A review of the literature on the impact of renal cancer therapy on quality of life

Bird, Joanne; Hayter, Mark

doi:10.1111/j.1365-2702.2009.02875.x

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Compared to other malignant tumors, the incidence rate and mortality rate of bladder/kidney cancer was relatively low [ 2 ], and bladder (67.3%) and kidney cancer (62.0%) had high level of age-standardized 5-year relative survival [ 3 ]. Consequently, there has been an increasing interest with regards to the evaluation of quality of life in bladder/kidney cancer patients [ 4 – 6 ], such as long-term survivors, but not much is generally known regarding the mental health issues of newly diagnosed patients.…”

Section: Introductionmentioning

confidence: 99%

Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

Liu

Shi

et al. 2016

PLoS ONE

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PurposePsychological disorders have been proven to be associated with poor physiological, psychological and immune outcomes in cancer patients. However, despite of many challenges of the changed self-image/body image and the altered sexual/urinary function, relatively little is known about psychological disorders of patients with newly diagnosed bladder and kidney cancer. We aimed to investigate the prevalence of depression, anxiety, post-traumatic stress disorder (PTSD) and the associated psychosocial factors among bladder/kidney cancer patients.MethodsA cross-sectional study was conducted of consecutive inpatients with bladder/kidney cancer in the First Affiliated Hospital of China Medical University in Liaoning Province, northeast China. A total of 489 early-stage cancer patients eligible for this study completed questionnaires on demographic and clinical variables, depression, anxiety, PTSD, perceived social support and positive psychological variables (hope, optimism and resilience) anonymously during October 2013 and August 2014. Hierarchical regression analysis was used to examine the relationships between psychosocial resources and psychological disorders, while controlling for possible covariates.ResultsThe prevalence of depression, anxiety and PTSD was 77.5%, 69.3% and 25.2%, respectively, while 24.9% of patients had psychological co-morbidity. Psychosocial resources together explained more than one-third of the variance on psychological disorders. Under standardized estimate (β) sequence, patient’s perception of social support from family was significantly associated with depression, anxiety and PTSD (p < 0.01). Optimism and resilience showed integrated and independent effects on psychological disorders, and hope represented the significant association with PTSD only (p < 0.01).ConclusionsThe high prevalence of psychological disorders in newly diagnosed patients with early-stage bladder/kidney cancer should receive more attention in Chinese medical settings. Additionally, in consideration of the different protective effects of psychosocial resources, the present study demonstrated that one complete psychological intervention integrating the associated psychosocial factors are necessary to ameliorate psychological disorders so as to provide patients with a more holistic cancer care.

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Section: Introductionmentioning

confidence: 99%

Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

Liu

Shi

et al. 2016

PLoS ONE

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“…Although several therapeutic approaches have been applied to the treatment of RCC, including surgery, immunological therapies and vaccine treatment (1), further improvements are needed. Notably, the modulation of the apoptotic response provides new prospects for therapeutic strategies in cancer (2,3).…”

Section: Introductionmentioning

confidence: 99%

Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells

Wei

Zhou²,

Hu³

et al. 2012

Oncology Letters

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Abstract. Tanshinone IIA (Tan IIA), isolated from the Chinese medicinal herb Danshen, has been reported to have anticancer effects in several tumor models, while its effects on renal cell carcinoma have not been studied. In the present study, we evaluated the effects of Tan IIA on growth inhibition and apoptosis in the renal cancer cell line 786-O and its mechanism of action. Results of the MTT assay indicated that the treatment of 786-O cells with Tan IIA resulted in a concentration-dependent decrease in cell viability. Flow cytometry analysis revealed that Tan IIA treatment caused apoptosis following cell cycle perturbation. Furthermore, we examined the expression of cell cycle and apoptosis-related proteins using immunoblotting, which indicated an upregulation of p53, p21, bax and caspase-3 in Tan IIA-treated cells compared with Tan IIA-untreated cells. These results suggest that the activation of p53 and the upregulation of its target genes, including p21 and bax, may be involved in the mitochondrial apoptosis induced by Tan IIA in 786-O cells.

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“…Only a few studies have addressed the question of QOL in renal cancer. 69 An interesting approach was proposed under the auspices of the Kidney Cancer Association (KCA). 70 The authors studied a composite QOL index involving demographics, medical history,…”

Section: Quality Of Life In Elderly Patients With Kidney Cancersmentioning

confidence: 99%

Quality of Life in Elderly Patients with Urological Malignancies — A Review of Standard Questionnaires

Terret¹,

Droz²

2011

European Oncology &Amp; Haematology

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Quality of life (QOL) is a very complex subject and is difficult to measure in elderly patients. Only a few tools have been validated in this population: the Medical Outcome Study Short Form 36 (SF-36) and the European Organisation for Research and Treatment of Cancer (EORTC) questionnaire QLQ-C30 with addition of the QLQ-ELD15 module. Other tools have been studied in genito-urinary tumours: the Functional Assessment of Cancer Therapy (FACT)General (FACT-G) and specific tools adapted for use in patients with kidney and bladder cancers. Moreover, different tools must be used in different clinical settings, such as localised or castration-refractory prostate cancers. Thus, there is an unmet need for both standardisation and co-ordination of QOL evaluation tools in genito-urinary cancers. The availability of good QOL tools would enable an increase in the efficiency of decision-making in these cancers where comparisons between the side effects of the different treatments are difficult.

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A review of the literature on the impact of renal cancer therapy on quality of life

Cited by 6 publications

References 34 publications

Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells

Quality of Life in Elderly Patients with Urological Malignancies — A Review of Standard Questionnaires

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