A Review of Repercussions of Lithium Amalgamated with Antipsychotics for the Remedy of Bipolar Disorder

Abstract

Bipolar disorder is a brain illness that causes mood, energy, and ability to function variations. Bipolar illness patients have extreme emotional states that often occur over a period of days to weeks, referred to as mood episodes. Manic/hypomanic (abnormally cheerful or angry mood) or depressed (sad mood) mood episodes are classified. People with bipolar disorder frequently have periods of neutral mood. People with bipolar disorder can live long and productive lives if they are treated. The management of BD may be summarized into 2 phases, acute treatment and long-term prevention. Lithium was observed to have a unique therapeutic profile, including mood-stabilizing effects, as well as anti-suicidal and neuroprotective properties.13 It is available in many different salt forms, namely lithium carbonate, lithium citrate, lithium chloride, and lithium sulfate. A meta-analysis discovered that a combination regimen of haloperidol, olanzapine, risperidone, and quetiapine was substantially more effective in treating BD manic episodes than monotherapy with a mood stabiliser, but the combination regimen was less well tolerated than monotherapy.
 Keywords: Bipolar Disorder, Lithium, Monotherapy, Combination therapy, Adverse effects.