A review of the bioactive ingredients of berries and their applications in curing diseases

Bilawal, Akhunzada; Ishfaq, Muhammad; Gantumur, Munkh-Amgalan; Qayum, Abdul; Shi, Run; Fazilani, Saqib Ali; Anwar, Asif; Jiang, Zhanmei; Hou, Juncai

doi:10.1016/j.fbio.2021.101407

Cited by 33 publications

(12 citation statements)

References 143 publications

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“…Therefore, it suffices that the nutritional quality of berries as well as associated health benefits may be related to the presence of these nutritive and non-nutritive compounds (Foito et al, 2018). An extensive body of work has been undertaken to assay the composition of some of the widely consumed berries to characterize phytochemicals possessing bioactive properties (Bilawal et al, 2021;Gündes ¸li et al, 2019;Schulz & Chim, 2019). Thus, the phytochemical and nutritional composition of berries are reviewed along with their associated health benefits in the following sections.…”

Section: Nutrient Composition Of Berriesmentioning

confidence: 99%

Functional Foods and Their Implications for Health Promotion

Hasan,

Arief,

Sangadji

2023

Journal of Nutrition Education and Behavior

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Section: Nutrient Composition Of Berriesmentioning

confidence: 99%

Functional Foods and Their Implications for Health Promotion

Hasan,

Arief,

Sangadji

2023

Journal of Nutrition Education and Behavior

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“…They are considered one of the top five healthiest fruits by the Food and Agriculture Organization (FAO) [ 5 ]. Consumers often regard blueberries as “superfoods”, “functional foods”, “nutrient powerhouses”, and “natural health packages” due to their rich content of micronutrients, polyphenols [ 6 ], and anthocyanins [ 7 ], all of which significantly contribute to human health. Blueberries are known to be rich in bioactive compounds that offer numerous health benefits, including antioxidant, anti-inflammatory, antiseptic, antiproliferative, antiaging, antibacterial, antidiabetic, astringent, and neuro-, cardio-, vision, and kidney protection properties [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antioxidant Activities, Antidepressant Effect, and Lipid Peroxidation of Peruvian Blueberry: Molecular Docking Studies on Targets Involved in Oxidative Stress and Depression

Quispe-Díaz,

Ybañez-Julca,

Pino-Ríos

et al. 2024

Plants

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Blueberries (Vaccinium corymbosum L.) are cultivated worldwide and are among the best dietary sources of bioactive compounds with beneficial health effects. This study aimed to investigate the components of Peruvian blueberry using high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC–ESI–QTOF–MS/MS), identifying 11 compounds. Furthermore, we assessed in vitro the antioxidant activity and in vivo the antidepressant effect using a rat model and protective effect on lipid peroxidation (in the serum, brain, liver, and stomach). We also conducted molecular docking simulations with proteins involved in oxidative stress and depression for the identified compounds. Antioxidant activity was assessed by measuring total phenolic and flavonoid contents, as well as using 1,1-diphenyl-2-picrylhydrazin (DPPH), 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS•+), and ferric-reducing antioxidant power (FRAP) assays. Peruvian blueberries demonstrated higher antioxidant activity than Vaccinium corymbosum fruits from Chile, Brazil, the United States, Turkey, Portugal, and China. The results showed that oral administration of Peruvian blueberries (10 and 20 mg/kg) for 28 days significantly (p < 0.001) increased swimming and reduced immobility in the forced swimming test (FST). Additionally, at doses of 40 and 80 mg/kg, oxidative stress was reduced in vivo (p < 0.001) by decreasing lipid peroxidation in brain, liver, stomach, and serum. Molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions were performed. In the molecular docking studies, quercitrin and 3,5-di-O-caffeoylquinic acid showed the best docking scores for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, superoxide dismutase, and xanthine oxidase; while 3,5-dicaffeoylquinic acid methyl ester and caffeoyl coumaroylquinic acid had the best docking scores for monoamine oxidase and serotonin receptor 5-HT2. In summary, our results suggest that the antidepressant and protective effects against lipid peroxidation might be related to the antioxidant activity of Peruvian Vaccinium corymbosum L.

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“…As far as we know, oxidative stress leads to various diseases ( Gao et al., 2019 ). The health effects of raspberry, including its seeds, can prevent cancer by inhibiting cell proliferation, inducing autophagy, and inducing apoptosis ( Bilawal et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Widely targeted metabolome profiling of different plateau raspberries and berry parts provides innovative insight into their antioxidant activities

Ren

Wang

et al. 2023

Front. Plant Sci.

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Raspberries are highly nutritious and have powerful antioxidant properties, making them functional berries with positive effects on physiological functioning. However, there is limited information available on the diversity and variability of metabolites in raspberry and its parts, especially in plateau raspberries. To address this, commercial raspberries and their pulp and seeds from two plateaus in China were subjected to LC-MS/MS-based metabolomics analysis and evaluated for antioxidant activity using four assays. A metabolite-metabolite correlation network was established based on antioxidant activity and correlation analysis. The results showed that 1661 metabolites were identified and classified into 12 categories, with significant variations in composition between the whole berry and its parts from different plateaus. Flavonoids, amino acids and their derivatives, and phenolic acids were found to be up-regulated in Qinghai’s raspberry compared to Yunnan’s raspberry. The main differently regulated pathways were related to flavonoid, amino acid, and anthocyanin biosynthesis. The antioxidant activity of Qinghai’s raspberry was stronger than Yunnan’s raspberry, and the order of antioxidant capacity was seed > pulp > berry. The highest FRAP (420.31 µM TE/g DW) values was found in the seed of Qinghai’s raspberry. Overall, these findings suggest that the environment in which the berries grow can affect their chemical composition, and comprehensive exploitation and cultivation of whole raspberry and its parts from different plateaus can lead to new opportunities for phytochemical compositions and antioxidant activity.

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A review of the bioactive ingredients of berries and their applications in curing diseases

Cited by 33 publications

References 143 publications

Functional Foods and Their Implications for Health Promotion

Functional Foods and Their Implications for Health Promotion

Chemical Composition, Antioxidant Activities, Antidepressant Effect, and Lipid Peroxidation of Peruvian Blueberry: Molecular Docking Studies on Targets Involved in Oxidative Stress and Depression

Widely targeted metabolome profiling of different plateau raspberries and berry parts provides innovative insight into their antioxidant activities

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