A review of platelet-rich plasma for enteric fistula management

Abstract

Enteric fistula (EF), a serious complication after abdominal surgery, refers to unnatural communication between the gastrointestinal tract and the skin or other hollow organs. It is associated with infection, massive fluid/electrolyte loss, and malnutrition, resulting in an unhealed course. Despite advances in surgical techniques, wound care, infection control, and nutritional support, EF remains associated with considerable morbidity and mortality. Autologous platelet-rich plasma (PRP) containing elevated platelet concentrations has been proposed to promote healing in many tissues. However, the mechanism of action of PRP in EF treatment remains unclear owing to its complicated clinical manifestations. In this review, we summarized the clinical approaches, outlined the principal cytokines involved in the healing effects, and discussed the advantages of PRP for EF therapy. In addition, we defined the mechanism of autologous PRP in EF management, which is essential for further developing EF therapies.

The Difference in Severity of Temporomandibular Joint Disorders Before and After Jaw Exercises

“…Changes in any combination of teeth, periodontal ligaments, TMJ, or masticatory muscles can ultimately lead to TMD. The multifactorial etiology includes initiation factors (trauma, excessive chewing load, and bad oral habits), predisposing factors (systemic, genetic, structural, malocclusion, psychology), and perpetuation factors (metabolic factors, muscle tension) (Kaur & Datta, 2013) (Liang et al, 2023).…”