1. The importance of taxonomy to the determination of conservation priorities and actions is widely accepted. It should be not surprising therefore that the taxonomic treatment of mammal species that have been subject to human actions in antiquity may well influence the contemporary assessment of conservation priorities at various levels.
2.As a result of early extinctions caused by humans and protohistoric and historic introductions, we suggest that the Mediterranean Basin and its islands are particularly prone to misdirection of efforts towards biodiversity conservation. 3. The two main risks associated with the failure to use an evolutionary and palaeoecological approach to conservation efforts are (i) an underestimation of the conservation importance of distinctive continental taxa vs. the apparent endemicity of island taxa; and (ii) a serious risk for native and endemic island species when anthropochorous mammals, especially ungulates, misguidedly become the focus of conservation actions, particularly inside protected areas. 4. Urgent measures, including refinement of mammal taxonomy, the exclusion of known anthropochorous taxa from conservation lists and implementation of protective legislation, are necessary to maintain the uniqueness and richness of the Mediterranean biodiversity hotspot.