A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng, Ruitang

doi:10.2174/1876142911204010050

Cited by 33 publications

(17 citation statements)

References 41 publications

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“…This agrees with the results of previous studies that have shown that other food-based antioxidants can improve glycemic control in healthy subjects as in those with T2DM [13,14,16,18]. Research suggests that antioxidants may reduce blood glucose levels by affecting carbohydrate digestion in the small intestine due to inhibition of α-glucosidase in gut mucosa [19,23] or inhibition of -amylase, a key enzyme for breaking down starch [23].…”

Section: Discussionsupporting

confidence: 91%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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Background: Obesity and diabetes are highly prevalent in Western countries. Both of these conditions can be associated with impaired glucose control and hyperglycemia. Studies have identified that antioxidants have the ability to regulate blood glucose levels. However, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. Thus, this study aimed to measure the effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals. Methods:Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed five different high-antioxidant food extracts (one per session, each >48 hours apart) that were matched for total antioxidant content 10 mins prior to ingestion of 50 g of available carbohydrate from either a glucose load or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours and the incremental area under the glucose curve (IAUC) was also measured. The IAUC values for the test foods were compared to the glucose-only and bread-only controls.Results: Amla berry-, grape seed-rooibos tea-and green tea-extracts as well as propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25-40% compared to the glucose-only or white bread controls (all p < 0.05). Conclusion:Antioxidants are able to modulate postprandial glucose responses in healthy subjects. These results suggest that further research is warranted to determine whether these antioxidant-rich foods are beneficial to people with prediabetes or type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 91%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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“…Many medicinal plants are known to have an effect on glucose metabolism [27]. In this study, methanolic leaf extract C. volkensii did not cause either hypoglycemia or hyperglycemia.…”

Section: Steroids -mentioning

confidence: 44%

Acute and Sub-Chronic Oral Toxicity Study of Methanolic Extract of Caesalpinia volkensii (Harms)

Musila¹,

Ngai²,

Mbiri³

et al. 2017

J Drug Metab Toxicol

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Medicinal plant Caesalpinia volkensii is used to treat Malaria, conjunctivitis, retinoblastoma, and eyelid swelling as well as gonorrhoea and bilharzia. Animal toxicity information on this plant is limited. This medicinal plant was collected in Embu County in Kenya to evaluate its Acute and sub-chronic toxicity using Wistar rats. The rats were orally administered with different doses of the plants extracts. They were weighed on first day and after every 7 days during treatment with the extract. Signs of toxicity were also observed. After 28 days, the rats were sacrificed and blood samples taken for full hemogram, renal and liver function tests. Weight of internal organs was also recorded. Data was analysed using Minitab statistical software version 17. In acute toxicity studies, C. volkensii extracts did not result to death at extract dose of 2000 mg/kg body weight. In sub-chronic toxicity studies, there was no significance difference in body weight and organ weight among the groups treated with the plant extract (p>0.05). Treatment with extract dose of 1000 mg/kg body weight resulted in significant increase in total bilirubin and aspartate aminotransferase (P˂0.05). In addition, 100 mg/kg body weight resulted in significant decrease in haemoglobin and haematocrit. Qualitative phytochemical screening confirmed the presence of various phytochemicals which have the ability to protect erythrocytes from oxidative damage as well as erythropoietin stimulatory activities. It was therefore concluded that methanolic leaf extract of C. volkensii is safe for acute oral administration. However, care should be exercised in sub-chronic exposure at 1000 mg/kg body weight and above to avoid liver injury.

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“…Patients with prediabetes and diabetes have significantly increased risk for cardiovascular diseases and other complications. Currently, management of hyperglycemia includes pharmacological interventions, physical exercise, and change of lifestyle and diet (Deng, 2012). The use of orthodox drugs in the management of diabetes mellitus has not improved the situation.…”

Section: Introductionmentioning

confidence: 99%

“…Since the existing drugs for the treatment of diabetes mellitus do not satisfy our need completely, the search for new drugs continues. Food stuffs and supplements have increasingly become attractive alternatives to prevent or treat hyperglycemia, especially in subjects with mild hyperglycemia (Bhutkar, Bhise, 2011;Deng, 2012). Therefore, there has been increasing demand for the use of plant products and food stuffs with antidiabetic activity due to low cost, easy availability and lesser side effects.…”

Section: Introductionmentioning

confidence: 99%

In vitro hypoglycemic effects of unripe and ripe fruits of Musa sapientum

Bhinge¹,

Bhutkar²,

Randive³

et al. 2018

Braz. J. Pharm. Sci.

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The present study was undertaken to verify the hypoglycemic potential of unripe and ripe fruit extracts of Musa sapientum by using various in-vitro techniques, namely glucose adsorption capacity, glucose diffusion, amylolysis kinetics and glucose transport across the yeast cells. The results revealed that the unripe and ripe fruit extracts of Musa sapientum adsorbed glucose and the adsorption of glucose increased remarkably with an increase in glucose concentration. There were no significant (p≤0.05) differences between their adsorption capacities. In the amylolysis kinetic experimental model the rate of glucose diffusion was found to be increased with time from 30 to 180 min and both extracts exhibited significant inhibitory effects on the movement of glucose into external solution across the dialysis membrane as compared to control. The plant extracts also promoted glucose uptake by the yeast cells and enhancement of glucose uptake was dependent on both the sample and glucose concentration. The hypoglycemic effect exhibited by the extracts was observed to be mediated by inhibiting α-amylase, inhibiting glucose diffusion by adsorbing glucose and by increasing glucose transport across the cell membranes as revealed by an in-vitro model of yeast cells.

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A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Cited by 33 publications

References 41 publications

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Acute and Sub-Chronic Oral Toxicity Study of Methanolic Extract of Caesalpinia volkensii (Harms)

In vitro hypoglycemic effects of unripe and ripe fruits of Musa sapientum

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