A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity

Sénéchal, Hélène; Visez, Nicolas; Charpin, D.; Shahali, Youcef; Peltre, Gabriel; Biolley, Jean-Philippe; Lhuissier, F.; Couderc, Rémy; Yamada, Ohri; Malrat-Domenge, Audrey; Pham‐Thi, N.; Poncet, Pascal; Sutra, Jean-Pierre

doi:10.1155/2015/940243

Cited by 171 publications

(148 citation statements)

References 255 publications

(271 reference statements)

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“…It has been shown that PM and diesel exhaust particles can carry allergens from pollen, cat, dog, and house dust mite [130]. Moreover, it has been reported that air pollution increases the allergenic potency of pollen [131][132][133]. In their model based on guinea pigs sensitized to Zinnia pollen, Chelregani et al [134] observed that pollen collected from polluted urban areas not only induced higher levels of serum IgE, but also increased eosinophil counts compared with nonpolluted pollen.…”

Section: Effect Of Air Pollutants On the Airway Epithelium And Respirmentioning

confidence: 99%

“…In their model based on guinea pigs sensitized to Zinnia pollen, Chelregani et al [134] observed that pollen collected from polluted urban areas not only induced higher levels of serum IgE, but also increased eosinophil counts compared with nonpolluted pollen. Finally, growing evidence indicates that air pollutants can increase the production of allergens and proinflammatory mediators in pollens as a result of the plant adaptive response to environmental stress [131,135]. In addition, it has been shown that pollens are a source of oxidants [136].…”

Section: Effect Of Air Pollutants On the Airway Epithelium And Respirmentioning

confidence: 99%

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Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

López-Rodríguez

Benedé

Barderas

et al. 2017

J Investig Allergol Clin Immunol

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Airway epithelium is the cellular structure with the greatest surface exposed to a plethora of environmental airborne substances, including microorganisms, respiratory viruses, air pollutants, and allergens. In addition to being a protective physical barrier at the air-liquid interface, the airway epithelium acts as an effective chemical and immunological barrier that plays a crucial role in orchestrating the immune response in the lungs, by supporting the activation, recruitment, and mobilization of immune cells. Airway epithelium dysfunction has been clearly associated with various airway inflammatory diseases, such as allergic asthma. Although it is not fully understood why a person develops respiratory allergy, a growing body of evidence shows that the nature of the host's immune response is strongly determined by the state of the airway epithelium at the time of contact with the inhaled allergen. Our review highlights the physiological state of airway epithelium as a key element in the development of allergy and, particularly, in exacerbation of asthma. We review the role of physiological oxidants as signaling molecules in lung biology and allergic diseases and examine how high exposure to air pollutants (eg, cigarette smoke and diesel particles) can contribute to the increased incidence of respiratory allergy and exacerbation of the disease. Key words: Airway epithelium. Barrier dysfunction. Respiratory allergy. Redox biology. Air pollutants. ResumenEl epitelio pulmonar constituye la barrera celular más susceptible a la acción deletérea de la multitud de agentes que se encuentran en el ambiente, incluidos los alérgenos. Además de prevenir su acceso al organismo, la barrera epitelial de las vías respiratorias juega un papel inmunomodulador crucial, regulando de forma local la acción de las células del sistema inmune subyacentes. Una disfunción epitelial, provocada tanto directa como indirectamente por la acción de los aeroalérgenos, parece ser una de las causas principales de desregulación de la homeostasis pulmonar, causando una respuesta proinflamatoria descontrolada que cada vez más autores atribuyen al origen de las reacciones alérgicas. En esta revisión se quiere destacar el papel de la barrera epitelial pulmonar como regulador de la respuesta inmune en el contexto de la alergia. Las enfermedades crónicas que afectan a las vías respiratorias, tales como el asma alérgica, muestran frecuentemente una función epitelial defectuosa, apoyando así la hipótesis antes mencionada que subyace al origen de la alergia. El impacto de otros contaminantes ambientales -como virus respiratorios, bacterias, humo del tabaco y partículas diésel-sobre la integridad epitelial, así como su influencia en la biología redox pulmonar relacionada con el desarrollo de la respuesta alérgica, también se abordarán en la presente revisión.

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Section: Effect Of Air Pollutants On the Airway Epithelium And Respirmentioning

confidence: 99%

Section: Effect Of Air Pollutants On the Airway Epithelium And Respirmentioning

confidence: 99%

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

López-Rodríguez

Benedé

Barderas

et al. 2017

J Investig Allergol Clin Immunol

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“…In addition the term "polluen" has been coined to describe the pollen/pollutant interaction and describe the make-up of pollen materials as they are often carriers of allergenic proteins and non-allergenic pollutants (45). Given the association with pollution and the fact that pollen grains are the major source of outdoor aeroallergens we explore them in particular in this review (46).…”

Section: Aeroallergensmentioning

confidence: 99%

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Ragguett

Danielle

Subramaniapillai

et al. 2017

Reviews on Environmental Health

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Objective: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. Methods: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. Results: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i.e. pollen) increase; however, not all environmental factors were explored equally. In specific, studies that were delimited to evaluating particulate matter (PM) reported a consistent association with suicidality. We also provide a brief description of putative mechanisms (e.g. inflammation and neurotransmitter dysregulation) that may mediate the association between air pollution, aeroallergens and suicidality. Conclusion:Available evidence suggests that exposure to harmful air quality may be associated with suicidality. There are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens. In addition, those with atopic sensitivity may represent a specific subgroup that is at risk.

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“…Esta situación suscita cada vez más interés, ya que las particularidades del entorno urbano, especialmente la contaminación, hace que los efectos sobre la población sean más notables (Majd et al 2004, Heinrich & Wichmann 2004, Sénéchal et al 2015 incluso cuando las concentraciones polí-nicas sean menores que en entornos rurales (Nicolau et al 2005).…”

Section: Introductionunclassified

Allergenic potential of urban green zones of the Santa María de Gracia neighborhood (Murcia, SE Spain)

Munuera-Gázquez¹,

Munuera-Giner²,

Martínez-Boscadas³

2017

An Biol

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Los espacios verdes urbanos pueden afectar negativamente a la salud de las personas alérgicas al polen. Recientemente se ha propuesto una fórmula que permite valorar el potencial alergénico de estos espacios. Tras inventariar y medir los elementos vegetales presentes en los parques, jardines y calles del barrio de Santa María de Gracia (Murcia, SE España) se han calculado los índices de alergenicidad (IUGZA) potenciales y reales para el conjunto del barrio y para sus espacios verdes más importantes. El conjunto del barrio tiene un índice de alergenicidad potencial de 0,15, con espacios que llegan a 0,25 y otros que apenas superan el 0,05. Siendo 0,3 el valor considerado como umbral suficiente para provocar alergia, puede afirmarse que el barrio es un espacio seguro de bajo riesgo desde el punto de vista de la alergia al polen.Palabras clave: Índice de alergenicidad, Espacios verdes urbanos, Polen, Alergia. Abstract Allergenic potential of urban green zones of the Santa María de Gracia neighborhood (Murcia, SE Spain)Urban green zones can negatively affect pollen allergy sufferers. A new formula has been recently proposed to estimate the potential allergenicity of urban green zones. After identify and measure the vegetal elements present in the parks, gardens and streets of Santa María de Gracia neighborhood (Murcia, SE Spain), real and potential allergenicity indexes (IUGZA) were calculated. Obtained allergenicity indexes (IUGZA) range from 0.05 to 0.25, with a mean of 0.15 for the whole neighborhood. Being 0.30 a threshold value enough to cause allergy symptoms in the population can be concluded that the neighbourhood and some of their main parks and streets are safe places for pollinosis sufferers and risk of suffering allergies is low or very low.

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A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity

Cited by 171 publications

References 255 publications

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Allergenic potential of urban green zones of the Santa María de Gracia neighborhood (Murcia, SE Spain)

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