A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng, Ruitang

doi:10.2174/2212798411204010050

Cited by 28 publications

(24 citation statements)

References 52 publications

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“…For centuries, cinnamon has been a popular spice used by different cultures around the world (Ranasinghe et al, 2013), and it is among the best-selling herbal dietary supplements as recently reported (Andrew & Izzo, 2017). Cinnamon is an herbal remedy used traditionally by patients with PCOS to improve their menstrual cycle (Bandara, Uluwaduge, & Jansz, 2012;Deng, 2012). In traditional Persian medicine (Hashempur, Khademi, Rahmanifard, & Zarshenas, 2017) It is obtained from the inner bark of the cinnamomum tree (Deng, 2012;Wickenberg, Lindstedt, Berntorp, Nilsson, & Hlebowicz, 2012).…”

mentioning

confidence: 99%

“…Cinnamon is an herbal remedy used traditionally by patients with PCOS to improve their menstrual cycle (Bandara, Uluwaduge, & Jansz, 2012;Deng, 2012). In traditional Persian medicine (Hashempur, Khademi, Rahmanifard, & Zarshenas, 2017) It is obtained from the inner bark of the cinnamomum tree (Deng, 2012;Wickenberg, Lindstedt, Berntorp, Nilsson, & Hlebowicz, 2012).…”

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confidence: 99%

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Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial

Hajimonfarednejad

Nimrouzi

Heydari

et al. 2017

Phytotherapy Research

108

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Our aim is to assess the effect of cinnamon powder capsules on insulin resistance, anthropometric measurements, glucose and lipid profiles, and androgens of women with polycystic ovarian syndrome (PCOS). Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double-blind placebo-controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10 mg/day for the last 10 days of their menstrual cycles. The cases were randomly allocated to 2 groups. The women in the first group were treated by cinnamon powder capsules 1.5 g/day in 3 divided doses for 12 weeks and the second group by similar placebo capsules. Anthropometric measurements, fasting blood sugar, fasting insulin, blood glucose 2 hr after taking 75 g oral glucose, HbA1c, testosterone, dehydroepiandrosterone sulphate, homeostatic model assessment for insulin resistance, triglyceride, and cholesterol (low-density lipoprotein, high-density lipoprotein, and total) before and after the intervention were evaluated and compared as outcome measures. Fasting insulin (p = .024) and homeostatic model assessment for insulin resistance (p = .014) were reduced after 12 weeks in the cinnamon group compared with the placebo. There was also a significant decrease in low-density lipoprotein in cinnamon group (p = .004) as compared with baseline that caused significant difference with placebo (p = .049). However, changes in other outcome measurements did not lead to statistically significant difference with placebo. The present results suggest that complementary supplementation of cinnamon significantly reduced fasting insulin and insulin resistance in women with PCOS.

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confidence: 99%

mentioning

confidence: 99%

Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial

Hajimonfarednejad

Nimrouzi

Heydari

et al. 2017

Phytotherapy Research

108

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“…In addition, it was evidenced that fenugreek (extracts) stimulates insulin secretion and/or activity and its receptor expression, and thereby improves diabetes mellitus wound healing. 10,12,21 In our experimental series, granulocytes and total white blood cell counts were augmented. This event might explain Patil et al, 18 reported allergic reaction following fenugreek usage, in some clinical cases.…”

Section: Discussionmentioning

confidence: 80%

“…[4][5][6][7][8] Other T. foenum-graecumfractions modulate blood sugar levels and insulin secretion and thereby ameliorate the woundhealing and prevent diabetes. [9][10][11][12] The anti-obesity effect of fenugreek might be bypassed through repressing adipocytes' proliferation and lipids metabolism. 13,14 It also stimulates anti-oxidative enzymes activities and decreases the ROS release, a major protective pathway against several pathologies.…”

Section: Introductionmentioning

confidence: 99%

Some biological effects of Trigonella foenum- graecom L, in healthy men

Ben-Nasr¹,

Bouzidi²,

Gharbi³

et al. 2018

EMIJ

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Fenugreek (Trigonella foenumm-graecum L.) is widely used against several diseases. It owned great interest because it contains numerous biologically active substances. In this work, the in vivo effect of fenugreek seeds' intake on hemodynamic, blood sugar level and hematological parameters was evaluated in healthy volunteers. Ten healthy volunteer men were included in the experiment. Their overnight fasting blood sugar level, hemodynamic and hematological parameters were measured before, and one hour after the intake of 10 g of powdered fenugreek seeds in a water suspension. The T-paired test showed significant decrease in the arterial blood pressure (from 9,2 ± 0,65 to 8,43 ± 0,31cmHg for the mean arterial pressure; and 7,8 ± 1,03 to 6,7 ± 0,67cmHgfor the arterial diastolic pressure) and heart frequency (from 77,3 ± 3,23 to 75,40 ± 3,37 bits/min), and an increase in total white blood cell (8,24 ± 2,29and 9,16± 2,20.10 3 /µL; p ≤0,01) and granulocytes (5,26± 1,94 to 5,70 ± 1,86 .10 3 /µL, p ≤0,01) counts, one hour after fenugreek seeds intake. In addition the overnight-fasting blood sugar level was diminished from 5,71 ± 0,37 to 5,37± 0,44 mmol/L, at p ≤ 0,001.The present work demonstrates the potential anti-hypertensive and anti-hyperglycemic effects of fenugreek seeds, and may support its use as alternate remedy against these chronic pathologies but cautions its application before conducting specific allergic tests .

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“…support the ability of these combined agents to effectively lower blood glucose levels. Nevertheless, the usage of these herbal food supplements should not be discounted by healthcare professionals now that they are becoming increasingly popular, especially for those whose blood glucose levels are on the borderline and pharmacological therapies have not been initiated (Deng 2012).…”

mentioning

confidence: 99%

Acute Modulatory Effects of Apple Cider Vinegar, Garlic, Ginger, Lemon and Honey Mixture, with and Without Exercise on Postprandial Glycemia in Non-Diabetic Females

Ishak

George

Ibrahim

et al. 2018

JSKM

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Postprandial hyperglycemia is independently related to cardiovascular disease. Garlic, ginger, lemon, honey and apple cider vinegar are known to have anti-glycemic properties. However, the effectiveness of combination of these natural products on reducing postprandial glycemia is uncertain. The aim of the present study was to investigate the glucoselowering effect of a novel mixture consisting of apple cider vinegar, garlic, ginger, lemon, and honey; alone and in combination with exercise in response to a high-carbohydrate meal in non-diabetic individuals. Ten, female subjects (mean age: 25 ± 2.67 years, mean BMI: 22.6 ± 3.5 kg/m 2) participated in this randomised, cross-over intervention consisting of four trials: control (CON), mixture only (MIX), exercise only (EX), and exercise + mixture (EX-MIX). All trials involved consumption of a high-carbohydrate breakfast, then followed by rest in CON, consumption of natural product mixture in MIX, brisk-walking exercise in EX, and combination of mixture and exercise in EX-MIX. Blood glucose was measured at fasting, and at 30, 60, 90, 120 minutes post meal. Postprandial glucose response was calculated as area under the glucose curve. Two-way repeated measures ANOVA showed a significant group and time interaction (p < 0.001). Compared to CON, postprandial glucose responses were 8%, 13% and 15% lower in MIX (p = 0.049), EX (p = 0.001) and EX-MIX (p = 0.005) respectively. Postprandial glucose was 8% lower in EX-MIX compared to MIX (p = 0.002). In conclusion, consuming natural product mixture containing garlic, ginger, lemon, honey and apple cider vinegar reduced postprandial glycemia to a certain extent, however, combining mixture with exercise produced a greater attenuation effect compared to consuming mixture alone. This finding is indicative of a potential benefit of the novel mixture as a complementary management of hyperglycemia in high-risk individuals.

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A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Cited by 28 publications

References 52 publications

Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial

Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial

Some biological effects of Trigonella foenum- graecom L, in healthy men

Acute Modulatory Effects of Apple Cider Vinegar, Garlic, Ginger, Lemon and Honey Mixture, with and Without Exercise on Postprandial Glycemia in Non-Diabetic Females

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