A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

Sowndhararajan, Kandhasamy; Deepa, Ponnuvel; Kim, Min-Ju; Park, Se Jin

doi:10.3390/scipharm85030033

Cited by 47 publications

(35 citation statements)

References 52 publications

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“…Sowndhararajan et al reported that there are differences in major components depending on the plant part, yield, and extraction method in essential oil of various species of Angelica [ 32 ]. Therefore, to clarify the major components and biologically active components of the AGN extract, the AGN extract was divided into eight fractions.…”

Section: Resultsmentioning

confidence: 99%

Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

Jeon

Shin

Lee

et al. 2018

BioMed Research International

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Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system. In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells. Of the 420 plant extracts screened, the extract of Angelica gigas Nakai (AGN) was the most effective in reducing cell viability of HeLa cells. Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract. Treatment of the AGN extract increased expression of PKR as well as ATF4 and CHOP, the unfolded protein response genes. In addition, cotreatment of doxorubicin and the AGN extract significantly increased doxorubicin-induced apoptosis in HeLa cells. Decursin and decursinol angelate, which were known to have anticancer effects, were the main components of the AGN extract. These results suggest that the extract of AGN containing, decursin and decursinol angelate, increases doxorubicin susceptibility.

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Section: Resultsmentioning

confidence: 99%

Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

Jeon

Shin

Lee

et al. 2018

BioMed Research International

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“…Microbial infestation is a major cause of food spoilage. It has been reported that AEO has effective and broad-spectrum antibacterial activity, which could be related to ligustilide, one of the main compounds of AEO [35]. The antibacterial activity of gelatin/AEO nanofibers tested by semi-quantitative shake flask method is presented in Figure 7.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Angelica Essential Oil Loaded Electrospun Gelatin Nanofibers for Active Food Packaging Application

et al. 2020

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The development of food packaging possessing bioactivities which could extend the shelf life of food has gained increased interest in recent years. In this study, gelatin nanofibers with encapsulated angelica essential oil (AEO) were fabricated via electrospinning. The morphology of gelatin/AEO nanofibers was examined by scanning electron microscopy (SEM) and the addition of AEO resulted in the increase of fiber diameter. The proton nuclear magnetic resonance (1H-NMR) spectra were measured to confirm the presence of AEO in nanofibers. The hydrophobic property of gelatin nanofibers was also found to be improved with the addition of AEO. The nanofibers incorporated with AEO showed significant antioxidant activity and inhibitory effect against both Gram-negative and Gram-positive bacteria in a concentration dependent manner. Furthermore, the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay demonstrated that the developed gelatin/AEO nanofibers revealed no cytotoxicity effect. Thus, gelatin nanofibers incorporated with AEO can be used as potential food packaging.

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“…Essential oils are able to counteract free radicals and anti-inflammatory agents against oxidative explosions [23]. The content of terpene compounds in essential oils of canarium tree resin that is β-phellandrene, α-phellandrene, γ-terpinene and ρ-cymene are reported to provide anti-inflammatory properties by inhibiting migration and decreasing the production of inflammatory mediators, including protease and proinflammatory enzymes such as COX-1 and COX2 [24]. αphellandrene significantly decreases mast cell degranulation in regulating the inflammatory response.…”

Section: Effects Of Resin Essential Oils Of Canarium Tree On Proteasementioning

confidence: 99%

Influence of Treating Essential Oils of Canarium Tree Resin on The Level Malondialdehyde (MDA), Protease Activity, Bronchi Histopathology Description and Expression of Tumor Necrosis Alpha Factor (TNF-α) on Asthma Rats (Rattus norvegicus)

Mbabho

Aulanni’am

Srihardyastutie

2018

J. Pure App. Chem. Res.

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Essential oils of canarium tree resin (Canarium indicum L) have anti-inflammatory and antioxidant activity. The purpose of this study was to investigate the potential of essential oils of canarium tree resin on the expression of TNF-α, changes in bronchial epithelial cell features, MDA levels and protease activity on asthma rats. This study used four groups of rats, the negative control group, asthma group, therapy group dose of 25 mg/kg body weight, 50 mg/kg body weight and 100 mg/kg body weight. The ashtma rats were prepared by OVA and LPS. TNF-α expression was calculated using Walter calculation, MDA level was measured using Thiobarbituric Acid (TBA), measurement of protease activity was done by spectrophotometric method, and all data analyzed by ANOVA. Histopathologic observation of bronchi was done using Olympus BX51 microscope. The results showed that the therapy of essential oils of canarium tree resin of 25 mg/kg body weight, 50 mg/kg body weight and 100 mg/kg body weight significantly (p<0.05) decreased, MDA up to 54%, protease activity up to 46%, improved bronchial epithelium and TNF-α expression up to 67%. This study proves that essential oils of canarium tree resin can be effectively used as therapy on asthma rats.

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A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

Cited by 47 publications

References 52 publications

Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

Angelica Essential Oil Loaded Electrospun Gelatin Nanofibers for Active Food Packaging Application

Influence of Treating Essential Oils of Canarium Tree Resin on The Level Malondialdehyde (MDA), Protease Activity, Bronchi Histopathology Description and Expression of Tumor Necrosis Alpha Factor (TNF-α) on Asthma Rats (Rattus norvegicus)

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