A review of reproductive health research, guidelines and related gaps for women living with HIV

Loutfy, Mona; Sonnenberg-Schwan, U.; Margolese, Shari; Sherr, Lorraine

doi:10.1080/09540121.2012.733332

Cited by 30 publications

(20 citation statements)

References 50 publications

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“…Among HIV-positive women, the high rate of unintended pregnancy questions the predominance of condoms as the main contraceptive method [13,31]. Such predominance might be related to the threat of HIV transmission to sexual partners, which is at the heart of sexual and reproductive concerns for people living with HIV PLWHIV [32].…”

Section: Discussionmentioning

confidence: 99%

“…Condoms have been found to be the most widespread contraception method among women living with HIV in western countries; however, the inconsistent use of condoms remains widespread [9], and the use of highly effective methods has remained rare [10]. Above all, high rates of unintended pregnancy have been registered among women living with HIV (ranging from 50% to 85%) [11][12][13], suggesting unmet needs for contraception.…”

Section: Introductionmentioning

confidence: 99%

“…It aims to assess the extent to which this pattern is related to HIV infection characteristics, to reproductive and sexual factors, to social situations [13,14] and to accessibility to reproductive health services.…”

Section: Introductionmentioning

confidence: 99%

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Women living with HIV still lack highly effective contraception: results from the ANRS VESPA2 study, France, 2011

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Women living with HIV still lack highly effective contraception: results from the ANRS VESPA2 study, France, 2011

et al. 2015

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“…Such laws may in fact harm women rather than assist them and have a negative impact on public health and human rights [104, 105]. Reproductive health for WLWH is another important topic that we have reviewed in a separate publication [106]. …”

Section: Sexual Health In Wlwhmentioning

confidence: 99%

Caring for women living with HIV: gaps in the evidence

Loutfy

Sherr

Sonnenberg-Schwan³

et al. 2013

Journal of the International AIDS Society

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IntroductionIn the management of HIV, women and men generally undergo the same treatment pathway, with gender differences being given limited consideration. This is in spite of accumulating evidence that there are a number of potential differences between women and men which may affect response to treatment, pharmacokinetics, toxicities and coping. There are also notable psychological, behavioural, social and structural factors that may have a unique impact on women living with HIV (WLWH). Despite our increasing knowledge of HIV and advances in treatment, there are significant gaps in the data relating specifically to women. One of the factors contributing to this situation is the under-representation of women in all aspects of HIV clinical research. Furthermore, there are clinical issues unique to women, including gynaecologic and breast diseases, menopause-related factors, contraception and other topics related to women's and sexual health.MethodsUsing scoping review methodology, articles from the literature from 1980 to 2012 were identified using appropriate MeSH headings reflecting the clinical status of WLWH, particularly in the areas of clinical management, sexual health, emotional wellbeing and treatment access. Titles and abstracts were scanned to determine whether they were relevant to non-reproductive health in WLWH, and papers meeting inclusion criteria were reviewed.ResultsThis review summarizes our current knowledge of the clinical status of WLWH, particularly in the areas of clinical management, sexual health, emotional wellbeing and treatment access. It suggests that there are a number of gender differences in disease and treatment outcomes, and distinct women-specific issues, such as menopause and co-morbidities, that pose significant challenges to the care of WLWH.ConclusionsBased on a review of this evidence, outstanding questions and areas where further studies are required to determine gender differences in the efficacy and safety of treatment and other clinical and psychological issues specifically affecting WLWH have been identified. Well-controlled and adequately powered clinical studies are essential to help provide answers to these questions and to contribute to activities aimed at improving the health and wellbeing of WLWH.

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“…3,4 There is little information on the impact of antiretroviral drugs exposure on children born to women infected with HIV from early childhood. In order to respond to this problem, the Romanian Registry on Mother to Child HIV Transmission was started in 2014.…”

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confidence: 99%

Birth outcome in HIV vertically-exposed children in two Romanian centers

Mărdărescu

Petre

et al. 2015

GERMS

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Background The Romanian HIV epidemic is characterized by a high prevalence among children born in the late '80s, perinatally infected. The impact of long-term treatment on their offspring is unknown. We evaluated the influence of prenatal care on the rate of premature birth among the HIV-exposed children of heavily treated HIV-infected mothers in two Romanian centers.Methods We retrospectively analyzed data on all patients born by HIV-infected mothers between 2006 and 2012 followed up in two main regional centers. We compared the rate of premature birth and the differences between the sites regarding children and maternal demographic characteristics and antiretroviral exposure in pregnant women.Results A total of 358 children born to 315 women were enrolled between 2006-2012, 262 children from the National Institute for Infectious Diseases "Prof. Dr. Matei Balș" Bucharest (NIID) and 96 children from the Clinical Infectious Diseases Hospital Constanța (IDHC). Gender rate in newborns and mean age in mothers were similar. We recorded statistically significant differences between centers in the rate of HIV vertical transmission (16.8% vs. 6.2%, p=0.002) and prematurity (25.2 vs. 14.6%, p=0.023). The most used antiretroviral combination during pregnancy in IDHC was boosted lopinavir and fixed dose zidovudine-lamivudine (66% of cases), while in NIID a greater diversity of antiretrovirals were used. Women from IDHC were more frequently treated during pregnancy (83.3% vs. 68.6%, p=0.004). HCV coinfection and illegal drug use were associated with prematurity in the NIID cohort (p=0.037, p=0.024).Conclusion We found a higher rate of premature birth and HIV infection in NIID. In IDHC we found a higher rate of low birth weight in children and a higher rate of heavily treated women. Prematurity was associated with hepatitis C infection and illegal drug use in the NIID cohort.

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A review of reproductive health research, guidelines and related gaps for women living with HIV

Cited by 30 publications

References 50 publications

Women living with HIV still lack highly effective contraception: results from the ANRS VESPA2 study, France, 2011

Women living with HIV still lack highly effective contraception: results from the ANRS VESPA2 study, France, 2011

Caring for women living with HIV: gaps in the evidence

Birth outcome in HIV vertically-exposed children in two Romanian centers

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