2024
DOI: 10.3389/fmed.2024.1477988
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A review of recent clinical trials to evaluate disease-modifying therapies in the treatment of cardiac amyloidosis

Sindhuja Senigarapu,
James J. Driscoll

Abstract: Cardiac amyloidosis (CA) is a serious condition that results in infiltrative cardiomyopathy and heart failure with preserved ejection fraction (HFpEF) that is caused by the extracellular deposition of amyloid fibrils within heart tissue. While many important features of CA have been known for years, its prevalence in elderly patients with HF is increasingly being recognized. Plasma cells produce monoclonal immunoglobulin light chains which results in the formation and aggregation of amyloid fibrils that are re… Show more

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