A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair

Johnson, Amy J. Wagoner; Herschler, Brad A.

doi:10.1016/j.actbio.2010.07.012

Cited by 551 publications

(370 citation statements)

References 126 publications

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“…203,211 The formation of these materials is activated by mixing various calcium phosphate phases with a liquid phase at a specific pH. The pH of the chemical reaction dictates the type of final product; HA forms at pH .4.2 or brushite at pH ,4.2.…”

Section: Bone Cements/composites With Remineralizing Actionmentioning

confidence: 99%

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Demineralization–remineralization dynamics in teeth and bone

Neel¹,

Aljabo²,

Strange³

et al. 2016

IJN

522

232

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Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization–remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.

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Section: Bone Cements/composites With Remineralizing Actionmentioning

confidence: 99%

“…203 The main shortcomings of these materials, however, are the mechanical properties. These properties were improved through formation of polymer composites containing calcium phosphate.…”

Section: Bone Cements/composites With Remineralizing Actionmentioning

confidence: 99%

Demineralization–remineralization dynamics in teeth and bone

Neel¹,

Aljabo²,

Strange³

et al. 2016

IJN

522

232

View full text Add to dashboard Cite

show abstract

“…24 However, their application as implants is restricted by their brittleness and difficulty in molding. 25 Adding calcium phosphate into a polymer matrix for preparation of calcium phosphate/ polymer composites is a common approach to solving these problems. 26 It is reported that these kinds of biodegradable composite materials have improved mechanical properties and bioactivity, and are able to induce cells to attach or proliferate upon them.…”

Section: Fan Et Almentioning

confidence: 99%

Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

Fan¹,

Deng²,

Zhou³

et al. 2014

IJN

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In this study, L-lactide was used to modify the tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) surface which can form functionalized poly(l-lactic acid) (PLLA)-grafted β-TCP (g-β-TCP) and PLLA-grafted TTCP (g-TTCP) particles. The g-β-TCP and g-TTCP obtained were incorporated into a PEG-PCL-PEG (PECE) matrix to prepare injectable thermosensitive hydrogel composites. The morphology of the hydrogel composites showed that the g-β-TCP and g-TTCP particles dispersed homogeneously into the polymer matrix, and each hydrogel composite had a three-dimensional network structure. Rheologic analysis showed that the composite had good thermosensitivity. Changes in calcium concentration and pH in simulated body fluid solutions confirmed the feasibility of surface-functionalized calcium phosphate for controlled release of calcium. All the results indicate that g-β-TCP/PECE and g-TTCP/PECE hydrogels might be a promising protocol for tissue engineering.

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“…Hybridization of HAp with organic molecules is a promising approach to develop functional HAp nanomaterials. There are several reports describing the preparation of hybrid HAp nanomaterials using surfactants [7], block copolymers [8] and liposomes [9] as organic components. Block copolymers with calcium phosphate nanoparticles showed enhanced cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

et al. 2012

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Nanosized hydroxyapatite (HAp) materials have received much attention in the context of their advanced biomedical applications, including tissue engineering and drug delivery systems. Hybridization of nanosized HAp with organic molecules is a promising approach to facilitate the preparation of HAp nanomaterials. Here, templated mineralization using self-assembled nanogels modified with tricarboxylate groups was performed to yield the hybrid HAp nanomaterial. In the pH gradient method, the nanogel acted as an excellent template for the formation of well-dispersed HAp particles. Transmission electron microscopy, selected area electron diffraction patterns and energy-dispersive X-ray spectroscopy of these particles revealed that amorphous nanoparticles of amorphous calcium phosphate formed first, followed by transformation to crystalline hydroxyapatite. OPEN ACCESSPolymers 2012, 4 1057

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A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair

Cited by 551 publications

References 126 publications

Demineralization–remineralization dynamics in teeth and bone

Demineralization–remineralization dynamics in teeth and bone

Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

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A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair

Cited by 551 publications

References 126 publications

Demineralization&ndash;remineralization dynamics in teeth and bone

Demineralization&ndash;remineralization dynamics in teeth and bone

Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

Contact Info

Product

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Demineralization–remineralization dynamics in teeth and bone

Demineralization–remineralization dynamics in teeth and bone