A review of recent advances in quinoline/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies

Nasehi, Paria; Omidkhah, Negar; Ghodsi, Razieh

doi:10.1016/j.molstruc.2023.136720

Cited by 8 publications

(2 citation statements)

References 94 publications

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“…These quinoline compounds are multipurpose and have a variety of properties, such as anti-HIV, anti-Alzheimer, antibacterial, anti-malarial, antiviral, anti-inflammatory, anti-diabetic, anti-proliferative, antitumor, anti-platelet, anti-leishmanial, anti-tubercular, antioxidant, anticancer, anti-trypanosomal, anti-plasmodial, antimicrobial, anticonvulsant, and corrosion inhibition agents. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Although there are several techniques to build the structural core of quinolines, Friedländer annulation remains one of the most convenient and attractive methods for generating poly-substituted quinolines. Recent reports have described the synthesis of many quinoline analogues utilizing a range of catalysts, including phosphoric acid, GO, Fe 3 O 4 @SiO 2 /ISN/Cu (II), SiO 2 /H 2 SO 4 , [GrBen-zImi]SO 3 H, sulfated polyborate, Mn (CO) 5 Br, and PANEOSF.…”

Section: Introductionmentioning

confidence: 99%

“…The Povarov reaction has grown in significance and utility for the synthesis of quinoline derivatives in contemporary research. These quinoline compounds are multipurpose and have a variety of properties, such as anti‐HIV, anti‐Alzheimer, antibacterial, anti‐malarial, antiviral, anti‐inflammatory, anti‐diabetic, anti‐proliferative, antitumor, anti‐platelet, anti‐leishmanial, anti‐tubercular, antioxidant, anticancer, anti‐trypanosomal, anti‐plasmodial, antimicrobial, anti‐convulsant, and corrosion inhibition agents 15–33 . Although there are several techniques to build the structural core of quinolines, Friedländer annulation remains one of the most convenient and attractive methods for generating poly‐substituted quinolines.…”

Section: Introductionmentioning

confidence: 99%

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A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Rao,

Maddila,

Anantha

et al. 2024

Applied Organom Chemis

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This work aims to explore the catalytic potential of manganese oxide (MnO2) supported on (Fe3O4‐MWCNT) nano‐composite, which is composed of iron oxide and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simple impregnation technique. The catalyst material was extensively characterized using a variety of possible analytical methods, including X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X‐ray spectroscopy (EDS). Then, utilizing a multi‐component condensation protocol comprising substituted aldehydes, cyclohexadione, ethylacetoacetate, and NH4OAc, the catalytic efficacy of the Fe3O4‐MWCNT@MnO2 nano‐composite was assessed for synthesizing novel hexahydro‐quinoline analogues. The catalyst was found to be effective because of its huge specific surface area, stability, porosity, and distinctive exposed surfaces. The catalyst's surface exhibited an exceptionally active nature, as seen by the notably high turnover frequency. Herein, we present a reusable and effective catalytic method that produces outstanding product yields (93%–97%) under mild reaction conditions, using ethanol as a green solvent. Cost‐effectiveness, environmental safety, and high atom efficiency are achieved using the nano‐composite.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Rao,

Maddila,

Anantha

et al. 2024

Applied Organom Chemis

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Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Wang,

Wang

et al. 2024

Advanced Therapeutics

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Phytochemicals are a diverse class of compounds found in various plant‐based foods and beverages that have displayed the capacity to exert powerful anticancer effects through the induction of programed cell death (PCD) in malignancies. PCD is a sophisticated process that maintains in upholding tissue homeostasis and eliminating injured or neoplastic cells. Phytochemicals have shown the potential to induce PCD in malignant cells through various mechanisms, including modulation of cell signaling pathways, regulation of reactive oxygen species (ROS), and interaction with critical targets in cells such as DNA. Moreover, recent studies have suggested that nanomaterials loaded with phytochemicals may enhance cell death in tumors, which can also stimulate antitumor immunity. In this review, a comprehensive overview of the current understanding of the anticancer effects of phytochemicals and their potential as a promising approach to cancer therapy, is provided. The impacts of phytochemicals such as resveratrol, curcumin, apigenin, quercetin, and some approved plant‐derived drugs, such as taxanes on the regulation of some types of PCD, including apoptosis, pyroptosis, anoikis, autophagic cell death, ferroptosis, and necroptosis, are discussed. The underlying mechanisms and the potential of nanomaterials loaded with phytochemicals to enhance PCD in tumors are also explained.

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Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC

Jia,

Pei,

et al. 2024

European Journal of Medicinal Chemistry

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A review of recent advances in quinoline/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies

Cited by 8 publications

References 94 publications

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC

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A review of recent advances in quinoline/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies

Cited by 8 publications

References 94 publications

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe3O4‐MWCNT@MnO2 as a reusable catalyst

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe3O4‐MWCNT@MnO2 as a reusable catalyst

Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC

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Product

Resources

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A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst