A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

Komi, Daniel Elieh Ali; Khomtchouk, Kelly; Maria, Peter L. Santa

doi:10.1007/s12016-019-08729-w

Cited by 275 publications

(233 citation statements)

References 111 publications

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“…This may be the result of IL‐1β interaction with another cytokines, for example, IL‐6. IL‐6 may act either as pro‐ or anti‐inflammatory cytokine (Komi, Khomtchouk, & Santa Maria, ). It may activate inflammatory processes but also take a part in inhibition of TNF‐α and IL‐1 production (Scheller, Chalaris, Schmidt‐Arras, & Rose‐John, ; Zong et al, ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Konop

Czuwara

Kłodzińska

et al. 2020

J Tissue Eng Regen Med

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Keratin is a cytoskeletal scaffolding protein essential for wound healing and tissue recovery. The aim of the study was to evaluate the potential role of insoluble fur keratin‐derived powder containing silver nanoparticles (FKDP‐AgNP) in the allogenic full‐thickness surgical skin wound model in diabetic mice. The scanning electron microscopy image evidenced that the keratin surface is covered by a single layer of silver nanoparticles. Data obtained from dynamic light scattering and micellar electrokinetic chromatography showed three fractions of silver nanoparticles with an average diameter of 130, 22.5, and 5 nm. Microbiologic results revealed that the designed insoluble FKDP‐AgNP dressing to some extent inhibit the growth of Escherichia coli and Staphylococcus aureus. In vitro assays showed that the FKDP‐AgNP dressing did not inhibit fibroblast growth or induce hemolysis. In vivo studies using a diabetic mice model confirmed biocompatible properties of the insoluble keratin dressings. FKDP‐AgNP significantly accelerated wound closure and epithelization at Days 5 and 8 (p < .05) when compared with controls. Histological examination of the inflammatory response documented that FKDP‐AgNP‐treated wounds contained predominantly macrophages, whereas their untreated variants showed mixed cell infiltrates rich in neutrophils. Wound inflammatory response based on macrophages favors tissue remodeling and healing. In conclusion, the investigated FKDP‐AgNP dressing consisting of an insoluble fraction of keratin, which is biocompatible, significantly accelerated wound healing in a diabetic mouse model.

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Section: Discussionmentioning

confidence: 99%

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Konop

Czuwara

Kłodzińska

et al. 2020

J Tissue Eng Regen Med

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“…[44] Interestingly, the HF contains mast cell precursors in mice, [45] which can differentiate into mature mast cells under appropriate conditions and contribute to wound healing in the skin. [46] Mast cells are also associated with HFs in human skin, [47] and substance P produced by mast cells may contribute to HF regression by upregulating nerve growth factor (NGF) and its receptor p75NTR on HF ORS keratinocytes. [48] Cellular debris (apoptotic keratinocytes and redundant extracellular matrix, ECM) from the regressing HF are cleared by macrophages [49] and possibly neighbouring keratinocytes, which appear to take on phagocytic abilities.…”

Section: Catagenmentioning

confidence: 99%

Immune cell regulation of the hair cycle

Wang

2020

Experimental Dermatology

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The ability to manipulate the mammalian hair cycle will lead to novel therapies and strategies to combat all forms of alopecia. Thus, in addition to the epithelial‐mesenchymal interactions in the hair follicle, niche and microenvironmental signals that accompany the phases of growth, regression and rest need to be scrutinized. Immune cells are well described in skin homeostasis and wound healing and have recently been shown to play an important role in the mammalian hair cycle. In this review, we will summarize our current knowledge of the role of immune cells in hair cycle control and discuss their relevance to human hair cycling disorders. Increased attention to this aspect of the hair cycle will provide new avenues to manipulate hair regeneration in humans and provide better insight into developing better ex vivo models of hair growth.

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“…Induction of myofibroblast apoptosis usually occurs following the completion of scarring and contributes to the control of the degree of fibrosis. However, myofibroblasts continue to produce excessive amounts of matrix components during aberrant wound healing processes [43]. The number of infiltrating MCs is increased in IPF lungs than in normal healthy lungs and infiltrating MC numbers correlates with the degree of fibrosis [44].…”

Section: Distribution Of Mcs and Their Function In Idiopathic Pulmonamentioning

confidence: 99%

“…The number of infiltrating MCs is increased in IPF lungs than in normal healthy lungs and infiltrating MC numbers correlates with the degree of fibrosis [44]. Mechanistically, this may involve MC-derived chymase which can induce fibroblast proliferation [43,45]. In fibrotic lung diseases, the interplay between MCs and fibroblasts contributes to the formation of a profibrotic milieu in which fibroblasts support MC survival and proliferation by producing SCF and in turn, MC-derived chymase activates latent TGF-β1 which mediates fibroblast to myofibroblast differentiation [46,47].…”

Section: Distribution Of Mcs and Their Function In Idiopathic Pulmonamentioning

confidence: 99%

The Role of Mast Cells in IgE-Independent Lung Diseases

Komi

Mortaz

Amani

et al. 2020

Clinic Rev Allerg Immunol

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Mast cells (MCs) are granular cells of the innate immune system which develop from CD34 + /CD117 + progenitors and play a role in orchestrating adaptive immune responses. They have a well-known role in allergic reactions following immunoglobulin (Ig)Emediated activation of the cell-surface expressed IgE high-affinity receptor (FcεRI). MCs can also respond to various other stimuli due to the expression of a variety of receptors including toll-like receptors (TLRs), immunoglobulin (IgG) receptors (FcγR), complement receptors such as C5a (CD88) expressed by skin MCs, neuropeptides receptors including nerve growth factor receptor, (NGFR), cytokines receptors such as (IL)-1R and IL-3R, and chemokines receptors including CCR-1 and CCR-3. MCs release three groups of mediators upon degranulation differentiated according to their chemical composition, storage, and time to release. These include preformed mediators (mainly histamine, tryptase, and chymase), de novo synthesized mediators such as prostaglandin (PG)D2, leukotriene (LT)B4 and LTD4, and cytokines including IL-1β, IL-3, tumor necrosis factor (TNF)α, and transforming growth factor(TGF)-β. Emerging evidence indicates a role for IgE-independent MC activation in the late-stage asthmatic response as well as in non-allergic airway diseases including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. MC infiltration/activation has been reported in some, but not all, studies of lung cancer. MC-derived TNF-α possesses tumor-suppressive activity while IL-1β supports tumor progression and metastasis. In IPF lungs, an increase in density of tryptase-and chymase-positive MCs (MCTC) and overexpression of TGF-β support the fibrosis progression. MC-derived chymase activates latent TGF-β that induces the differentiation of fibroblasts to matrix-producing myofibroblasts. In summary, increasing evidence highlights a critical role of MCs in non-allergic diseases that may indicate new approaches for therapy.

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A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

Cited by 275 publications

References 111 publications

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Immune cell regulation of the hair cycle

The Role of Mast Cells in IgE-Independent Lung Diseases

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