A review of the herbal phosphodiesterase inhibitors; Future perspective of new drugs

Rahimi, Roja; Ghiasi, Sima; Azimi, Hanieh; Fakhari, Sima; Abdollahi, Mohammad

doi:10.1016/j.cyto.2009.11.005

Cited by 114 publications

(94 citation statements)

References 103 publications

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“…They play an important role in protection of plants from microbial and insect attack. Many studies reported that flavonoids exhibit various effects as antioxidant (Siahpoosh et al, 2016;Balci & Özdemir, 2016), anti-cancer (Androutsopoulos et al, 2010;Ma et al, 2015), anti-allergic (Park et al, 2006), anti-thrombotic and vasodilatory (Rahimi et al, 2010), anticholinesterase (Ertas et al, 2016) actions. Finally, because of their UV-absorbing properties, flavonoids protect plants from the UV radiation of the sun and scavenge UV-generated reactive oxygen species (Shirley, 1996).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

et al. 2018

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On this study, heated reflux extraction method has been used to identify the phenolic compounds from C. humilis var. argentea leaflets, rachis and fruits. Extractions were performed in both ultrapure water and 80% methanol solvents. The efficiency of procedures was determined in terms of the quality and quantity of phenolic acids and flavonoids identified. Chamaerops extracts have been characterized by high concentrations of phenolic compounds, which play a crucial role in protection against various diseases. LC-MS/MS was used to determine the chemical profile of various extracts obtained from Chamaerops. The results showed that the major components in leaflets and fruits extracts were quinic, malic and chlorogenic acids. On addition, nine minor acidic components were identified. Dn the other hand, rutin and hesperidin were found to be the major flavonoids. The methanol extract was shown as being the most efficient to identify phenolic compounds in C. humilis. Keywords: Chamaerops humilis L.; LC-ESO-MS/MS; phenolic compounds; chemical composition; extracts.Practical Application: Chamaerops humilis L. rich in flavonoids and phenolic acids was a great promising source of different bioactive components.

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Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

et al. 2018

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“…Some natural products act like non-selective PDE inhibitors as the methylxanthines caffeine and theophylline, but others show similar effects to PDE-5 inhibitors, for example: flavonoids and derivatives (quercetin from Allium cepa, pyrano-isoflavones from Eriosema kraussianum -Kraussianone 1 and 2); alkaloids (Neferin from Nelumbo nucifera, Berberine from Berberis aristata, Papaverine from Papaver somniferum -used in association with Prostaglandin-E1 to injections intracavernosal), saponins (Steroidal saponins from Allium tuberosum), coumarins (Osthole from Angelica pubescens) and terpenes (Forskolin from Coleus forskohlii) (Drewes et al, 2003;Guohua et al, 2009;Rahimi et al, 2009;Sumalatha et al, 2010;Zanolari, 2003). The success of PDE-5 inhibitors, particularly of Viagra, the first inhibitor that has been marketed, the aging of the population and the quest for improved quality of life led to the search for new drugs with fewer side effects.…”

Section: Male Dysfunction Therapiesmentioning

confidence: 99%

Phytochemistry of some Brazilian Plants with Aphrodisiac Activity

Silva¹,

Borges²,

Velozo³

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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“…Inhibitors of PDEs are being used in many pharmacological applications for their vasodilatory, cardiotonic, antidepressant, smooth muscle relaxant, anti-inflammatory, and bronchodilator effects. Many plant metabolites have been shown to be active PDE inhibitors (Rahimia et al, 2010). Mammalian α-carbonic anhydrases have important physiological functions in respiratory homeostasis, pH balance, regulation of intracellular osmotic pressure, and gluconeogenesis.…”

Section: Enzyme Inhibitionmentioning

confidence: 99%

Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.

Wahab

Jan

Rehman

et al. 2018

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Scandix pecten-veneris L. is a less studied wild edible herb and is considered an extinct plant species in many parts of the world. This study was designed to evaluate its phytochemical composition and biological potential of S. pecten-veneris L. Methods: Phytochemicals including alkaloids, flavonoids, polyphenols, and tannins were determined in extracts of S. pecten-veneris. Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), while reducing power was tested by ferric reducing/antioxidant power (FRAP) assay. Antimicrobial activity against seven bacterial and four fungal strains was evaluated using agar well diffusion assay. Enzymes inhibition study was performed for urease, phosphodiesterase-I, and catalase-II. Results: S. pecten-veneris showed moderate antiradical activity and reducing potential of hydroxyl radicals to about 20% of the initial value. The antioxidant activity of various extracts of S. pecten-veneris showed a linear correlation with total phenolic contents in the order of water>n-butanol>chloroform>ethyl acetate>methanol extracts. S. pecten-veneris leaves showed the highest inhibitory activity against Staphylococcus aureus while the highest antifungal activity was observed against Candida albicans. The plant extract was most potent against urease enzymes but showed moderate activity against phosphodiestrase-I and carbonic anhydrase-II. Conclusions: Our data demonstrate that in addition to its culinary uses, S. pecten-veneris has good medicinal potential and hence could be used for treating some specific health ailments.

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A review of the herbal phosphodiesterase inhibitors; Future perspective of new drugs

Cited by 114 publications

References 103 publications

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

Phytochemistry of some Brazilian Plants with Aphrodisiac Activity

Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.

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