Investigating water-land-climate interactions is critical for urban development and watershed management. This study examined this nexus by elasticity and statistical approaches through the lens of three watersheds: The Yukon, Mekong and Murray. Here, this study reports the fundamental characteristics, explanations and ecological and management implications of terrestrial determinant influence on the response of water quality to climate drivers. The stability of the response, measured by climate elasticity of water quality (CEWQ), is highly dependent on terrestrial determinants, with strong impacts from anthropogenic biomes and low impacts from surficial geology. Compared to temperature elasticity, precipitation elasticity of water quality is more unstable due to its possible linkages with many terrestrial determinants. Correlation and linear models were developed for the interaction system, which uncovered many interesting scenarios. The results implied that watersheds with a higher ratio of rangeland biomes have a lower risk of instability as compared to watersheds with a higher proportion of dense settlement, cropland and forested biomes. This study discusses some of the most essential pathways where instability might adversely affect CEWQ parameters and recommends suggestions for policy makers to alleviate the instability impacts to bring sustainability to the water environment.