2005
DOI: 10.1002/chin.200508262
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A Review of Solid‐Phase Organic Synthesis on SynPhase Lanterns and SynPhase Crowns

Abstract: For Abstract see ChemInform Abstract in Full Text.

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Cited by 3 publications
(4 citation statements)
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“…158 In the pair phase, different macrocyclic structures of a linear intermediate were subjected to different reactions, including RuAAC, to generate a total of 48 macrocyclic scaffolds ranging from 8-to 14-membered ring systems. These 48 scaffolds were then finally further diversified on solid-phase by utilizing SynPhase Lantern technology 159 to produce a library of more than 30 000 compounds. The RuAAC macrocyclization reactions were reliable and were routinely performed on 5-10 g scale in 50-80% yield.…”
Section: Scheme 35mentioning
confidence: 99%
“…158 In the pair phase, different macrocyclic structures of a linear intermediate were subjected to different reactions, including RuAAC, to generate a total of 48 macrocyclic scaffolds ranging from 8-to 14-membered ring systems. These 48 scaffolds were then finally further diversified on solid-phase by utilizing SynPhase Lantern technology 159 to produce a library of more than 30 000 compounds. The RuAAC macrocyclization reactions were reliable and were routinely performed on 5-10 g scale in 50-80% yield.…”
Section: Scheme 35mentioning
confidence: 99%
“…We identified two regions of the dominant epitope (P28mer sequence) by peptide microarray as important for PLA2R autoantibody binding, specifically, the VIQSES and SVLTLENC regions. An in-depth analysis of the epitope substitution scans of both peptides highlighted the importance of the conserved amino acid positions 1 V, 2 I, and 5 E in the N-terminal linear stretch VIQSES, as well as amino acids position 13 S, 14 V, and 15 L in the C-terminal stretch SVLTLENC. We found these two linear peptides could inhibit PLA2R autoantibody binding to PLA2R in solution at similar levels to the P28mer epitope sequence.…”
Section: Discussionmentioning
confidence: 99%
“…However, there are issues with targeting the CysR epitope, which need to be overcome. The length of the peptide makes manufacturing difficult, potentially expensive, time consuming, and difficult to scale up production by solid-phase peptide synthesis (14). The presence of a disulphide bond within the peptide can also impact its stability.…”
mentioning
confidence: 99%
“…Geysen et al ( 1984 ) described an alternative SMPS strategy known as multipin method based on multiple peptides synthesis on individual polyethylene sticks mounted on a block in an array that fit into the wells of enzyme-linked immunosorbent assay (ELISA) plates (8 rows and 12 columns) thus simplifying the subsequent screening by ELISA (Geysen et al 1987 ; Tribbick 2002 ). Afterwards, polyethylene sticks were replaced by SynPhase Lanterns whose shape has been designed to maximize loading surface area (Ede 2002 ; Parson et al 2003 ).…”
Section: Peptide Libraries Synthesismentioning
confidence: 99%