A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology

Babin, Étienne; Cano-Sancho, Germán; Vigneau, Évelyne; Antignac, Jean-Philippe

doi:10.1016/j.envpol.2023.121741

Cited by 4 publications

(1 citation statement)

References 108 publications

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“…NAMs are developed to identify a toxicologically relevant response at different biological levels (molecular, cellular, organ, organism) provoked by a chemical exposure (Vinken et al, 2017). NAMs include in cellulo, in vitro and in chemico screening, computational methods as well as high throughput multi-omics and exposomics (Babin et al, 2023;Maitre et al, 2023) to mention but a few methodologies. Recently, a study explored the progress in this 'next-generation' of risk assessment methodologies, and highlighted a low, but still growing evolution and use of NAMs in toxicity testing and risk assessment (Krewski et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Jaylet,

Coustillet,

Smith

et al. 2024

Front. Toxicol.

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Introduction: The Adverse Outcome Pathway (AOP) concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database, which is supported by the OECD. Here, we present a study that aims at identifying well-defined biological areas, as well as gaps within the AOP-Wiki for future research needs. It does not intend to provide a systematic and comprehensive summary of the available literature on AOPs but summarizes and maps biological knowledge and diseases represented by the already developed AOPs (with OECD endorsed status or under validation).Methods: Knowledge from the AOP-Wiki database were extracted and prepared for analysis using a multi-step procedure. An automatic mapping of the existing information on AOPs (i.e., genes/proteins and diseases) was performed using bioinformatics tools (i.e., overrepresentation analysis using Gene Ontology and DisGeNET), allowing both the classification of AOPs and the development of AOP networks (AOPN).Results: AOPs related to diseases of the genitourinary system, neoplasms and developmental anomalies are the most frequently investigated on the AOP-Wiki. An evaluation of the three priority cases (i.e., immunotoxicity and non-genotoxic carcinogenesis, endocrine and metabolic disruption, and developmental and adult neurotoxicity) of the EU-funded PARC project (Partnership for the Risk Assessment of Chemicals) are presented. These were used to highlight under- and over-represented adverse outcomes and to identify and prioritize gaps for further research.Discussion: These results contribute to a more comprehensive understanding of the adverse effects associated with the molecular events in AOPs, and aid in refining risk assessment for stressors and mitigation strategies. Moreover, the FAIRness (i.e., data which meets principles of findability, accessibility, interoperability, and reusability (FAIR)) of the AOPs appears to be an important consideration for further development.

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Section: Introductionmentioning

confidence: 99%

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Jaylet,

Coustillet,

Smith

et al. 2024

Front. Toxicol.

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Research hotspots and evolution trends of food safety risk assessment techniques and methods

Wang,

2024

eFood

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Food safety incidents frequently occur in China and other countries. Food safety risk management has evolved from harm‐based to risk‐based approaches to control risks more scientifically and effectively. Risk assessment is at the core of risk control and provides a scientific basis for the development of risk management measures. Therefore, analyzing the research status and development trends of food safety risk assessment technologies and methods is important for improving food safety risk assessment and risk management. In this study, CiteSpace software was used to analyze a knowledge graph of popular research topics in the field of food safety risk assessment over the past 14 years, identify research keywords, and provide centrality statistics. Food safety risk assessments primarily focus on in vitro high‐throughput testing, computational toxicology, predictive microbiology, mechanistic research, and other technical methods. In the future, international coordination, cooperation, and cross‐integration of relevant disciplines should be strengthened, and research on and application of innovative technologies for food safety risk assessment should be promoted. Research on food safety risk assessment technologies and methods is in an active development stage and has good prospects for further exploration and application.

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Opportunities offered by latent-based multiblock strategies to integrate biomarkers of chemical exposure and biomarkers of effect in environmental health studies

Babin,

Vigneau,

Antignac

et al. 2024

Chemosphere

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A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology

Cited by 4 publications

References 108 publications

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Research hotspots and evolution trends of food safety risk assessment techniques and methods

Opportunities offered by latent-based multiblock strategies to integrate biomarkers of chemical exposure and biomarkers of effect in environmental health studies

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