Perfluorooctanoic acid (PFOA) is an artificially synthesized per-fluorinated chemical widely used in industry. It is often released into the environment without treatment and causes pollution in groundwater. In this paper, we employed a strip fountain dielectric barrier discharge (SF-DBD) plasma source to degrade PFOA from the water. The effects of power supply mode, discharge gases, pH, the conductivity of the solution, concentration, etc., on the degradation efficiency were studied. For a 200 mL sample of 75 mg/L PFOA, a 99% degradation efficiency with a 204.5 μg/kJ energy production rate was achieved using an average power of 43 W negative pulse argon plasma for 50 min at atmospheric pressure. The total organic carbon concentration (TOC) decreased by 63% after a 60-minute treatment. The SF-DBD proves to be a promising and energy-saving technique to efficiently remove PFOA from water.