eCM 2017
DOI: 10.22203/ecm.v034a17
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A review of the application of reinforced hydrogels and silk as biomaterials for intervertebral disc repair

Abstract: The degeneration of the intervertebral disc (IVD) within the spinal column represents a major pain source for many patients. Biological restoration or repair of the IVD using "compressive-force-resistant" and at the same time "cytocompatible" materials would be desirable over current purely mechanical solutions, such as spinal fusion or IVD implants. This review provides an overview of recent research on the repair of the inner (nucleus pulposus = NP) and the outer (annulus fibrous = AF) parts of the IVD tissu… Show more

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Cited by 31 publications
(25 citation statements)
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“…In this manuscript, we focus on repairing the AF after disc herniation with the combination of specifically adjusted biomaterials for IVD repair. This form of treatment is gaining in importance and is increasingly investigated [ 2 ]. Recently, AF injury was induced in vivo in a sheep model by injection of riboflavin cross-linked high-density collagen gel ability to mitigate IVD degeneration after induced AF injury [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
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“…In this manuscript, we focus on repairing the AF after disc herniation with the combination of specifically adjusted biomaterials for IVD repair. This form of treatment is gaining in importance and is increasingly investigated [ 2 ]. Recently, AF injury was induced in vivo in a sheep model by injection of riboflavin cross-linked high-density collagen gel ability to mitigate IVD degeneration after induced AF injury [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…One of the materials particularly suggested for AF repair is a genipin-enhanced fibrin hydrogel, which has become promising not only for IVD but also for cartilage repair [ 4 ] as it can fix an AF injury such that it can withstand applied compressional and torsional loads [ 2 , 5 ]. Fibrin hydrogels have already been widely used for years as a sealant for the AF, the outer tissue within the IVD, during surgeries but are too fragile in this form to withstand physiological loading in the spine.…”
Section: Introductionmentioning
confidence: 99%
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“…Intervertebral DD progresses over time and is hard to stop or reverse, as treatments that successfully interfere with progression are still not available. However, recent in vitro and in vivo studies on regenerative therapies for DD show some promising results, and more insight in the factors that encourage the progression of DD may therefore provide valuable stepping stones towards personalized treatments, as we then know which patients should be targeted with these therapies. The aim of this systematic review was to identify the prognostic factors associated with progression of DD.…”
Section: Discussionmentioning
confidence: 99%
“…The films were pasted on the glass slides using the cyanoacrylate adhesive. 13 Moreover, a quantity of one mL was removed at 5, 15, 30, 60, 90, 120, 180, 240, 300, 360, and 480 minutes intervals, exchanged by the fresh phosphate buffered saline, with a pH of 6.8 and analyzed spectrophotometrically at 207 nm. Finally, the concentration was computed using the calibration curve of ISDN in this medium.…”
Section: In Vitro Release Studymentioning
confidence: 99%