A review of polymers as multifunctional excipients in drug dosage form technology

Karolewicz, Bożena

doi:10.1016/j.jsps.2015.02.025

Cited by 88 publications

(60 citation statements)

References 66 publications

(101 reference statements)

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“…In addition to antimicrobial properties, BC contains immunoglobulins and lactoferrins which help in building up the immunity and protect against pathogenic bacteria proliferation and growth. The mucoadhesive polymers, for example agars, polyacrylates, pectins, sodium carboxymethyl cellulose and xanthan gum, constitute an important group of excipients employed when designing pharmaceutical forms such as tablets, capsules, suspensions and gels (Nallathambi & Gopal, 2014;Karolewicz, 2016). In vitro studies have demonstrated antibacterial activity of EOs against Listeria monocytogenes, Salmonella typhimurium, Escherichia coli O157:H7, Shigella dysenteria, Bacillus cereus and Staphylococcus aureus (Shahbazi, 2015;De Souza, 2016).…”

Section: Introductionmentioning

confidence: 99%

Development of antimicrobial gummy candies with addition of bovine colostrum, essential oils and probiotics

Bartkienė

Ružauskas

Lėlė

et al. 2017

Int J of Food Sci Tech

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Summary The aim of this study was to develop antimicrobial properties of gummy candies based on bovine colostrum (BC), essential oils (EOs), lactic acid bacteria (LAB) strains and their combinations. In addition, the heteropolysaccharide (agar), as a multifunctional polymer, was used for the antimicrobial candies preparation. The antimicrobial activities of BC, EOs (C. reticulata L., Eugenia caryophyllata, C. paradisi L., Thymus vulgaris), LAB strains (Lactobacillus plantarum LUHS135 and Lactobacillus paracasei LUHS244) and their combinations against pathogenic bacteria (Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Salmonella enterica, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans) were investigated. The highest antimicrobial activities were demonstrated by Thymus vulgaris and Eugenia caryophyllata EOs and their emulsions (12%), and the best formulation of components for antimicrobial gummy candies production would incorporate the BC fermented with L. paracasei LUHS244 in combination with Thymus vulgaris or Eugenia caryophyllata EOs, which inhibited growth of all the tested pathogenic microorganisms (except Pseudomonas aeruginosa). Gummy candies formula consisting of the fermented BC (up to 3%) and thyme EO (up to 0.2%) with mandarin or grapefruit EOs (up to 0.2%) for taste‐masking, allowed obtaining good texture and high overall acceptability products containing desirable antimicrobials, thus antimicrobial gummy candies could be consumer preferred form of nutraceuticals.

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Section: Introductionmentioning

confidence: 99%

Development of antimicrobial gummy candies with addition of bovine colostrum, essential oils and probiotics

Bartkienė

Ružauskas

Lėlė

et al. 2017

Int J of Food Sci Tech

View full text Add to dashboard Cite

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“…It can be incorporated into the lipid bilayers promoting a marking and also mimicking lipophilic drugs since they both exhibit a similar partition coefficient (log P). The confocal laser scanning microscopy study clearly revealed that the dye incorporated into the formulation showed better penetration across the intestinal mucosa as compared to the plain dye solution probably due to the small size of the formulation and presence of PVA which is a nonionic mucoadhesive polymer assuring greater interpenetration [18]. The specific darkening of the intracellular spaces proves the point that the uptake of the dye incorporated into the formulation principally occurred by trans cellular transport.…”

Section: Confocal Laser Scanning Microscopymentioning

confidence: 92%

“…Our data supports that a lower concentration of PVA (1% w/v) is suitable to obtain well-controlled particle size formulations provided stability of dispersion is not compromised. Analysing the response surface of interactions of PLGA and ethyl acetate at constant PVA, we found that initially, with an increase of solvent volume, the particle size did not change much and then decreased with further increase in the volume of ethyl acetate (trial [13][14][15][16][17][18][19][20].…”

Section: Influence On Particle Sizementioning

confidence: 99%

Polymeric Nanoparticles for Improved Bioavailability of Cilnidipine

Mishra

Mir

Amin

2017

Int J Pharm Pharm Sci

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Objective: In the present study, we aimed to optimize, characterize and evaluate poly lactic-glycolic acid nanoparticles of cilnidipine for improved permeation across the gastrointestinal tract.Methods: Poly lactic-glycolic acid-cilnidipine (PLGA-CIL) nanoparticles were prepared by an emulsification solvent evaporation/diffusion method using polyvinyl alcohol (PVA) as a surfactant. The prepared nanoparticles were successfully characterized for particle size, shape, drug release and pharmacological effect.Results: Polymeric nanoparticles of cilnidipine at a dose of 10 mg had a small particle size of 272 nm with smooth morphology. Nearly 81% of the drug was encapsulated in the polymeric structure and showed 18.99±0.59% of release at pH 1.2 within 3h, however, at pH 6.8 the release was 80.89±1.59%. The formulation had a better antihypertensive effect on methylprednisolone-induced hypertensive rats. The relative bioavailability of the nanoparticles was found to be 2.44 and 2.94 fold higher than the tablet and drug suspension respectively. Conclusion:The results demonstrated that the novel delivery system offers an effective strategy for treatment of hypertension.

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“…Forexample, nanoparticles with a hydrodynamic diameter of 5-100 nm have optimal pharmacokinetic properties for in vivo applications. [7][8][9][10] These polymeric nanoparticles are prepared from a variety of biocompatible polymers and can be formulated to transport pharmaceutical agents in a controlled and targeted fashion through further surface modification drugs and modulate dendrimer-drug interactions. 6 Now a days, polymeric nanoparticles have been extensively studied for their chemical and physical properties and widely used in drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

2016

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In the last several decades, researchers have focused on developing suitable drug carriers to deliver pharmaceutical agents to treat cancer diseases. PAMAM dendrimers have been studied as potential delivery systems to targeting, imaging, and/or deliver therapeutic agents specifically to diseased tissues because of their unique properties, such as: multiple functionalities at the periphery or in the cavity, biocompatibility, tunable size, and monodispersity. Anti-cancer agents may be incorporated into the interior void space or conjugated to the surface of PAMAM to enhance the delivery of cytotoxic drugs. In addition, targeting ligands can also be attached to the dendrimer surface to allow active targeting and minimize harm to normal cells. In summary, this review highlights the contributions of PAMAM dendrimers to the field of nanotechnology with the intent to aid researchers in exploring dendrimers for targeted drug delivery, contrasting and bio-image agents. with specific ligands. 11 As previously reviewed, several polymeric nanocarriers can be prepared from both natural polymers, such as albumin, hyaluronic acid, and chitosan, and synthetic polymers, such as poly acrylamide (PAA), poly lactic acid (PLA), poly glycolic acid (PGA), poly(lactide-co-glycolide) (PLGA) and dendrimers. 12The purpose of this review is to provide readers an overview of well-defined PAMAM dendrimer nanomaterials which are available and may be of interest for cancer-related medical applications such as drug delivery and bio-imaging modalities. Therefore, the current review mainly focuses on the recent publications related to the development of PAMAM dendrimers for targeting and bio-imaging-guided drug delivery, as well as multifunctional dendrimer nanocomplexes. A brief introduction is also given for the in vitro and in vivo diagnosis of cancer and with a brief concluding remarks as well as future prospects of the topic. DendrimerDendrimers are a family of 3D nano-sized macromolecules exhibiting highly branched architecture initially reported by Fritz Vogtle in 1978 and synthesized by Donald Tomalia and George R. Newkome in the 1980s. [13][14][15] The name "dendrimer" comes from two Greek words dendron, which means "tree branch like", and meros, which means "part of", and was first discovered by Tomalia et al. 13 Dendrimer is considered as the fourth new class of polymer structure, that demonstrates significant application in nanomedicine including drug delivery due to its unique platform for the construction of various multifunctional carriers. 14, 16-23 Poly (amidoamine) (PAMAM) dendrimers are a family of highly branched and monodispersed synthetic macromolecules with well-defined structure and composition. 24, 25 These polymers have internal cavities and peripheral functional groups that can be modified to better localize

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A review of polymers as multifunctional excipients in drug dosage form technology

Cited by 88 publications

References 66 publications

Development of antimicrobial gummy candies with addition of bovine colostrum, essential oils and probiotics

Development of antimicrobial gummy candies with addition of bovine colostrum, essential oils and probiotics

Polymeric Nanoparticles for Improved Bioavailability of Cilnidipine

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

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