A review of select minerals influencing the haematopoietic process

Oliveira, Dalila Cunha de; Nogueira‐Pedro, Amanda; Santos, Ed Wilson; Hastreiter, Araceli Aparecida; Silva, Graziela Batista; Borelli, Primavera; Fock, Ricardo Ambrósio

doi:10.1017/s0954422418000112

Cited by 21 publications

(16 citation statements)

References 145 publications

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“…Nevertheless, few studies investigated the role of intra- and extracellular Mg 2+ concentrations in megakaryocytes in the bone marrow. Mg 2+ deficiency may promote defects in platelet biogenesis due to changes in the cytoskeleton, promoting changes in platelet function [ 178 ]. In an experimental model, dietary Mg 2+ deficiency impaired megakaryocytes from bone marrow, resulting in a decrease in the number and larger shape than the cells of the control animals [ 56 ].…”

Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue.

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Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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“…While these bacteria might be vulnerable to ROS, they have the ability to scavenge H 2 O 2 , thus limiting hydroxyl production and surviving copper-induced stresses [21]. Correspondingly, mammalian tissue may suffer damage from excess copper exposure, while for copper deficient individuals, differentiation of blood cells may be hindered and patient health could suffer as a result [22]. For this reason, the World Health Organization has stated a copper limit of 2–3 mg/day [23].…”

Section: Introductionmentioning

confidence: 99%

Effect of Copper Ion Concentration on Bacteria and Cells

2019

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In the oral cavity, dental implants—most often made of commercially pure titanium—come in contact with bacteria, and antibacterial management has been researched extensively to improve patient care. With antibiotic resistance becoming increasingly prevalent, this has resulted in copper being investigated as an antibacterial element in alloys. In this study, the objective was to investigate the copper ion concentrations at which cyto-toxicity is avoided while bacterial inhibition is ensured, by comparing Cu ion effects on selected eukaryotes and prokaryotes. To determine relevant copper ion concentrations, ion release rates from copper and a 10 wt. % Cu Ti-alloy were investigated. Survival studies were performed on MC3T3 cells and Staphylococcus epidermidis bacteria, after exposure to Cu ions concentrations ranging from 9 × 10−3 to 9 × 10−12 g/mL. Cell survival increased from <10% to >90% after 24 h of exposure, by reducing Cu concentrations from 9 × 10−5 to 9 × 10−6 g/mL. Survival of bacteria also increased in the same range of Cu concentrations. The maximum bacteria growth was found at 9 × 10−7 g/mL, probably due to stress response. In conclusion, the minimum inhibitory concentrations of Cu ions for these prokaryotes and eukaryotes were found in the range from 9 × 10−5 to 9 × 10−6 g/mL. Interestingly, the Cu ion concentration correlating to the release rate of the 10 wt. % Cu alloy (9 × 10−8 g/mL) did not kill the bacteria, although this alloy has previously been found to be antibacterial. Further studies should investigate in depth the bacteria-killing mechanism of copper.

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“…These studies suggest that, in rats or mice, an appropriate amount of zinc is needed for erythropoiesis. Although select minerals influencing the hematopoietic process have been reviewed recently [ 42 ], no direct animal studies have shown that zinc induces RBC formation in rats.…”

Section: Introductionmentioning

confidence: 99%

Zinc Supplementation Stimulates Red Blood Cell Formation in Rats

Chen¹,

Feng

Jeng

2018

IJMS

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In rats, mice, and humans, it is known that zinc deficiency may be related to anemia, and zinc supplementation influences hemoglobin production. Our previous studies indicate that in fish, zinc supplementation stimulates red blood cell (RBC) formation (erythropoiesis). However, it is not clear whether the mechanism of zinc-induced erythropoiesis stimulation in fish also occurs in rats. We induced anemia in rats using phenylhydrazine (PHZ) and injected either saline or ZnSO4 solution. We found that an appropriate amount of zinc stimulated erythropoiesis in the PHZ-induced anemic rats. The effects of ZnSO4 injection were dose-dependent. When the concentration of ZnSO4 was higher than 2.8 mg zinc/kg body weight, the RBC level of the anemic rats increased from 60 ± 7% to 88 ± 10% that of the normal rats in two days. Rat bone marrow cells with or without ZnCl2 supplementation were cultured in suspension in vitro. In the cell culture when the zinc concentration was at 0.3 mM, a 1.6-fold proliferation of nascent immature reticulocytes (new RBCs) was observed after one day. In the rat blood, zinc was combined with serum transferrin to induce erythropoiesis. The stimulation of RBC formation by zinc appears to be common among different animals.

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A review of select minerals influencing the haematopoietic process

Cited by 21 publications

References 145 publications

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Effect of Copper Ion Concentration on Bacteria and Cells

Zinc Supplementation Stimulates Red Blood Cell Formation in Rats

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