A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant, William B.

doi:10.21873/anticanres.12331

Cited by 28 publications

(19 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 8000 studies have been performed to investigate the inverse correlation between vitamin D, its metabolites, and cancer [ 43 ]. Women with a higher solar UVB exposure in the Third National Health and Nutrition Examination Survey (NHANES III) showed 50% incidence of breast cancer compared to those with lower solar exposure [ 44 ].…”

Section: Vitamin D and Cancermentioning

confidence: 99%

“…Meta-analyses show significant inverse correlations between serum 25(OH)D concentration and incidence of bladder, breast, colorectal, kidney, and lung cancer [ 43 ]. Two studies were reported for colon and rectal cancer.…”

Section: Vitamin D and Cancermentioning

confidence: 99%

“…According to these data, black Americans would have 60% higher cancer mortality rates than white Americans. In the literature, disparities are evident for 13 cancers: bladder, breast, colon, endometrial, lung, ovarian, pancreatic, prostate, rectal, testicular, and vaginal cancer; Hodgkin’s lymphoma; and melanoma [ 43 ]. Cancer-specific mortality rates are about 25% higher for black Americans compared to white Americans.…”

Section: Vitamin D and Cancermentioning

confidence: 99%

See 2 more Smart Citations

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

et al. 2020

View full text Add to dashboard Cite

Background: Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is higher in Europe and the United States, where calcium is frequently included in the human diet; while the occurrence of these fractures is lower in developing countries, where diets are often poor in calcium. This condition is named the “calcium paradox”, and may be partially explained by phosphate toxicity, which can negatively affect mineral metabolism. It is important to maintain correct dietary calcium-phosphate balance in order to have a healthy life, reducing the risk of osteoporotic fractures in older people. Vitamin D can also act as a hormone; vitamin D2 (ergocalciferol) is derived from the UV-B radiation of ergosterol, the natural vitamin D precursor detected in plants, fungi, and invertebrates. Vitamin D3 (cholecalciferol) is synthesized by sunlight exposure from 7-dehydrocholesterol, a precursor of cholesterol that can also act as provitamin D3. Dietary intake of vitamin D3 is essential when the skin is exposed for short periods to ultraviolet B light (UV-B), a category of invisible light rays such as UV-A and UV-C. This can be considered the usual situation in northern latitudes during the winter season, or the typical lifestyle for older people and/or for people with very white delicate skin. The actual recommended daily intake of dietary vitamin D is strictly correlated with age, ranging from 5 μg for infants, children, teenagers, and adults—including pregnant and lactating women—to 15 μg for people over 65 years.

show abstract

Section: Vitamin D and Cancermentioning

confidence: 99%

Section: Vitamin D and Cancermentioning

confidence: 99%

Section: Vitamin D and Cancermentioning

confidence: 99%

See 1 more Smart Citation

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In recent years, newer and more extensive studies describing the pleiotropic effects of vitamin D and the importance of its deficiency in many diseases, not strictly related to changes occurring in the skeletal system, have been published. These research issues concern cancer diseases [ 3 , 4 , 5 ], cardiovascular disease [ 6 ], diabetes [ 7 ], as well as mental illnesses [ 8 , 9 , 10 ]. The main sources of vitamin D are both oral intake and synthesis in the skin.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Functioning of Geriatric Patients: Is Hypovitaminosis D the Next Marker of Cognitive Dysfunction and Dementia?

2018

View full text Add to dashboard Cite

The study objective is to investigate whether vitamin D is associated with the cognitive function of geriatric patients. This cross-sectional study involved 357 patients hospitalized in the geriatric ward who complained of memory problems (mean age: 82.3 years). The level of cognitive function was measured with the Mini-Mental State Examination (MMSE) and the clinical diagnosis of dementia was established according to the International Classification of Diseases (ICD-10) criteria. The serum 25-hydroxy vitamin D was measured with liquid chromatography-tandem mass spectrometry. The iterative Bayesian model averaging (BMA) procedure was applied to linear and logistic regression models in order to identify the best set of factors describing cognitive dysfunction and dementia, respectively. According to BMA, there is strong evidence that higher vitamin D levels, higher body mass index (BMI), and higher mobility function measured with the Timed Up and Go (TUG) test are independently associated with better cognitive performance and lower risk of dementia. Additionally, there is strong evidence that fewer years of education and lower vitamin B12 plasma levels independently describe worse cognitive performance. However, vitamin B12 levels higher than 800 pg/mL is negatively associated with the MMSE performance. Hypovitaminosis D in geriatric patients is an underrated marker of cognitive dysfunction and dementia.

show abstract

“…Vitamin D is believed to reduce the risk of chronic illnesses and neoplasms [ 37 , 61 ]. According to the review by Grant, the available scientific evidence supports the notion of vitamin D supplementation as a cancer prevention method [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

Ciebiera

Włodarczyk

Ciebiera

et al. 2018

IJMS

View full text Add to dashboard Cite

This article provides a detailed review of current knowledge on the role of vitamin D and its receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for future steps in this area. A literature search was conducted in PubMed using the following key words: “uterine fibroid” and “vitamin D”. The results of the available studies, published in English from January 2002 up to April 2018, have been discussed. Vitamin D is a group of steroid compounds with a powerful impact on many parts of the human body. This vitamin is believed to regulate cell proliferation and differentiation, inhibit angiogenesis, and stimulate apoptosis. Nowadays, hypovitaminosis D is believed to be a major risk factor in the development of UFs. In many studies vitamin D appears to be a powerful factor against UFs, resulting in inhibition of tumor cell division and a significant reduction in its size, however, the exact role of this compound and its receptor in the pathophysiology of UFs is not fully understood. According to available studies, vitamin D and its analogs seem to be promising, effective, and low-cost compounds in the management of UFs and their clinical symptoms, and the anti-tumor activities of vitamin D play an important role in UF biology. The synergy between vitamin D and selected anti-UF drugs is a very interesting issue which requires further research. Further studies about the biological effect of vitamin D on UF biology are essential. Vitamin D preparations (alone or as a co-drugs) could become new tools in the fight with UFs, with the additional beneficial pleiotropic effect.

show abstract

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Cited by 28 publications

References 73 publications

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

Cognitive Functioning of Geriatric Patients: Is Hypovitaminosis D the Next Marker of Cognitive Dysfunction and Dementia?

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

Contact Info

Product

Resources

About