A review of recent, unconventional applications of ion mobility spectrometry (IMS)

Armenta, Sergio; Alcalà, Manel; Blanco, M.

doi:10.1016/j.aca.2011.07.021

Cited by 217 publications

(123 citation statements)

References 111 publications

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“…IMS has several capabilities as a stand-alone instrument and has been used to monitor the detection of atmospheric compounds, (1 -3) explosives, (4 -6) chemical warfare agents (CWAs), (7,8) and petrochemical reagents. (3) In recent years, IMS technology has been used to detect explosives and narcotics in airport scanner devices. While it has been extremely effective in field applications as a stand-alone or portable device, the coupling of IMS with MS extends the capabilities and applications of the technique tremendously.…”

Section: Introductionmentioning

confidence: 99%

Ion Mobility‐Mass Spectrometry

Jiang

Robinson

2013

Encyclopedia of Analytical Chemistry

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Ion mobility spectrometry (IMS) separates ions based on their mobility in an inert buffer gas in the presence of an electric field. The mobility of ions is based on their size, shape, and charge, thus IMS provides insights into structure. In addition to being used for structural information, IMS can also be used as a separation device for complex mixtures. When coupled with mass spectrometry (MS), IMS–MS offers a powerful hybrid analytical technique that has many biological, pharmaceutical, structural, environmental, and other applications. This article provides an overview of IMS–MS, which focuses on principles of drift‐time ion mobility spectrometry (DTIMS), high‐field‐asymmetric ion mobility spectrometry (FAIMS), and traveling wave ion mobility spectrometry (TWIMS) methods. Several IMS–MS instruments are discussed and examples of the current applications of the technology are provided.

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Section: Introductionmentioning

confidence: 99%

Ion Mobility‐Mass Spectrometry

Jiang

Robinson

2013

Encyclopedia of Analytical Chemistry

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“…Most popular methodologies include gas chromatography coupled with mass spectrometry (GC-MS) [2], proton transfer reaction mass spectrometry (PTR-MS) [24], selected ion flow tube mass spectrometry (SIFT-MS) [17][18][19][20], and ion mobility spectrometry (IMS) [25]. Electronic noses [26] as intelligent chemical sensor array systems and laser spectroscopy [27] have also been applied in real-time measurements for breath and sweat analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, improvements on man-portable, field-deployable, or standoff devices are still needed. The most important technologies for threat detection can be summarized as follows: spectrometry (mass spectrometry (MS) [29], ion mobility spectrometry (IMS) [25]), optical methods, terahertz (THz) [30], infra-red (IR) [31], X-radiation [32], laser spectroscopy, light detection and ranging (LIDAR), cavity ring down spectroscopy (CRDS), Raman [8], electronic noses (EN) [33], sensors (chemical, immunochemical, electrochemical, and fiber-optic) and nanotechnology (e.g., nanoparticles or nanotubes)-based techniques [8].…”

Section: Introductionmentioning

confidence: 99%

Membrane Inlet Mass Spectrometry for Homeland Security and Forensic Applications

Giannoukos

Brkić

Taylor

2014

J. Am. Soc. Mass Spectrom.

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Abstract. A man-portable membrane inlet mass spectrometer has been built and tested to detect and monitor characteristic odors emitted from the human body and also from threat substances. In each case, a heated membrane sampling probe was used. During human scent monitoring experiments, data were obtained for inorganic gases and volatile organic compounds emitted from human breath and sweat in a confined space. Volatile emissions were detected from the human body at low ppb concentrations. Experiments with compounds associated with narcotics, explosives, and chemical warfare agents were conducted for a range of membrane types. Test compounds included methyl benzoate (odor signature of cocaine), piperidine (precursor in clandestine phencyclidine manufacturing processes), 2-nitrotoluene (breakdown product of TNT), cyclohexanone (volatile signature of plastic explosives), dimethyl methylphosphonate (used in sarin and soman nerve agent production), and 2-chloroethyl ethyl sulfide (simulant compound for sulfur mustard gas). Gas phase calibration experiments were performed allowing sub-ppb LOD to be established. The results showed excellent linearity versus concentration and rapid membrane response times.

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“…Introduced in the 1960s as an analytical technique to separate and analyze gas phase ions at atmospheric pressure (Eiceman and Karpas 2005 ), ion mobility spectrometers have been developed from fast, sensitive and portal detectors for illegal drugs, explosives, and chemical warfare agents in early stages (McDaniel and Mason 1973, Asbury et al 2000, Ewing et al 2001, Eiceman 2002, Makinen et al 2010 ) over analyzers of non-volatile and labile samples via electrospray ionization-ion mobility spectro metry (ESI-IMS) (Tang et al 2006, Jafari et al 2011, introduced in the late 1980s to analyzers of metabolomes and proteomes if combined with mass spectro metry (McMinn et al 1990, W ü thrich 1993, Chiarello -Ebner 2006, Eckers et al 2007, Liu et al 2007, McLean et al 2007, Waltman et al 2008, Djidja et al 2009, Krueger et al 2009, Armenta et al 2011. In more modern applications, even the study of protein-protein and non-covalent proteinligand complexes is possible (Ruotolo et al 2008, Politis et al 2010.…”

Section: Introductionmentioning

confidence: 99%

Pulsed electron beams in ion mobility spectrometry

Baether¹,

Zimmermann²,

Gunzer³

2012

Reviews in Analytical Chemistry

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Abstract:Ion mobility spectrometry is a well-known technique used to analyze trace gases in ambient air. Typically, it works by employing a radioactive source to provide electrons with high energy to ionize the analytes in a series of chemical reactions. During the past ten years non-radioactive sources have been one of the subjects of interest in ion mobility spectrometry, initially in order to replace radioactive sources as a result of general security and regulatory concerns. Among these non-radioactive sources especially pulsed sources have recently been shown to additionally improve the analytic information provided by ion mobility spectrometers. In this review we will describe the progress regarding the application of pulsed non-radioactive electron sources in ion mobility spectrometry and show the recent analytical advances that have been achieved by using pulsed electron beams.

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A review of recent, unconventional applications of ion mobility spectrometry (IMS)

Cited by 217 publications

References 111 publications

Ion Mobility‐Mass Spectrometry

Ion Mobility‐Mass Spectrometry

Membrane Inlet Mass Spectrometry for Homeland Security and Forensic Applications

Pulsed electron beams in ion mobility spectrometry

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