2015
DOI: 10.1007/s00701-015-2582-6
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A review of spontaneous intracranial extradural hematoma in sickle-cell disease

Abstract: Sickle-cell disease is common among patients of Afro-Caribbean origin. Though it can precipitate neurological conditions, it only rarely causes neurosurgical problems, with very few reported cases. We describe the case of a 7-year-old girl with a background of sickle-cell disease (SCD) brought into an acute neurosurgical unit in extremis, signs of a raised ICP, and with no history of recent trauma. Following further investigations, an acute drop in the hemoglobin and hematocrit levels were noted, with the caus… Show more

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Cited by 23 publications
(33 citation statements)
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“…Although there are reports of spontaneous SGHs in the literature, to our knowledge none of them presented with isolated spontaneous SGHs as in this case. One case was similar to our case but with EDH on one side of the head and an SGH on the other side [10]. This finding was attributed to a skull infarction, which could also have been the reason for the hematoma in our case.…”
Section: Discussionsupporting
confidence: 84%
“…Although there are reports of spontaneous SGHs in the literature, to our knowledge none of them presented with isolated spontaneous SGHs as in this case. One case was similar to our case but with EDH on one side of the head and an SGH on the other side [10]. This finding was attributed to a skull infarction, which could also have been the reason for the hematoma in our case.…”
Section: Discussionsupporting
confidence: 84%
“…There are 22 published case reports of EDHs in SCD. Hettige et al in 2015 published a thorough literature review that compares and contrasts the clinical and radiological findings in these 22 cases and briefly outlines the hypothesised mechanisms that underlie the formation of EDH in SCD 19. However, an in-depth summary of these mechanisms is lacking.…”
Section: Discussionmentioning
confidence: 99%
“…However, a minority of patients may require urgent neurosurgical intervention if there are signs of raised or worsening intracranial pressure 4. Our case responded well to conservative management with intravenous fluids, oxygen and opioid analgesics, and repeat neuroimaging after 48 hours did not show any enhancement of the EDHs.…”
Section: Answer To Questionmentioning
confidence: 60%