of Spider Silk Applications in Biomedical and Tissue Engineering

The Controlled Release of Abscisic Acid (ABA) Utilizing Alginate–Chitosan Gel Blends: A Synergistic Approach for an Enhanced Small-Molecule Delivery Controller

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