The 20th century saw the development of a highly efficient nutrient industry producing affordable fertilizers that contributed greatly to increased food, feed, fiber, and fuel production for a growing global population. Plant nutrient production and use in the 21st century faces pressure to improve efficiency and outcomes. The nutrient industry has historically operated with large volumes and low margins, and has, at times, been slow to embrace innovations. However, the landscape has changed, driven by the demand for superior products, practices, and environmental stewardship. This transition marks the advent of what experts term “responsible plant nutrition” (International Fertilizer Association, 2024). This is the third and final article in a series on the past, present, and future of the North American fertilizer industry. Earn 1.5 CEUs in Nutrient Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.