2016
DOI: 10.4172/2329-6631.1000166
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A Review of Plant Sulfated Polysaccharides and their Relations with Anticoagulant Activities

Abstract: Heparin is an important therapeutic agent for the prophylaxis and treatment of thrombosis. Although effective, heparin can cause, among other adverse effects, bleeding and thrombocytopenia, being obtained from bovine lungs and porcine intestines, causing concern about contamination with pathogenic animal agents. This study aimed at reviewing the literature on the relationship between the sulfated polysaccharides isolated from plants and anticoagulant activity. Based on articles published between 2009 and 2016 … Show more

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Cited by 8 publications
(9 citation statements)
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“…Those anti-coagulants are obtained synthetically and cause side effects if used excessively. For example, long-term use of heparin causes bleeding of blood vessels in the brain and trombocytopenia (Gandasoebrata, 2013;Shobharani et al, 2014;Oliveira et al, 2016). In addition, the price of these materials is quite expensive so that the development of natural anti-coagulants from plant is very needed to minimize side effects at a more affordable price (Harter et al, 2014;Khouya et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Those anti-coagulants are obtained synthetically and cause side effects if used excessively. For example, long-term use of heparin causes bleeding of blood vessels in the brain and trombocytopenia (Gandasoebrata, 2013;Shobharani et al, 2014;Oliveira et al, 2016). In addition, the price of these materials is quite expensive so that the development of natural anti-coagulants from plant is very needed to minimize side effects at a more affordable price (Harter et al, 2014;Khouya et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Heparin is actively used in clinical practice. It is obtained from raw materials of animal origin, however, it can cause negative side effects on the human body and be a source of pathogenic microflora [3].…”
Section: Introductionmentioning
confidence: 99%
“…Polysaccharides can be chemically modified with sulfate groups, which can improve and also give them new biological properties. The biological activity of sulfated polysaccharides also depends on their molecular weight [3,4]. Complexes of sulfuric anhydride with various basic reagents have been widely used for sulfating polysaccharides.…”
Section: Introductionmentioning
confidence: 99%
“…Известно, что сульфатированные производные полисахаридов растительного происхождения могут составить перспективную альтернативу гепарину [2,[6][7][8][9][10][11]. Антикоагулянтная активность (АК) сульфатированных полисахаридов зависит от метода сульфатирования, влияющего на степень сульфатирования, характера и расположения сульфатных групп, молекулярной массы и др.…”
unclassified
“…Арабиногалактан (АГ) лиственницы, благодаря своим уникальным физико-химическим и фармакологическим свойствам, занимает особое место среди полисахаридов [11,16,17]. Макромолекула арабиногалактана, выделенного из древесины лиственницы сибирской, имеет разветвленную структуру и молекулярную массу порядка 15-20 кДа.…”
unclassified