A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen

Li, Huayao; Gao, Chundi; Liu, Cun; Liu, Lijuan; Zhuang, Jing; Yang, Jing; Zhou, Chao; Feng, Fubin; Wu, Jibiao

doi:10.1016/j.biopha.2021.111332

Cited by 70 publications

(48 citation statements)

References 69 publications

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“…Cryptotanshinone is a quinoid diterpenoid isolated from the roots of the plant Salvia miltiorrhiza (family Lamiaceae ). It is a compound with proven multidirectional activities, including anti-inflammatory, antioxidant, and anticancer properties against breast, lung, and liver cancer [ 60 ]. Cryptotanshinone was also proven to exhibit anticancer effects by inducing apoptosis, modulating cell proliferation, and inhibiting ovarian cell metastasis.…”

Section: Synergism Of Biologically Active Compounds With Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Synergism Of Biologically Active Compounds With Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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“…Thus, more research is needed to find new, safe and effective therapeutic drugs with few side effects ( Williams et al, 2012 ). Cryptotanshinone (CPT), a major lipophilic compound extracted from Salvia miltiorrhiza demonstrated various pharmacological effects, including anti-tumor ( Li H. et al, 2021 ), anti-inflammatory ( Tang et al, 2018 ), anti-bacterial, anti-proliferation ( Ashrafizadeh et al, 2021 ), anti-androgen ( Xu et al, 2012 ), pulmonary fibrosis protection, cardio protection, anti-metabolic disorders, anti-angiogenic ( Maione et al, 2018 ) and liver protection ( Nagappan et al, 2020 ). In addition, it is often used to treat multiple chronic diseases, including angiocardiopathy, hyperlipidemia, acne vulgaris and chronic renal failure, with few side effects ( Rahman et al, 2016 ; Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention

et al. 2021

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The label-free methods of proteomic combined with metabolomics were applied to explore the mechanisms of Cryptotanshinone (CPT) intervention in rats with acne. The model group consisted of rats given oleic acid (MC), then treated with CPT, while control groups did not receive treatment. The skin samples were significantly different between control, model and CPT-treated groups in hierarchical clustering dendrogram. Obvious separations of the skin metabolic profiles from the three groups were found through PCA scoring. In total, 231 and 189 differentially expressed proteins (DEPs) were identified in MC and CPT groups, respectively. By the KEGG analysis, five protein and metabolite pathways were found to be significantly altered. These played important roles in response to oleic acid-induced acne and drug treatment. CPT could negatively regulate glycolysis/gluconeogenesis and histidine metabolisms to decrease keratinocyte differentiation and improve excessive keratinization and cellular barrier function. CPT could down-regulate the IL-17 signaling pathway and regulate the acne-driven immune response of sebum cells. The biosynthesis of unsaturated fatty acids metabolism, glycerophospholipid metabolism and linoleic acid pathways could significantly alter sebum production and control sebaceous gland secretion after CPT treatment. The gap junction was up-regulated after CPT treatment and the skin barrier turned back to normal. Krt 14, Krt 16 and Krt 17 were significantly down-regulated, decreasing keratinization, while inflammatory cell infiltration was improved by down-regulation of Msn, up-regulation of linoleic acid and estrogen pathways after CPT treatment. These results propose action mechanisms for the use of CPT in acne, as a safe and potential new drug.

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“…TLR4, as an upstream target of NF‐κB, can be used through MyD88 and other related factors to regulate the course of inflammation (Liang, Yang, Liu, Sun, & Wang, 2018). There is growing evidence that TLR2 and TLR4 signaling not only activate the ASK1/p38 MAPK/NF‐KB signaling pathway but also stimulate the ERK/JNK and PI3K/Akt pathways in a MyD88‐independent manner (H. Li et al, 2021).…”

Section: Antiliver Fibrotic Property Of Quercetinmentioning

confidence: 99%

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

Zhao

Wang

Deng

et al. 2021

Phytotherapy Research

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Quercetin is the major representative of the flavonoid subgroup of flavones, with good pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty hepatitis, liver fibrosis, and liver cancer. It can significantly influence the development of liver diseases via multiple targets and multiple pathways via antifat accumulation, anti‐inflammatory, and antioxidant activity, as well as the inhibition of cellular apoptosis and proliferation. Despite extensive research on understanding the mechanism of quercetin in the treatment of liver diseases, there are still no targeted therapies available. Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF‐κB/TLR/NLRP3, reduced PI3K/Nrf2‐mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases. In addition, quercetin showed different mechanisms of action at different stages of liver diseases, including the regulation of PPAR, UCP, and PLIN2‐related factors via brown fat activation in liver steatosis. The compound inhibited stromal ECM deposition at the liver fibrosis stage, affecting TGF1β, endoplasmic reticulum stress (ERs), and apoptosis. While at the final liver cancer stage, inhibiting cancer cell proliferation and spread via the hTERT, MEK1/ERK1/2, Notch, and Wnt/β‐catenin‐related signaling pathways. In conclusion, quercetin is an effective liver protectant. We hope to explore the pathogenesis of quercetin in different stages of liver diseases through the review, so as to provide more accurate targets and theoretical basis for further research of quercetin in the treatment of liver diseases.

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A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen

Cited by 70 publications

References 69 publications

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

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